Oxidative stress and related factors in patients with ankylosing spondylitis

Abstract

Objective: Ankylosing spondylitis (AS) is a chronic inflammatory disease of the spine and sacroiliac joints of unknown etiology.Recent studies have reported increased oxidative stress, which is implicated in the pathogenesis of a number of diseases, in AS. The purpose of this study was to investigate oxidative stress and related factors in AS.Material and Methods: Eighty-five patients with years; 65 male/20 female] and 56 healthy subjects [36 (21-63) years; 39 male/17 female] with no known cardiovascular risk factors were enrolled. Serum total oxidant status (TOS) and total anti-oxidant status (TAS) were studied. The Bath ankylosing spondylitis functional index (BASFI), Bath ankylosing spondylitis disease activity index (BASDAI), and Bath ankylosing spondylitis metrology index (BASMI) were calculated. A logistic regression model was used to identify the independent risk factors for TOS.Results: No differences were observed in terms of demographic characteristics, laboratory findings, or TAS concentrations between the patient and control groups. However, the serum TOS levels were significantly higher in the AS group than in the controls (p=0.003). The comparison of cases of active (BASDAI ≥4) and inactive AS revealed significantly higher TOS levels in the active disease group. The TOS and TAS concentrations did not differ between patients treated with biological agents and those treated with conventional agents. Correlation analysis yielded significant correlations between TOS and TAS, BASMI, BASFI, BASDAI, erythrocyte sedimentation rate (ESR), and high-sensitive C-reactive protein (hs-CRP) (p<0.05; r values ranged from 0.291 to 0.452) and a positive correlation between TAS and BASMI (p<0.05; r=0.344). Based on regression analysis, BASDAI, BASMI, and hs-CRP independently predicted the TOS levels [p<0.05, R²: 0.262, and standard error of the estimate (SEE): 10.96] Conclusion: Oxidative stress levels were higher in patients with AS than in healthy subjects. Patients with active disease status had significantly higher oxidative stress than patients with inactive disease status and healthy controls. Treatment status has no effect on TOS, and BASMI, BASDAI, and hs-CRP are independent variables associated with TOS. The TAS levels were found to be associated with only BASMI.

The Effect of Whole‐Body Cryotherapy at Different Temperatures on Proinflammatory Cytokines, Oxidative Stress Parameters, and Disease Activity in Patients with Ankylosing Spondylitis

“…Among all patients in the study entry, we observed significant positive correlation between IL-8 and the TBARS concentration. In our opinion, this correlation briefly describes and corresponds with the patient's condition before therapy and may suggest that disease-related factors are involved in the increased oxidative stress in AS, as suggested previously by Solmaz and Kozaci [ 16 ].…”

“…The increased production of proinflammatory cytokines generally accompanies increased levels of oxidative stress markers [ 5 ]. Recent studies have reported an increase in oxidative stress in AS [ 15 , 16 ]. AS increases oxidant processes and decreases antioxidant capacity of the system; however, the association of AS with oxidative stress markers and cytokines remains uncertain [ 5 , 16 , 17 ].…”

Modulation of inflammatory response and gut microbiota in ankylosing spondylitis mouse model by bioactive peptide IQW

“…A broad range of oxidation products are generated by the reaction of oxygen with unsaturated lipids (lipid peroxidation), with MDA being possibly the most mutagenic reaction product (Ayala et al ; Ying et al ; Yin et al ). Studies have found increased MDA concentrations in blood samples from symptomatic AS patients relative to the CTRL (Kozaci et al ; Solmaz et al ). The important antioxidant enzymes SOD, CAT and GSH‐PX are central in preventing damage by reducing the toxic nature of free radicals due to their capacity to scavenge superoxide radicals within cells (Kozaci et al ; Li et al ).…”

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

“…As seronegative spondyloarthritis (SpAS) affects predominantly the spine and the sacroiliac joints as well as the peripheral joints, especially the lower limbs [1][2][3] . The well-being of patients is greatly affected as a result of the severe damage caused by the disease in the mobility of vertebral column, resulting in physical disability 4 .…”