Overexpression of miR-758 inhibited proliferation, migration, invasion, and promoted apoptosis of non-small cell lung cancer cells by negatively regulating HMGB

Zhou, Guohua; Lu, Yanxia; Xie, Jinglian; Gao, Zikun; Wu, Xiaoqing; Yao, Weitao; Gu, Weiguang

doi:10.1042/bsr20180855

Cited by 25 publications

(25 citation statements)

References 42 publications

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“…miRNAs can regulate nearly all biological processes, such as proliferation, differentiation, senescence, migration, and invasion of cancer cells including NSCLC . For example, miR‐155‐5p can inhibit the proliferation, migration, and invasion of NSCLC cells via regulating high‐mobility group box . While miR‐411 can promote lung carcinogenesis by directly targeting suppressor genes SPRY4 and TXNIP .…”

Section: Introductionmentioning

confidence: 99%

miR‐155‐5p and miR‐760 mediate radiation therapy suppressed malignancy of non‐small cell lung cancer cells

et al. 2019

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MicroRNAs (miRNAs) play important roles in tumorigenesis of various cancers. Recent study suggested that miRNAs are involved in the therapeutic functions of radiation during cancer treatment. We found that radiation can decrease the migration and invasion of non-small cell lung cancer (NSCLC) cells. Mechanistically, radiation can significantly increase the expression of miR-155-5p and miR-760 in NSCLC cells. Knockdown of miR-155-5p and miR-760 can attenuate radiation suppressed proliferation of NSCLC cells. Among the various targets of miR-155-5p, radiation can decrease the expression of HIF-1α. Similarly, radiation can also suppress the expression of IL-6 via a miR-760 dependent pathway. Gain and loss of function studies confirmed that both HIF-1α and IL-6 were involved in the radiation suppressed proliferation of NSCLC cells. Collectively, our data showed that radiation can regulate the expression of miR-155-5p and miR-760 to suppress the malignancy of NSCLC cells. © 2019 BioFactors, 45(3):393-400, 2019

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Section: Introductionmentioning

confidence: 99%

miR‐155‐5p and miR‐760 mediate radiation therapy suppressed malignancy of non‐small cell lung cancer cells

et al. 2019

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“…Besides that, we found miR-1179 inhibited NPC progression by downregulating HMGB3. Similarly, miR-758 was reported to inhibit proliferation, migration, invasion of non-small cell lung cancer cells by negatively regulating HMGB3 [23]. More importantly, lncRNA-SNHG5 was found to facilitate NPC development by upregulating HMGB3, which has not been investigated in NPC.…”

Section: Discussionmentioning

confidence: 99%

LncRNA SNHG5 promotes nasopharyngeal carcinoma progression by regulating miR-1179/HMGB3 axis

et al. 2020

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Background: Long noncoding RNAs (lncRNAs) have been reported to be important regulators in pathogenesis of human cancers, including nasopharyngeal carcinoma (NPC). Here, we mainly aimed to explore the mechanisms of LncRNA-SNHG5/ miR-1179/HMGB3 axis in NPC progression. Methods: RT-qPCR and Western blot analysis were employed to detect mRNA and protein expressions. CCK-8, Transwell and dual luciferase reporter assays were applied to investigate functions of LncRNA-SNHG5/miR-1179/ HMGB3 axis. Results: Upregulation of lncRNA-SNHG5 and downregulation of miR-1179 were identified in NPC, which were associated with adverse clinical outcomes. Functionally, upregulation of lncRNA-SNHG5 and downregulation of miR-1179 accelerated NPC cell proliferation, migration and invasion. Furthermore, lncRNA-SNHG5 acted as a molecular sponge of miR-1179 in NPC. Besides that, upregulation of HMGB3 was found in NPC, and knockdown of HMGB3 restrained NPC progression. Moreover, HMGB3, a target of miR-1179, regulated NPC progression by mediating LncRNA-SNHG5/miR-1179 axis. Conclusion: LncRNA SNHG5 serves as a tumor promoter in NPC by sponging miR-1179 and upregulating HMGB3.

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“…12 However, miR-500 and miR-628 promote NSCLC occurrence, migration and invasion by targeting ING1. 10 miRNAs have been found to be potential prognostic markers in NSCLC acting as either oncogenes or tumor suppressors.…”

Section: Discussionmentioning

confidence: 99%

“…11 microRNA-758 can inhibit proliferation, invasion, migration and promoted apoptosis of NSCLC by negatively regulating HMGB. 12 However, miR-500 and miR-628 promote NSCLC occurrence, migration and invasion by targeting ING1. 13 However, the specific role of MiR-605-5p in NSCLC remains unclear.…”

Section: Discussionmentioning

confidence: 99%

miR‐605‐5p promotes invasion and proliferation by targeting TNFAIP3 in non–small‐cell lung cancer

Liao

Cao

Wang

et al. 2019

J of Cellular Biochemistry

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Lung cancer is an significant cause of death worldwide, and non–small‐cell lung cancer (NSCLC) is the most common type of lung cancer. MicroRNAs (miRNAs) have been identified to play key roles in NSCLC development. Recently, it has been reported that miR‐605‐5p is a cancer‐related miRNA in several types of tumors. In this study, we study the role of miR‐605‐5p in NSCLC cells. We find that miR‐605‐5p is upregulated in NSCLC cells. Overexpression of miR‐605‐5p significantly promotes lung cancer invasion and migration in H460 and H1299 cells. Besides this, miR‐605‐5p also promotes lung cancer cell carcinoma proliferation and metastasis in vivo. However, downregulation of miR‐605‐5p inhibits cell invasion and migration by inhibiting lung cancer cell carcinoma proliferation and metastasis. In addition, the luciferase report assay identifies 3′‐untranslated region tumor necrosis factor α‐induced protein 3 (TNFAIP3) as a target of miR‐605‐5p. Silencing of TNFAIP3 promotes invasion and proliferation in lung cancer. In addition, the knockdown of TNFAIP3 restores the significant decrease in invasion and proliferation in miR‐605‐5p‐inhibitor–transfected lung cancer cells. In conclusion, miR‐605‐5p promotes invasion and proliferation by targeting TNFAIP3 in NSCLC, and may provide possible biomarkers for NSCLC therapy.

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Overexpression of miR-758 inhibited proliferation, migration, invasion, and promoted apoptosis of non-small cell lung cancer cells by negatively regulating HMGB

Cited by 25 publications

References 42 publications

miR‐155‐5p and miR‐760 mediate radiation therapy suppressed malignancy of non‐small cell lung cancer cells

miR‐155‐5p and miR‐760 mediate radiation therapy suppressed malignancy of non‐small cell lung cancer cells

LncRNA SNHG5 promotes nasopharyngeal carcinoma progression by regulating miR-1179/HMGB3 axis

miR‐605‐5p promotes invasion and proliferation by targeting TNFAIP3 in non–small‐cell lung cancer

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