Oxidative stress and psychiatric morbidity in patients with facial acne

Awad, Sara M.; Morsy, Hanan; Sayed, Ayat A.; Mohamed, Nahed Thabet; Ezzat, Ghada M; Noaman, Mostafa M.

doi:10.1111/jocd.12366

Cited by 33 publications

(30 citation statements)

References 23 publications

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“…In oxidative stress, the balance between antioxidant defense mechanism and free radical formation is disturbed and endothelial dysfunction occurs 15 . Acne patients not only have local tissue damage but are also under systemic oxidative stress 16 . Recent studies have shown that oxidative stress is important in the progression of acne as well as the etiopathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

Akyürek

Kurtipek

Kurku

et al. 2020

J of Cosmetic Dermatology

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Background Acne vulgaris is a common skin disease in adolescents known to be associated with oxidative stress. However, the number of studies in which oxidative stress and antioxidants are evaluated together is limited. Aims In this study, we aimed to investigate L‐arginine/nitric oxide (NO) pathway metabolites, ischemia‐modified albumin (IMA), and vitamin A and E levels in patients with acne and its association with disease severity. Patients/Methods Ninety patients with acne and 30 healthy adults were included in the study. The serum levels ofL‐arjinin, L‐arginine metabolites, IMA, and vitamins A and E measured in the patient and control groups. Results Asymmetric dimethylarginine (ADMA), LNG‐monomethyl‐L‐arginine (L‐NMMA) and symmetric dimethylarginine (SDMA), and IMA levels were significantly higher in the patients with acne than in the control group (P ˂ .05). The L‐arginine/ADMA ratio and citrulline and vitamin A levels were significantly lower in patients with acne than those of the controls (P ˂ .05). ADMA and IMA plasma levels were increased in parallel with the disease severity (P ˂ .05). L‐arginine/ADMA ratio, L‐arginine, citrulline, and vitamin A plasma levels decreased as the disease became severe (P ˂ .05). Although L‐arginine and vitamin E levels were lower in the patient group compared to the control group, the difference was not statistically significant (P ˃ .05). Conclusion These results suggest that IMA and L‐arginine‐NO pathway associated with ischemia and oxidative stress may play an important role in the pathogenesis and progression of acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

Akyürek

Kurtipek

Kurku

et al. 2020

J of Cosmetic Dermatology

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“…While some authors found significant relationship between acne severity and quality of life; some of them did not report any significant relationship [10,[16][17][18][22][23][24][25][26]. The differences in the findings of various studies higlight the social, behavioral and cultural factors, differences in population characteristics and individual perception.…”

Section: Discussionmentioning

confidence: 99%

Akne vulgaris hastalarının değerlendirilmesi için hangi yaşam kalite ölçeği kullanılmalıdır? CADI ya da DYKİ? Bir prospektif çalışma

Tatlıparmak

Aksoy

Karadağ

2019

Archives of Clinical and Experimental Medicine

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Aim: Acne vulgaris is one of the most common diseases that affects quality of life. While the Dermatology Life Quality Index (DLQI) is the most frequently used life quality index for dermatologic disorders, the Cardiff Acne Disability Index (CADI) is an acne-spesific quality of life scale. The aim of this study was to determine which scale should be more appropriate and practical to evaluate the quality of life in acne patients and to compare the differences between two scales. Methods: Acne scores of 273 patients who were admitted to the dermatology outpatient clinic between December 2015 and November 2016 were determined by the Global Acne Grading System (GAGS) (range 0 to 44). The DLQI (range 0 to 30) and CADI scores (range 0 to 20) were calculated to evaluate the effect of patients' quality of life. Results: The mean GAGS score of the patients was 20.3, and the mean of CADI score was 6.1, while the mean of DLQI was 6.0. There was a significant positive correlation between total GAGS score and CADI and DLQI (r=0.639, p<0.001). When the relationship between the distribution of acne lesions and quality of life scales was evaluated; CADI score was significantly higher in the forehead localization group than in the non-forehead localization group (p=0.012), and the CADI and DLQI scores were higher in the upper back group than the group without back localization (p=0.001and p= 0.017 respectively). Conclusion: In our study, it was observed that the DLQI and CADI scales were not superior to each other in evaluating the quality of life in patients with acne. Besides, we think that the effect of quality of life on facial acne cases can be determined more clearly with CADI scale.

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“…In the other hand Kouotou et al in Cameroon [13] showed that the severity of acne influences the occurrence of anxiety since they found a positive correlation between the ECLA and GAD-7 scores. Awad et al in Egypt [22], Lukaviciute et al in Lithuania [19],Gül et al [17] and Öztürk et al in Turkey [7] also found positive correlation between severity of acne and anxiety, hence the importance of taking in charge patient on psychological plan no matter the severity of their acne.…”

Section: Discussionmentioning

confidence: 99%

Acne and psychiatric comorbidities in Lomé (Togo): case-control study

Saka

Teclessou

Akakpo

et al. 2019

Preprint

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Objectif The aim of this study was to investigate psychiatric comorbidities (depression and anxiety) associated with acne in dermatology in Lomé (Togo). Material and methods We conducted a casecontrol study between July 2017 and February 2018. Each case was matched to two controls by sex and age (± 5 years). The ECLA grid was used for the clinical evaluation of acne, and the GAD-7 and PHQ-9 questionnaires were used for respective screening of anxiety and depression. Results We recruited, with their consent, 900 subjects including 300 patients and 600 matched to two controls according to sex and age (± 5 years). The mean age of the cases was 23.7±5.7 years and that of the controls was 23.6 ± 6.2 years, with no difference between the two groups (p = 0.9362). The overall severity score for acne according to the ECLA grid ranged from 2 to 28 points. The severity of acne was not correlated with anxiety scores (GAD-7: r = -0.02; p = 0.6724) and depression (PHQ-9: r = 0.11; p = 0.0567). The GAD-7 questionnaire allowed us to note 72 cases of anxiety (24%) among our patients and 37 cases among our controls (6.2%). The mean GAD-7 score in the cases was 6.5±4.9 compared with 2.9±3.8 in the controls (p <0.0001). Similarly, the PHQ-9 questionnaire allowed us to detect 92 cases of depression (30.7%) among our patients and 82 cases of depression among our controls (13.7%). The average of the PHQ 9 score in the cases was 7.2 ± 5.2 versus 4.0 ± 4.7 in the controls (p <0.0001). Conclusion: Depression and anxiety are significantly associated with acne, regardless of severity. It is important to look for them in any patient admitted for acne, for a psychological / psychiatric decision. PHQ-9: Health Questionnaire-9

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Oxidative stress and psychiatric morbidity in patients with facial acne

Abstract: Our results indicate that the high levels of anxiety and depression in patients with facial acne were not related to oxidative stress. Anxiety was more common than depression and was directly related to QoL impairment.

Cited by 33 publications

References 23 publications

Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

Akne vulgaris hastalarının değerlendirilmesi için hangi yaşam kalite ölçeği kullanılmalıdır? CADI ya da DYKİ? Bir prospektif çalışma

Acne and psychiatric comorbidities in Lomé (Togo): case-control study

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