2019
DOI: 10.1007/s11356-019-05383-9
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Ovariectomy predisposes female rats to fine particulate matter exposure’s effects by altering metabolic, oxidative, pro-inflammatory, and heat-shock protein levels

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Cited by 17 publications
(6 citation statements)
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“…Extensive studies have been conducted on the role of estrogen in various metabolisms, immunity, and inflammatory processes in rodents and humans [78]. Thanks to more sensitive and accurate proteomic techniques, a number of proteins and pathways in visceral fat were found in OVX rodent models [79].…”
Section: Alterations In Fatty Acid Metabolismmentioning
confidence: 99%
“…Extensive studies have been conducted on the role of estrogen in various metabolisms, immunity, and inflammatory processes in rodents and humans [78]. Thanks to more sensitive and accurate proteomic techniques, a number of proteins and pathways in visceral fat were found in OVX rodent models [79].…”
Section: Alterations In Fatty Acid Metabolismmentioning
confidence: 99%
“…The cessation of ovarian hormones production in menopause is often followed by increased body weight gain and adiposity, associated with obesity-related co-morbidities (11,28). In both humans and rodents, a role of estrogens in metabolic, immune, and inflammatory processes has been established, although the complexity by which these effects occur is not fully understood (20,45). The lack of estrogens after menopause has been associated with a shift of fat distribution from subcutaneous to visceral, with impairment of the sensitivity to insulin and leptin, predisposition to diabetes and to anxiety and depressive disorders (5,14,23).…”
Section: Introductionmentioning
confidence: 99%
“…Estrogen reduction promoted by ovariectomy results in greater weight gain and adiposity, changes in the lipid profile [ 57 ], and uterine atrophy [ 58 ]. The administration of 17β-estradiol benzoate (EB) to ovariectomized (ovx) animals was associated with a reduction in the amount of ingested food and less body weight gain [ 59 ].…”
Section: Discussionmentioning
confidence: 99%