Overview of Childhood Cancers at a Regional Cancer Centre in North-East India

Hazarika, Munlima; Krishnatreya, Manigreeva; Bhuyan, Cidananda; Saikia, Bedangshu; Kataki, Amal Chandra; Nandy, Pintu; Hazarika, Monalisha; Roy, Partha

doi:10.7314/apjcp.2014.15.18.7817

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…In this study most of cases were in age group of 10-14 years (35%), Similar finding was seen in a study by Rajpal et al showed similar results in the age group of 10-14 years (58.18%) [14] .This result is contrary to study done by others in which most cases were between to 5-9 years age group [7,11,15]. Some Studies found most common age is 0-4 years [13,16].…”

Section: Discussionsupporting

confidence: 82%

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Spectrum of pediatric malignancy- A cancer hospital-based study

et al. 2020

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Objective: Childhood malignancy being a significant cause of mortality among children. The aim of the study is to find out the epidemiology of tumours in children in our region below <14 years age who presented to tertiary care Cancer hospital, Bhopal, M.P. for period of four years (2015)(2016)(2017)(2018). Methodology: All children with cancer, aged 1-14 years diagnosed by mean of histological and cytological examination during a period of 4 years were reviewed. Results: During the period of four years 275 patients were diagnosed as having paediatric malignancies. According to year wise distribution highest incidence of cases were found in 2016 (32.72%). The highest number of cases, 96(35%) were in 10-14 years of age group and mean age was 7.43 with SD 4.0. Male were affected more than females with ratio of 2.66:1. It was observed that haematological malignancies were more common 172(62.54%) than the non haematological malignancies 103(37.45%). Leukemia 150 (54.54%) is most common pediatric cancer amongst which Acute lymphoblastic leukemia is most common haematological malignancy. Overall, it was found that most common cancer group in the present study were leukemia (54%) followed by lymphoma (8.36%), Brain tumours (7.27%) and Sarcoma (7.27%). Conclusion: Although the exact incidence rate cannot be provided by this hospital-based study, the information is useful in showing distribution patterns of childhood malignancy in this region.

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Section: Discussionsupporting

confidence: 82%

“…This result is contrary to study done by Jabeen et al showed that Lymphoma (24.2%) followed by Retinoblastoma (17.4%), leukemia (14.3%) [10]. Study by Munlima et al showed that most common cancer group was leukemia (26.9%) followed by Retinoblastoma (15.9%), CNS tumour (14.5%), Lymphoma (13.1%) [11].…”

Section: Discussionmentioning

confidence: 68%

Spectrum of pediatric malignancy- A cancer hospital-based study

et al. 2020

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“…Globally, the incidence of cancer in children differs from 48 to 70 per million children less than 15 years of age [3]. The incidence of childhood cancer in some developed countries, such as in United State, Ireland, Switzerland, and in Australia has reported with rates of 15.3, 13, 13.5, and 16 per 100,000 children, respectively, however in Asia the data are generally lower [4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Pediatric Cancer Patients

Hegazy

Bar

Alamri

et al. 2019

JAMMR

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Background: In recent years the survival rates for children diagnosed with cancer has increased as result of successful treatment. Evaluation of health related quality of life during the process of treatments is important for recognition of acute dysfunction related to therapy and disease. Aim: Aim of the study is to identify the health-related quality of life in pediatric cancer patients and to detect the potential predictors of a total quality of life and its domains. Materials and Methods: It is a cross-sectional study done on convenient sample of pediatric cancer patients. Their diagnosis was confirmed at pediatric hematology clinic and day care unit at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Results: A total number of 51 children participated in this study, their age ranging from 8-15 years with mean 10.15± 2.52. Hematological malignancies represented 70.5% of the sample, with the highest percentage for acute lymphocytic leukemia (45%). The mean value of the total quality of life is 73.48, which is referred to as a good quality of life. The best scores of subscales were cognitive problems (92.54), communication (82.67), and nausea (76.86), otherwise poorer score was detected. Although the value of total quality of life was relatively good however visiting the hospital more than 3 times per month, male gender, duration of therapy and duration of diagnosis more associated with more pain and hurt, great worry and treatment anxiety. Conclusion: Higher frequency of hospital visits, male gender, longer duration of diagnosis, longer duration of therapy, and increased intensity of therapy were all associated with more pain and hurt, great worry, nausea, and treatment anxiety which reflect a poor quality of life among the study group.

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“…The methodology in the remaining eight was not reported . Eight studies defined abandonment, ranging from missing two appointments to missing four weeks of therapy . Only 13 studies actively followed up cases of abandonment to minimize misclassification …”

Section: Overall Resultsmentioning

confidence: 99%

“…One hundred thirteen studies did not have a primary objective of investigating genetic/biochemical prognosticators; ARs were available for 38 (33.6%) of these studies (Supporting Information missing two appointments to missing four weeks of therapy. 5,6,[15][16][17][18][19][20] Only 13 studies actively followed up cases of abandonment to minimize misclassification. 5,6,11,15,16,18,[20][21][22][23][24][25][26]…”

Section: Overall Resultsmentioning

confidence: 99%

The magnitude and predictors of therapy abandonment in pediatric central nervous system tumors in low‐ and middle‐income countries: Systematic review and meta‐analysis

Seah

Zhang

Halbert

et al. 2019

Pediatric Blood & Cancer

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Background Outcomes of pediatric central nervous system (CNS) tumors in low‐ to middle‐income countries (LMIC) are poorer than their high‐income counterparts. Abandonment of therapy is increasingly recognized as a key contributor to this disparity, but has been poorly quantified. We performed a meta‐analysis to determine the magnitude of abandonment in pediatric CNS tumors in LMIC, and risk factors and interventions aimed at reducing this. Patients and methods We searched seven databases for pediatric CNS tumor cohorts followed up from diagnosis and treated in LMIC. All languages were included. Two reviewers independently selected articles and extracted data on abandonment rates (ARs) and predictors. The authors were contacted for additional information. Results Of 50 660 publications, 643 in five languages met criteria for full review; 131 met analysis inclusion criteria. ARs were not reported in the majority, and a small number were available from the authors. Available ARs ranged from 0% to 59%, from 38 studies (2497 children in 14 countries), and these were quantitatively analyzed. Lower‐middle‐income countries had higher ARs than upper‐middle‐income countries (27%, 95% confidence interval [CI] 20%–36% vs 9%, 95% CI 6%–14%, P < 0.0001), with significant heterogeneity within each (LMIC I2 = 78%, P < 0.00001, UMIC I2 = 85%, P < 0.00001). Common predictors for abandonment included distance to treatment centers, financial hardship, and prognostic misconceptions. Conclusion In LMICs, ARs are highest in lower‐MICs. However, the paucity of published data limits further evaluation. Given the increasing burden of pediatric CNS tumors in LMIC, addressing deficits in abandonment reporting is critical. Consistent reporting is needed for developing interventions to improve outcomes.

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Overview of Childhood Cancers at a Regional Cancer Centre in North-East India

Cited by 11 publications

References 9 publications

Spectrum of pediatric malignancy- A cancer hospital-based study

Spectrum of pediatric malignancy- A cancer hospital-based study

Quality of Life in Pediatric Cancer Patients

The magnitude and predictors of therapy abandonment in pediatric central nervous system tumors in low‐ and middle‐income countries: Systematic review and meta‐analysis

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