Oxidative DNA damage during night shift work

Bhatti, Parveen; Mirick, Dana K.; Randolph, Timothy W.; Gong, Jicheng; Buchanan, Diana Taibi; Zhang, Junfeng Jim; Davis, Scott

doi:10.1136/oemed-2017-104414

Cited by 36 publications

(27 citation statements)

References 11 publications

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“…A previous study has shown that melatonin, which plays a major role in the regulation of the circadian wake-sleep cycle (Ortiz et al 2011), was lower in night shift workers than that of workers without night shift (Bhatti et al 2017). It has also been reported that the urinary melatonin level was positively associated with sperm concentration (Ortiz et al 2011) and the cellular oxidative DNA damage repair capacity (Bhatti et al 2017). The findings of our study and previous studies together suggest a significant association between sleep quality and sperm quality, probably both occurring as a result of disturbed melatonin secretion.…”

Section: Discussionmentioning

confidence: 93%

Lifestyle and demographic factors associated with human semen quality and sperm function

Shi

Chan

Waters

et al. 2018

Systems Biology in Reproductive Medicine

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BMI: body mass index; SA: semen analysis; AR: acrosome reaction; DFI: DNA fragmentation index; GAM: generalized additive model; TSC: total sperm count; TMC: total motile sperm count; IUI: intrauterine insemination; SCSA: sperm chromatin structure assay; SD: standard deviation; IQR: interquartile range; CBAVD: congenital bilateral absence of vas deferens; NEQAS: national external quality assessment service; HTF: human tubal fluid; HSA: human serum albumin.

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Section: Discussionmentioning

confidence: 93%

Lifestyle and demographic factors associated with human semen quality and sperm function

Shi

Chan

Waters

et al. 2018

Systems Biology in Reproductive Medicine

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“…34 A previous study showed that the melatonin was higher in workers without night shift, than those with night shift. 35 Another study 36 reported that the melatonin level in urine was positively correlated with sperm concentration. Consistent with these two studies, our findings demonstrated that melatonin and circadian system play an important role in determining male reproduction.…”

Section: Discussionmentioning

confidence: 99%

<p>Association Between Sleep Quality and Semen Parameters and Reproductive Hormones: A Cross-Sectional Study in Zhejiang, China</p>

Du¹,

Yang²,

Chen³

et al. 2020

NSS

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Background: The effects of sleep duration on semen quality have been documented in many epidemiological studies. However, the association between sleep quality and semen parameters and reproductive hormones is still unclear. Patients Enrollment and Methods: We conducted a cross-sectional study among 970 outpatients from the Reproductive Medicine Center in Zhejiang, China between October 2017 and July 2019. All participants delivered a semen sample, underwent a physical examination, and answered a questionnaire to provide the following information: demographics, life habits, and sleep habits. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). We first divided the patients into two groups according to sleep quality (good sleep: PQSI < 5 and poor sleep: PSQI ≥ 5). Then, we analyzed routine sperm parameters (semen volume, sperm total motility, progressive motility, sperm concentration, total sperm number, and normal sperm morphology) and reproductive hormones (folliclestimulating hormone, luteinizing hormone, estrogen, testosterone, and prolactin) of each group. Finally, we used multivariate linear regression analysis and Spearman correlation coefficients to examine the relationship between sleep quality (discrete variable or dichotomous variable) and sperm parameters, reproductive hormones. Results: A negative correlation was found between the general PSQI scores and several semen parameters: total motility (r= −0.187979, p< 0.001), progressive motility (r= −0.192902, p< 0.001), concentration (r= −0.167063, p< 0.001), total sperm number (r= −0.160008, p< 0.001), and normal sperm morphology (r= −0.124511, p< 0.001). However, there was no significant correlation between the semen volume, all reproductive hormones and the general PSQI scores. After adjusting for confounders, men with poor sleep had lower total motility (β= −9.287; 95% CI, −12.050, −6.523), progressive motility (β= −8.853; 95% CI, −11.526, −6.180), concentration (log scale, β= −0.131; 95% CI, −0.181, −0.082), total sperm number (log scale, β= −0.137; 95% CI, −0.189, −0.084), and normal sperm morphology (β= −1.195; 95% CI, −1.844, −0.547), but semen volume and all reproductive hormones were not markedly altered. Conclusion: Poor sleep quality might be related to impaired semen quality, but we found no evidence that poor sleep quality affects reproductive hormones.

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“…These findings could be related to circadian disruption, which has been linked to dysregulation of gene transcription of the Circadian Locomotor Output Cycles Kaput (CLOCK) genes [22] in which single nucleotide polymorphisms have been linked to reduced semen volume, sperm count, and sperm motility [23]. The disruption of the circadian rhythm has also been associated with lower levels of urinary 8hydroxydeoxyguanosine likely caused by reduced melatonin levels indicating a reduced ability to repair oxidative deoxyribonucleic acid (DNA) damage which is important for fertility [24]. In line with this, Shi et al [13] found a higher DNA fragmentation index (DFI) in men with irregular sleep.…”

Section: Bedtimementioning

confidence: 99%

Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study

Hvidt

Knudsen

Zachariae

et al. 2020

Basic Clin. Androl.

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Background: Poor sleep has been linked to a number of adverse health outcomes. Recent studies suggest that late bedtimes, short or long sleep durations, and poor sleep quality may impair semen quality. No study has previously explored all three factors in relation to semen quality. Results: One hundred and four men and their partners treated at three fertility clinics in Denmark between 2010 and 2012 completed an online-version of the Pittsburgh Sleep Quality Index (PSQI). The results of the semen analyses conducted at the fertility clinics were self-reported and categorised as normal or reduced. Early bedtime (< 10:30 PM) was more often associated with normal semen quality compared with both regular (10:30 PM-11:29 PM) and late (≥11:30 PM) bedtime (OR: 2.75, 95%CI: 1.1-7.1, p = 0.04 and OR: 3.97, 95%CI: 1.2-13.5, p = 0.03). Conventional sleep duration (7.5-7.99 h) was more often associated with normal semen quality than both short (7.0-7.49 h) and very short (< 7.0 h) sleep duration (OR: 1.36, 95% CI: 1.2-12.9, p = 0.03 and OR: 6.18, 95%CI: 1.6-24.2, p = 0.01). Although poor sleep quality was associated with reduced semen quality in the descriptive statistics (p = 0.04), no differences were found between optimal (PSQI ≤6) and either borderline (PSQI 7-8) or poor (PSQI ≥9) sleep quality (OR: 1.19, 95%CI: 0.4-3.4, p = 0.75 and OR: 2.43, 95%CI: 0.8-7.1, p = 0.11) in multivariate regression models. Conclusion: Early bedtimes (< 10:30 PM) and conventional sleep duration (7.5-7.99 h) were associated with selfreported normal semen quality. The role of subjective sleep quality remains uncertain.

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Oxidative DNA damage during night shift work

Cited by 36 publications

References 11 publications

Lifestyle and demographic factors associated with human semen quality and sperm function

Lifestyle and demographic factors associated with human semen quality and sperm function

<p>Association Between Sleep Quality and Semen Parameters and Reproductive Hormones: A Cross-Sectional Study in Zhejiang, China</p>

Associations of bedtime, sleep duration, and sleep quality with semen quality in males seeking fertility treatment: a preliminary study

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