Overview of blood components and their preparation

Abstract

The whole blood which is a mixture of cells, colloids and crystalloids can be separated into different blood components namely packed red blood cell (PRBC) concentrate, platelet concentrate, fresh frozen plasma and cryoprecipitate. Each blood component is used for a different indication; thus the component separation has maximized the utility of one whole blood unit. Different components need different storage conditions and temperature requirements for therapeutic efficacy. A variety of equipments to maintain suitable ambient conditions during storage and transportation are in vogue. The blood components being foreign to a patient may produce adverse effects that may range from mild allergic manifestations to fatal reactions. Such reactions are usually caused by plasma proteins, leucocytes, red cell antigens, plasma and other pathogens. To avoid and reduce such complications, blood products are modified as leukoreduced products, irradiated products, volume reduced products, saline washed products and pathogen inactivated products. The maintenance of blood inventory forms a major concern of blood banking particularly of rare blood groups routinely and common blood groups during disasters. PRBCs can be stored for years using cryopreservation techniques. New researches in red cell cultures and blood substitutes herald new era in blood banking.

Antimicrobial activity and safety evaluation of peptides isolated from the hemoglobin of chickens

“…The whole blood is a mixture of cells (erythrocytes, leucocytes and platelets) and plasma (colloids and crystalloids), which delivers nourishment and oxygen to and removes waste products from all parts of the body [7]. Components in blood, such as platelet concentrates [8], defensins [3], leukocyte extracts [9], also play important roles in antimicrobial host defense.…”

Quality Analysis of Blood Component (Prbc and Platelet Concentrates): A Study From a Tertiary Care Teaching Hospital of Kumaon Region of Uttarakhand

“…6 Various techniques like leuko-reduction have been reported to make blood transfusion safer. 7 The components in our study had minimal leukocytes thus providing enhanced effects and safety.…”

Blood Components as Joint Products: A Literature Review of Cost-Allocation Methods

“…By centrifuging whole blood, one unit of red cells, one unit of fresh frozen plasma, and one unit of buffy coat (for platelet production) are obtained. By apheresis, a single component or multiple components are collected directly from the donor, and the rest of the blood components are returned to the donor (Basu & Kulkarni, 2014). With this technique (EU Recommendation No.…”

“…After the split-off point, the final processes for each of the blood products are storage and distribution for clinical use (Schotnitzer, 2005). Before being assigned for transfusion, blood products can be adapted or treated according to their intended therapeutic use; examples of subsequent manufacturing process are: leucodepletion irradiation, filtration (Basu & Kulkarni, 2014). The production process for blood components for clinical use follows a two-step process: one associated with the blood component preparation and one connected with transfusion services (Participants of the Charleston, 2005).…”