Overexpression of Hdac6 extends reproductive lifespan in mice

Zhang, Xiaoxi; Yang, Jiao; Wang, Haiying; Guo, Renpeng; Yin, Yu; Zhang, Dongdong; Zhang, Qian; Wang, Hua; Zhou, Zhongli; Chen, Lingyi; Zhou, Jun; Liu, Lin

doi:10.1007/s13238-017-0375-9

Cited by 14 publications

(14 citation statements)

References 15 publications

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“…Indeed, the reduced expression of HDAC6 contributes to a decline in stem cell numbers 43 and brain function 44 during ageing. Furthermore, HDAC6 overexpression in transgenic mice increases the reproductive lifespan of animals 45 .…”

Section: Resultsmentioning

confidence: 99%

Prediction and characterization of human ageing-related proteins by using machine learning

Kerepesi

Daróczy

Sturm

et al. 2018

Sci Rep

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Ageing has a huge impact on human health and economy, but its molecular basis – regulation and mechanism – is still poorly understood. By today, more than three hundred genes (almost all of them function as protein-coding genes) have been related to human ageing. Although individual ageing-related genes or some small subsets of these genes have been intensively studied, their analysis as a whole has been highly limited. To fill this gap, for each human protein we extracted 21000 protein features from various databases, and using these data as an input to state-of-the-art machine learning methods, we classified human proteins as ageing-related or non-ageing-related. We found a simple classification model based on only 36 protein features, such as the “number of ageing-related interaction partners”, “response to oxidative stress”, “damaged DNA binding”, “rhythmic process” and “extracellular region”. Predicted values of the model quantify the relevance of a given protein in the regulation or mechanisms of the human ageing process. Furthermore, we identified new candidate proteins having strong computational evidence of their important role in ageing. Some of them, like Cytochrome b-245 light chain (CY24A) and Endoribonuclease ZC3H12A (ZC12A) have no previous ageing-associated annotations.

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Section: Resultsmentioning

confidence: 99%

Prediction and characterization of human ageing-related proteins by using machine learning

Kerepesi

Daróczy

Sturm

et al. 2018

Sci Rep

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“…HDAC6 is involved in both α-tubulin acetylation and ubiquitination (Seigneurin-Berny et al, 2001). The HDAC6 activity is associated with sperm motility in rats and its overexpression has been associated with an extension of reproductive lifespan in mice (Parab et al, 2015;Zhang et al, 2017). TSC22D3 encodes a member of TSC22-domain leucine zipper family, which is widely associated with male fertility due to its essential function regulating spermatogonial survival and spermatogenesis (Suarez et al, 2012;Ngo et al, 2013).…”

Section: Genes Shared Exclusively Among B Indicus or Among B Indicumentioning

confidence: 99%

Genetic mechanisms underlying spermatic and testicular traits within and among cattle breeds: systematic review and prioritization of GWAS results1

Fonseca

Santos

Lam

et al. 2018

Journal of Animal Science

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Reduced bull fertility imposes economic losses in bovine herds. Specifically, testicular and spermatic traits are important indicators of reproductive efficiency. Several genome-wide association studies (GWAS) have identified genomic regions associated with these fertility traits. The aims of this study were as follows: 1) to perform a systematic review of GWAS results for spermatic and testicular traits in cattle and 2) to identify key functional candidate genes for these traits. The identification of functional candidate genes was performed using a systems biology approach, where genes shared between traits and studies were evaluated by a guilt by association gene prioritization (GUILDify and ToppGene software) in order to identify the best functional candidates. These candidate genes were integrated and analyzed in order to identify overlapping patterns among traits and breeds. Results showed that GWAS for testicular-related traits have been developed for beef breeds only, whereas the majority of GWAS for spermatic-related traits were conducted using dairy breeds. When comparing traits measured within the same study, the highest number of

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“…Emerging and re‐emerging infectious diseases pose an increasing threat to global health . Clarifying the molecular mechanisms underlying viral infection can improve the detection, control, and treatment of viral diseases . Viruses are noncellular life forms composed of proteins and a DNA or RNA genome wrapped in a protective protein coat.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Clarifying the molecular mechanisms underlying viral infection can improve the detection, control, and treatment of viral diseases. [4][5][6][7][8] Viruses are noncellular life forms composed of proteins and a DNA or RNA genome wrapped in a protective protein coat. As parasites, viruses infect an organism and selfreplicate using host cellular components.…”

Section: Introductionmentioning

confidence: 99%

Alteration of cell junctions during viral infection

2020

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Cell junctions serve as a protective barrier for cells and provide an important channel for information transmission between cells and the surrounding environment. Viruses are parasites that invade and commandeer components of host cells in order to survive and replicate, and they have evolved various mechanisms to alter cell junctions to facilitate viral infection. In this review, we examined the current state of knowledge on the action of viruses on host cell junctions. The existing evidence suggests that targeting the molecules involved in the virus‐cell junction interaction can prevent the spread of viral diseases.

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Overexpression of Hdac6 extends reproductive lifespan in mice

Cited by 14 publications

References 15 publications

Prediction and characterization of human ageing-related proteins by using machine learning

Prediction and characterization of human ageing-related proteins by using machine learning

Genetic mechanisms underlying spermatic and testicular traits within and among cattle breeds: systematic review and prioritization of GWAS results1

Alteration of cell junctions during viral infection

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