Oxidant / Antioxidant Status in Patients with Psoriasis

Abstract

Psoriasis is a common, chronic inflammatory skin disease with unknown etiology. Recently it has been suggested that increased ROS production and deficient function of antioxidant systems activities may be involved in the pathogenesis of the disease. Although there are several studies investigating oxidant/antioxidant systems in psoriatic patients, the data obtained from these studies is not concordant. In this study, superoxide dismutase (SOD) enzyme activity, and malondialdehyde (MDA) and antioxidant potential (AOP) levels in thirty-five patients with psoriasis were investigated and compared with those of twenty-four control subjects. Clinical severity of the disease was determined according to the Psoriasis Area and Severity Index (PASI) scores in the patients. Plasma SOD activity and MDA levels were significantly higher (p=0.012 and p=0.005 respectively), whereas AOP levels were lower, in patients than controls (p=0.001). There was no correlation between PASI scores and plasma SOD, MDA, and AOP levels. Our findings may provide some evidence for a potential role of increased ROS production and decreased antioxidant activity in psoriasis.

The Serum Levels of Malondialdehyde, Vitamin E and Erythrocyte Catalase Activity in Psoriasis Patients

“…Numerous studies found significantly decreased levels of serum Vitamin E [15][16][17] and erythrocyte catalase activity [18][19][20][21] in psoriasis patients. Whereas some research work did not found any significant change in the levels of antioxidants like serum vitamin E [16][17][18][19][20][21][22] and erythrocyte catalase activity [23] in psoriasis patients.…”

“…Whereas some research work did not found any significant change in the levels of antioxidants like serum vitamin E [16][17][18][19][20][21][22] and erythrocyte catalase activity [23] in psoriasis patients.…”

“…These effects of oxidative stress all together might be responsible for epidermal proliferation [20,[28][29][30].…”

Food, Nutrition and Diet Therapy in Psoriasis

“…Oxidative stress and the increased formation of free radicals have been related to skin inflammation and are reported to be among the most important factors in the pathogenesis of psoriasis (Kiymat et al, 2003;Rocha et al, 2004;Relhan et al, 2002;Wolters, 2005). Studies demonstrate that individuals with psoriasis have high concentrations of malondialdehyde, OuvirLer foneticamentea marker of lipid peroxidation, and is compromised antioxidant status, with reduced levels of -carotene, -tocopherol and selenium (Azzini et al, 1995;Briganti & Picardo, 2003;Serwin et al, 2003).…”

Study of serum carbonic anhydrase activity, uric acid, C-reactive protein levels and lipid parameters in patients with Psoriasis

“…25 Recently it has been suggested that increased reactive oxygen species (ROS) production and deficient function of antioxidant systems activities may be involved in the pathogenesis of the disease. 26 The carbonic anhydrase enzyme has recently been reported to have an anti-oxidant activity, which is glutathione- Original Article NJDVL -21 mediated. 27 Our earlier study demonstrated that the carbonic anhydrase activity had a strong correlation with lipid parameters.…”