Overview of Lung Transplantation, Heart-Lung Transplantation, Liver-Lung Transplantation, and Combined Hematopoietic Stem Cell Transplantation and Lung Transplantation

Gadre, Shruti; Turowski, J; Budev, Marie

doi:10.1016/j.ccm.2017.07.004

Cited by 15 publications

(8 citation statements)

References 65 publications

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“…O transplante de pulmão (LTX) é uma opção de tratamento apropriada para pacientes com doença pulmonar em estágio terminal. (1) Embora novos tratamentos e biomarcadores prognósticos estejam disponíveis, pacientes com fibrose pulmonar idiopática (FPI), doença pulmonar obstrutiva crônica (DPOC) ou fibrose cística (FC) ainda são os que mais obtêm benefícios. (2)(3)(4)(5)(6)(7) A fibrose pulmonar familiar (FPF) é definida como uma doença pulmonar intersticial idiopática que afeta dois ou mais membros da mesma família.…”

Section: Introductionunclassified

Lung transplant in patients with familial pulmonary fibrosis

Bennett¹,

Fossi²,

Lanzarone³

et al. 2020

J Bras Pneumol.

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Objective: Familial pulmonary fibrosis (FPF) is defined as an idiopathic interstitial lung disease affecting two or more members of the same family; poor outcome with high risk of death and chronic lung allograft dysfunction (CLAD) after lung transplant has been reported in these patients. The present study aimed to compare the short- and long term outcome of lung transplants in patients with FPF and patients transplanted because of other interstitial lung diseases. Method: Clinical pre- and post-transplant data from 83 consecutive patients with pulmonary fibrosis who underwent lung transplant at our centre were collected retrospectively. Patients were divided into those with familial (n=9 FPF group) and those with non-familial pulmonary fibrosis (n=74 controls). Results: The FPF group was composed of 4 females and 5 males; 44.5% were ex-smokers. The majority presented their CT scan and pathology evidence of usual interstitial pneumonia. Patients with FPF had significantly lower pre-transplant levels of haemoglobin and haematocrit. No other differences in pre- and post-transplant characteristics were observed concerning controls. The clinical post-operative course was similar in the two groups. No significant difference in one-year CLAD-free survival and overall survival was observed. Conclusion: The post-transplant course of patients with FPF was similar to patients with non-familial pulmonary fibrosis, although more patients with FPF had pre-transplant anaemia. Short- and long-term outcome was comparable in both groups. Lung transplant proved to be a valid option for patients with FPF as it was for patients with other types of pulmonary fibrosis.

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Section: Introductionunclassified

Lung transplant in patients with familial pulmonary fibrosis

Bennett¹,

Fossi²,

Lanzarone³

et al. 2020

J Bras Pneumol.

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“…The most common indication for CLLT is cystic fibrosis with pulmonary and liver involvement. Other indications include POPH with ESLD, hepatopulmonary fibrosis, alpha-1 antitrypsin deficiency with advanced lung and liver involvement, and sarcoidosis [64]. As with CHLT, there is a postulated immunological benefit for combined transplant, where LT is immune protective [65,66].…”

Section: Combined Liver and Thoracic Transplantationmentioning

confidence: 99%

“…As with CHLT, there is a postulated immunological benefit for combined transplant, where LT is immune protective [65,66]. There are no standardized recommendations available for CLLT, and candidacy is evaluated at each center with a multidisciplinary board committee review [64]. Potential CLLT candidates need to be placed on individual organ wait-lists.…”

Section: Combined Liver and Thoracic Transplantationmentioning

confidence: 99%

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Liver Transplantation

Bleszynski

Kim

2019

The Critically Ill Cirrhotic Patient

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“…LUNG TRANSPLANTATION is increasingly used in late‐ to endstage pulmonary disease . However, due to postoperative and long‐term complications, the median survival of 5.8 years is still unsatisfactory .…”

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confidence: 99%

Can texture analysis in ultrashort echo‐time MRI distinguish primary graft dysfunction from acute rejection in lung transplants? A multidimensional assessment in a mouse model

Euler

Blüthgen

Wurnig

et al. 2019

Magnetic Resonance Imaging

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Background: Differentiation of early postoperative complications affects treatment options after lung transplantation. Purpose: To assess if texture analysis in ultrashort echo-time (UTE) MRI allows distinction of primary graft dysfunction (PGD) from acute transplant rejection (ATR) in a mouse lung transplant model. Study Type: Longitudinal. Animal Model: Single left lung transplantation was performed in two cohorts of six mice (strain C57BL/6) receiving six syngeneic (strain C57BL/6) and six allogeneic lung transplants (strain BALB/c (H-2K d )). Field Strength/Sequence: 4.7T small-animal MRI/eight different UTE sequences (echo times: 50-5000 μs) at three different postoperative timepoints (1, 3, and 7 days after transplantation). Assessment: Nineteen different firstand higher-order texture features were computed on multiple axial slices for each combination of UTE and timepoint (24 setups) in each mouse. Texture features were compared for transplanted (graft) and contralateral native lungs between and within syngeneic and allogeneic cohorts. Histopathology served as a reference. Statistical Tests: Nonparametric tests and correlation matrix analysis were used. Results: Pathology revealed PGD in the syngeneic and ATR in the allogeneic cohort. Skewness and low-gray-level runlength features were significantly different between PGD and ATR for all investigated setups (P < 0.03). These features were significantly different between graft and native lung in ATR for most setups (minimum of 20/24 setups; all P < 0.05). The number of significantly different features between PGD and ATR increased with elapsing postoperative time. Differences in significant features were highest for an echo-time of 1500 μs. Data Conclusion: Our findings suggest that texture analysis in UTE-MRI might be a tool for the differentiation of PGD and ATR in the early postoperative phase after lung transplantation. Level of Evidence: 1 Technical Efficacy: Stage 3

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Overview of Lung Transplantation, Heart-Lung Transplantation, Liver-Lung Transplantation, and Combined Hematopoietic Stem Cell Transplantation and Lung Transplantation

Cited by 15 publications

References 65 publications

Lung transplant in patients with familial pulmonary fibrosis

Lung transplant in patients with familial pulmonary fibrosis

Liver Transplantation

Can texture analysis in ultrashort echo‐time MRI distinguish primary graft dysfunction from acute rejection in lung transplants? A multidimensional assessment in a mouse model

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