Oxalosis of bone

Wiggelinkhuizen, J; Fisher, R. M.

doi:10.1007/bf00973200

Cited by 13 publications

(5 citation statements)

References 3 publications

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“…Moreover the respective role of oxalate crystal deposition and uremic hyperparathyroidism in the genesis of bone lesions is undefined. The earliest specific radiographic skeletal features of oxalosis are fine transverse lines of increased bone density, located symmetrically in the areas of rapid growth, presumably related to crystal precipitation in the site where cartilage normally calcifies (8). These findings are most prominent in areas of hematopoietic rather than fatty marrow and other highly vascularized areas, where blood oxalic acid levels are greater.…”

Section: Discussionmentioning

confidence: 99%

Primer hiperoksalüri

2017

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Hyperoxaluria is characterized by nephrolithasis and nephrocalcinosis caused by supersaturation of calcium oxalate in the urine. Deposits of calcium oxalate can lead to kidney damage, kidney failure, and injury to other organs. Herein, we report a case of primary hyperoxaluria which is a serious though rare condition, can be suspected on the basis of the renal features. Radiological skeletal changes, which are also rather specific, may also share some features with renal osteodystrophy.

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Section: Discussionmentioning

confidence: 99%

Primer hiperoksalüri

2017

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“…Fractures also may occur spontaneously in these regions of weakness. The translucent rims noted around the small bones, such as the vertebrae, the tarsal or carpal bones, reflect the slower growth rate in these regions [33].…”

Section: Discussionmentioning

confidence: 99%

“…Of our severely affected children, 2 presented pathological fractures that occurred in regions of metaphyseal lucencies. The femoral neck seems to be a zone of predilection for such fractures [15, 21, 26, 31, 33, 34]. Internal fixation of those lower limb fractures interfering with weight bearing transformed the quality of life of these children who had become bedridden.…”

Section: Discussionmentioning

confidence: 99%

Skeletal features of primary hyperoxaluria type 1, revisited

Hage

Ghanem

Baradhi

et al. 2008

Journal of Children's Orthopaedics

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Purpose The purpose of this study was to describe the skeletal manifestations of primary hyperoxaluria type 1 (PH1), the most common of the primary hyperoxalurias. Methods We clinically and radiographically reviewed 12 consecutive patients diagnosed with PH1, aged between 2 and 17 years. All patients had evidence of some type of renal involvement, 4 of whom were at end-stage renal disease (ESRD) and were under dialysis. Results The main symptom was skeletal pain and was present only in the 4 severely involved patients and appeared during the second year of dialysis. The 2 most severely involved patients had evidence of pathological fractures. Radiological signs were present in patients with or without symptoms. These radiological signs were of two distinct types: those almost specific of oxalosis, such as dense and radiolucent metaphyseal bands and vertebral osteocondensations, which are found mainly in the severely involved individuals, and those less specific, such as signs of renal osteodystrophy, which are also found in less severely involved patients. Interestingly, our study revealed the presence of spondylolysis in 25% of cases. This latter finding is unique and has not previously been reported in the literature. Conclusions The skeletal manifestations of PH1 include specific and less specific radiological signs, with some patients being asymptomatic, and others presenting with bone pain and pathological fractures, as well as spondylolysis.

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“…Under X-ray, characteristics of oxalate osteopathy include dense metaphyseal bands, submarginal metaphyseal lucency, sclerosis of adjacent diaphysis, cystic bone changes, deformities, subperiosteal resorption, blurred trabecular pattern, and increased bone density in vertebra and iliac crest [17][18][19]. Symmetrical transverse lines of increased bone density at areas of rapid growth have been related to crystalline precipitation in cartilage calcification sites as well as in hematopoietic and other highly vascularized areas [17,[20][21][22].…”

Section: Conventional Radiological Evaluation Of Patients With Ph1mentioning

confidence: 99%

Bone impairment in primary hyperoxaluria: a review

2015

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Deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria (PH). Since the bone compartment can store massive amounts of oxalate, patients present with recurrent low-trauma fractures, bone deformations, severe bone pains, and specific oxalate osteopathy on X-ray. Bone biopsy from the iliac crest displays specific features such as oxalate crystals surrounded by a granulomatous reaction corresponding to an invasion of bone surface by macrophages. The objective of this manuscript is therefore to provide an overview of bone impairment in PH, by reviewing the current literature on bone and dental symptoms as well as imaging techniques used for assessing bone disease.

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Oxalosis of bone

Cited by 13 publications

References 3 publications

Primer hiperoksalüri

Primer hiperoksalüri

Skeletal features of primary hyperoxaluria type 1, revisited

Bone impairment in primary hyperoxaluria: a review

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