Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle

Hütter, Eveline; Skovbro, Mette; Lener, Barbara; Prats, Clara; Rabøl, Rasmus; Dela, Flemming; Jansen‐Dürr, Pidder

doi:10.1111/j.1474-9726.2007.00282.x

Cited by 139 publications

(143 citation statements)

References 48 publications

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“…In fact, some studies using permeabilized myofiber bundles from human vastus lateralis muscle have found no effect of age on maximal mitochondrial respiratory capacity (Gouspillou et al 2014;Hütter et al 2007). Interestingly, one such study reported a muscledependent decrease in state III respiration with age in rats, such that muscles with a slower phenotype exhibit a reduced oxidative capacity with age and muscle with a faster phenotype demonstrate a propensity for preservation with age (Picard et al 2011a …”

Section: R a F Tmentioning

confidence: 99%

Heterogeneous effects of old age on human muscle oxidative capacity in vivo: a systematic review and meta-analysis

Fitzgerald

Christie

Kent

2016

Appl. Physiol. Nutr. Metab.

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https://mc06.manuscriptcentral.com/apnm-pubs Applied Physiology, Nutrition, and Metabolism D r a f t 2 ABSTRACTDespite intensive efforts to understand the extent to which skeletal muscle mitochondrial capacity changes in older humans, the answer to this important question remains unclear. To determine what the preponderance of evidence from in vivo studies suggests, we conducted a systematic review and meta-analysis of the effects of age on muscle oxidative capacity as measured noninvasively by magnetic resonance spectroscopy. A secondary aim was to examine potential moderators contributing to differences in results across studies, including: muscle group, physical activity status, and sex. Candidate papers were identified from PubMed searches (n=3,561 papers) and the reference lists of relevant papers. Standardized effects (Hedges' g) were calculated for age and each moderator using data from the 22 studies that met the inclusion criteria (n=28 effects). Effects were coded as positive when older (≥55 years) adults had higher muscle oxidative capacity than younger (20-45 years) adults. The overall effect of age on oxidative capacity was positive (g=0.171, p<0.001), indicating modestly greater oxidative capacity in old. Notably, there was significant heterogeneity in this result (Q=245.8, p<0.001; I 2 ~70-90%). Muscle group, physical activity, and sex were all significant moderators of oxidative capacity (p≤0.029). This analysis indicates that the current body of literature does not support a de facto decrease of in vivo muscle oxidative capacity in old age. The heterogeneity of study results and identification of significant moderators provide clarity regarding apparent discrepancies in the literature, and indicate the importance of accounting for these variables when examining purported age-related differences in muscle oxidative capacity.

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Section: R a F Tmentioning

confidence: 99%

Heterogeneous effects of old age on human muscle oxidative capacity in vivo: a systematic review and meta-analysis

Fitzgerald

Christie

Kent

2016

Appl. Physiol. Nutr. Metab.

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“…For example, oxidative capacity, which is one measure of mitochondrial function, has been reported by some to decline in older (O) adults (Conley et al 2000;Short et al 2005;Coggan et al 1992;McCully et al 1991;Pastoris et al 2000;Karakelides et al 2010), while others report no change with aging Larsen et al 2012b;Hutter et al 2007;Rasmussen et al 2003;Tevald et al 2010;Chilibeck et al 1998). A number of factors, including the means of assessing mitochondrial function, the health and physical activity (PA) status of the study participants, and the muscle group studied, apparently contribute to these conflicting findings (Larsen et al 2012b).…”

Section: Introductionmentioning

confidence: 99%

Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg

Tevald

Foulis

Kent

2014

AGE

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To determine the effects of age and sex on in vivo mitochondrial function of distinct locomotory muscles, the tibialis anterior (TA) and medial gastrocnemius (MG), of young (Y; 24±3 years) and older (O; 69±4) men (M) and women (W) of similar overall physical activity (PA) was compared. In vivo mitochondrial function was measured using phosphorus magnetic resonance spectroscopy, and PA and physical function were measured in all subjects. Overall PA was similar among the groups, although O (n=17) had fewer daily minutes of moderate-to-vigorous PA (p=0.001), and slowed physical function (p<0.05 for all variables), compared with Y (n=17). In TA, oxidative capacity (V max ; mM s −1 ) was higher in O than Y (p<0.001; Y= 0.90±0.12; O=1.12±0.18). There was no effect of age in MG (p =0.5; Y= 0.91 ± 0.17; O = 0.96 ± 0.24), but women had higher oxidative capacity than men (p= 0.007; M=0.84±0.18; W=1.03±0.18). In vivo mitochondrial function was preserved in healthy O men and women, despite lower intensity PA and physical function in this group. The extent to which compensatory changes in gait may be responsible for this preservation warrants further investigation. Furthermore, women had higher oxidative capacity in the MG, but not the TA.

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“…Several authors consider that the OXPHOS and maximal ETS capacity are influenced by the physical activity and the body mass index of the subject [33,34]. Votion et al showed lower respirometric parameters in overweight and untrained horses than in competition horses [29].…”

Section: Discussionmentioning

confidence: 99%

Muscle Mitochondrial Dysfunction in Horses Affected by Acute Laminitis

et al. 2014

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Laminitis is a common and debilitating disease affecting horses and ponies. It often leads to the demise of the animal. Energy deficiency is suspected to entrain the disruption of the hemidesmosomes leading to the failure of the dermal-epidermal interface. The aim of this study was to measure the muscle mitochondrial function by high resolution respirometry. Muscle micro-biopsies were obtained from 11 horses affected by acute metabolic laminitis, 6 horses affected by acute laminitis resulting from a systemic inflammation response syndrome and 28 healthy horses distributed in 2 control groups: 17 horses with a body condition score [BSC, ranging from 0 (emaciated) to 5 (obese)] of 2 to 3 and 11 horses with a BSC of 4 to 5. During the acute phase of laminitis, a significant reduction of the muscle mitochondrial respiration was observed. The muscle mitochondrial dysfunction occurred independently of the etiology (metabolic disorder or systemic inflammation) leading to laminitis. The reduction of the oxidative phosphorylation and of the maximal respiratory capacity (after uncoupling) may induce depletion of the cell's ATP content. If the same mitochondrial alteration occurs in the foot lamina, mitochondria targeting should be considered for the future, not only to better understand the physiopathology of the disease but also to maintain and to support the mitochondrial function before reaching the « mitochondrial dysfunction threshold » that may lead to the failure of the dermal-epidermal interface.

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Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle

Cited by 139 publications

References 48 publications

Heterogeneous effects of old age on human muscle oxidative capacity in vivo: a systematic review and meta-analysis

Heterogeneous effects of old age on human muscle oxidative capacity in vivo: a systematic review and meta-analysis

Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg

Muscle Mitochondrial Dysfunction in Horses Affected by Acute Laminitis

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