Overexpression of Wnt7a Is Associated With Tumor Progression and Unfavorable Prognosis in Endometrial Cancer

Liu, Yunduo; Meng, Fanling; Yang, Xu; Yang, Shanshan; Xiao, Min; Chen, Xiuwei; Lou, Ge

doi:10.1097/igc.0b013e31827c7708

Cited by 36 publications

(39 citation statements)

References 20 publications

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“…In tissues, WNT7A expression was found higher in ovarian cancer compared with normal ovaries and benign tumors [16,38], as well as overexpressed in endometrial cancer compared with normal endometrium and benign endometrial lesion [39].…”

Section: Discussionmentioning

confidence: 98%

Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration

Ramos-Solano

Meza-Canales

Torres-Reyes

et al. 2015

Experimental Cell Research

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Section: Discussionmentioning

confidence: 98%

Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration

Ramos-Solano

Meza-Canales

Torres-Reyes

et al. 2015

Experimental Cell Research

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“…20 It was reported that sFRP expression is reduced by epigenetic inactivation in several cancer types. 21–25 21–25 21–25 21–25 21–25 Until now, there is no study investigating the relationship between sFRP4 SNPs and LC. So, this is the first study in this subject.…”

Section: Discussionmentioning

confidence: 99%

Significant Association between Polymorphisms of Wnt Antagonist Genes and Lung Cancer

Yilmaz

Dönmez

Kaçan

et al. 2015

Journal of Investigative Medicine

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Further elucidation of the molecular mechanisms underlying lung cancer (LC) is essential for the development of new effective therapeutic agents. Recently, involvement of Wnt antagonists in oncogenesis has been demonstrated in several cancers. The investigation of their contribution to lung carcinogenesis is still under investigation. We aimed to investigate whether there is a susceptibility or preventive effect of Wnt antagonist gene polymorphisms on the development and/or prognosis of LC. We investigated 110 LC patients and 160 controls. Single-nucleotide polymorphisms of Wnt antagonist genes including DKK2 (rs17037102), DKK3 (rs3206824), DKK3 intron4 G/C (rs7396187), DKK4 (rs2073664), and sFRP4 (rs1802074) were analyzed using nested polymerase chain reaction and restriction fragment length polymorphism. Results showed that patients with DKK3 AA compared with controls have a decreased risk of LC (adjusted for smoking habit, body mass index, and familial history) (P = 0.02; odds ratio [OR],0.08; 95% confidence interval [95% CI], 0.01-0.7). It was found that, for sFRP4 polymorphism, patients with GG and GA genotypes versus AA genotype controls showed a decreased risk for LC (P = 0.01; [OR, 0.19; 95% CI, 0.05-0.73 for GG genotype]; [OR = 0.18, 95% CI, 0.04-0.72 for GA genotype]). In addition, a decreased risk of LC was also found for the genotype combination of DKK3 (rs3206824) GG and sFRP4 AG + GG (P = 0.004; OR, 0.12; 95% CI, 0.02-0.58). We suggest that these 2 polymorphisms have a protective effect on LC in this study.

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“…Two immunohistochemical studies investigated the expression of ligand WNT7A. The first study found that WNT7A was overexpressed (27), and the second study revealed the decrease in the expression in endometrial cancer (28). We detected a downregulated expression of CTNNB1 and AXIN2 genes in stage I adenocarcinoma samples, but no significant changes in the protein level in most of the patients.…”

Section: Discussionmentioning

confidence: 74%

Changes in the expression of Notch and Wnt signalling molecules in human endometrial cancer

Lachej¹,

Jonušienė²,

Mažeikė³

et al. 2020

AML

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Background. Endometrial cancer is the sixth most frequent type of cancer among women worldwide. Type I adenocarcinomas account for 80–85% of endometrial cancer cases and sometimes require more aggressive treatment than the remaining part of this group. Therefore, molecular markers to stratify adenocarcinomas are needed. Materials and methods. In this study, we analysed Notch and Wnt signalling in human endometrial cancer cases to evaluate these pathway elements as potential biomarkers for type I endometrial cancer. Endometrial samples were obtained from 47 women undergoing surgery for stage I–IV endometrial cancer in the National Cancer Institute (Vilnius, Lithuania) in 2015–2016. The expression at the mRNA level of signalling molecules genes (NOTCH1, NOTCH2, NOTCH3, NOTCH4, JAG1, JAG2, DLL1, HES1, AXIN2 and CTNNB1) was analysed by the quantitative real-time polymerase chain reaction. Relative expression of NOTCH1, NOTCH4, HES1 and β-catenin proteins in endometrioid adenocarcinoma was evaluated by the Western blot method. Results. The expression level of Notch receptors, ligands, and the target gene, as well as CTNNB1 and AXIN2, was reduced in stage I endometrioid adenocarcinoma if compared to the adjacent non-tumour tissue. The expression of all receptors, ligands, and target molecules was reduced in adenocarcinomas of later stages. The statistically significant correlations between transcript amounts of Notch receptors and ligands were found. There was a statistically significant difference in the gene expression of Notch signalling pathway components between different tumour differentiation grade samples. A positive correlation between mRNA and protein the expression level of NOTCH1, NOTCH4, HES1 was determined in stage I samples. Conclusions. Analysis of 47 human endometrial cancer samples revealed a reduction in the transcript levels of Notch and Wnt signalling molecule compared to the adjacent non-tumour tissue. These results suggest tumour suppressor function of Notch and Wnt signalling in human endometrial cancer. More detailed research on these signalling pathways should reveal their importance as potential biomarkers.

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Overexpression of Wnt7a Is Associated With Tumor Progression and Unfavorable Prognosis in Endometrial Cancer

Abstract: Overexpression of Wnt7a may contribute to the progression of endometrial cancer and thus may serve as a new biomarker to predict the prognosis of endometrial cancer.

Cited by 36 publications

References 20 publications

Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration

Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration

Significant Association between Polymorphisms of Wnt Antagonist Genes and Lung Cancer

Changes in the expression of Notch and Wnt signalling molecules in human endometrial cancer

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