Oxidative stress biomarkers in long-term participants in clean-up work after the Hebei Spirit oil spill

Noh, Su Ryeon; Cheong, Hae-Kwan; Ha, Mina; Eom, Sang‐Yong; Kim, Heon; Choi, Young-Hyun; Paek, Domyung

doi:10.1016/j.scitotenv.2015.02.039

Cited by 52 publications

(22 citation statements)

References 48 publications

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“…PAHs are known to be potent oxidant stressors (9), which can contribute to inflammation and chronic disease pathogenesis. These effects of PAHs have been observed in epidemiological studies, including studies of occupationally-exposed adults found to have higher levels of oxidative stress biomarkers and lipid peroxidation (10-12). Studies among adult NHANES participants found that urinary PAH levels were positively associated with serum markers of inflammation and oxidative stress, including C-reactive protein (CRP) and gamma glutamyl transferase (GGT) (3,13-15).…”

Section: Introductionmentioning

confidence: 84%

Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003–2008

Farzan

Chen

Trachtman

et al. 2016

Environmental Research

103

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Objective Recent evidence has suggested that polycyclic aromatic hydrocarbons (PAHs) may contribute to cardiometabolic and kidney dysfunction by increasing oxidative stress, but little is known about impacts in childhood. Study design We performed cross-sectional analyses of 660 adolescents aged 12–19 years in the 2003–2008 National Health and Nutrition Examination Survey (NHANES), using levels of 10 monohydroxylated urinary PAH metabolites as our exposure. Our primary outcomes of interest were biomarkers of oxidative stress and renal function, including estimated glomerular filtration rate (eGFR), urinary albumin to creatinine ratio (ACR), insulin resistance, and serum uric acid, gamma glutamyl transferase (GGT) and C-reactive protein (CRP). Results We observed statistically significant associations between PAH metabolites and levels of serum GGT, CRP, uric acid and eGFR. Each 100% increase in 2-hydroxyphenanthrene was related to a 3.36% increase in uric acid (95% CI: 0.338–6.372; p=0.032), a 3.86% increase in GGT (95% CI: 1.361–6.362; p=0.005) and a 16.78% increase in CRP (95% CI: 1.848–31.689; p=0.029). Each 100% increase in 4-hydroxyphenanthrene was associated with a 6.18% increase in GGT (95% CI: 4.064–8.301; p<0.001) and a 13.66% increase in CRP (95% CI: 2.764– 24.564; p=0.017) Each 100% increase in 9-hydroxyfluorene was associated with a 2.58% increase in GGT (95% CI: 0.389–4776; p=0.024). Each 100% increase in 3-hydroxyphenanthrene was associated with a 2.66% decrease in eGFR (95% CI: -4.979–-0.331; p=0.028). Conclusions Urinary PAH metabolites were associated with serum uric acid, GGT and CRP, suggesting possible impacts on cardiometabolic and kidney function in adolescents. Prospective work is needed to investigate the potential long-term health consequences of these findings.

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Section: Introductionmentioning

confidence: 84%

Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003–2008

Farzan

Chen

Trachtman

et al. 2016

Environmental Research

103

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“…PHE is often used as a model for the study on PAHs metabolism, it is readily bioavailable (Hannam et al, 2010a;Wootton et al, 2003) and the smallest PAH to have a bay and a K-region that represent a highly reactive region where the main carcinogenic species can be formed (Zhang et al, 2014). Owing to its high lipophilic nature, PHE can easily penetrate biological membranes; bioaccumulation tends to be fast and, as a global persistent organic pollutant, it may raise health concerns even several decades after exposure (Jin et al, 2015;Noh et al, 2015;Xiu et al, 2015). PHE has been included in "Priority Pollutants" list by the United States Environment Protection Agency (US, EPA), and although not carcinogenic and mutagenic, it has been shown to be toxic to several marine animals (Zhang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…PAH biotransformation can lead to the production of reactive oxygen species (ROS), which may oxidizes proteins, DNA and cause lipid peroxidation (Grintzalis et al, 2012;Noh et al, 2015). Consequently, a complex array of antioxidant systems acts preventing cumulative oxidative damage by neutralizing excess of ROS (Halliwell and Gutteridge, 1985).…”

Section: Introductionmentioning

confidence: 99%

Exposure to phenanthrene and depuration: Changes on gene transcription, enzymatic activity and lipid peroxidation in gill of scallops Nodipecten nodosus

et al. 2016

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Understanding the mechanism of phenanthrene (PHE) biotransformation and related cellular responses in bivalves can be an important tool to elucidate the risks of polycyclic aromatic hydrocarbons (PAHs) to aquatic organisms. In the present study it was analyzed the transcriptional levels of 13 biotransformation genes related to cytochrome P450 (CYP), glutathione S-transferase (GST), sulfotransferase (SULT), flavin-containing monooxygenase and fatty acid-binding proteins by qPCR in gill of scallops Nodipecten nodosus exposed for 24 or 96h to 50 or 200μgL(-1) PHE (equivalent to 0.28 and 1.12μM, respectively), followed by depuration in clean water for 96h (DEP). Likewise, it was quantified the activity of catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione reductase (GR), glucose 6-phosphate dehydrogenase (G6PDH), GST and levels of lipid peroxidation. Increased transcriptional levels of CYP2UI-like, CYP2D20-like, CYP3A11-like, GSTomega-like, SULT1B1-like genes were detected in organisms exposed to PHE for 24 or 96h. In parallel, GR and GPX activities increased after 96h exposure to 200μgL(-1) PHE and G6PDH activity increased after 24h exposure to 50μgL(-1) PHE. This enhancement of antioxidant and phase I and II biotransformation systems may be related to the 2.7 and 12.5 fold increases in PHE bioaccumulation after 96h exposure to 50 and 200μgL(-1) PHE, respectively. Interestingly, DEP caused reestablishment of GPX and GR activity, as well as to the transcript levels of all upregulated biotransformation genes (except for SULT1B1-like). Bioaccumulated PHE levels decreased 2.5-2.9 fold after depuration, although some biochemical and molecular modifications were still present. Lipid peroxidation levels remained lower in animals exposed to 200μgL(-1) PHE for 24h and DEP. These data indicate that N. nodosus is able to induce an antioxidant and biotransformation-related response to PHE exposure, counteracting its toxicity, and DEP can be an effective protocol for bivalve depuration after PHE exposure.

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“…Second, there were eight environmental impact projects on marine oil spill in China from 2001 to 2012, which were more than the socio-economic impact projects (two projects) and the human health impact projects. Human health is more likely to be seriously impacted by large chemical spills in or close to urban areas than by oil spill (Noh et al, 2015). A major oil spill event can exert long-term effects on the socio-economic development in a region, therefore, a holistic assessment that includes the impacts of oil spill on environment, socio-economy and human health is necessary and essential.…”

Section: Randd Projectsmentioning

confidence: 99%

The management in response to marine oil spill from ships in China: A systematic review

Xiong

Long

Tang

et al. 2015

Marine Pollution Bulletin

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Oxidative stress biomarkers in long-term participants in clean-up work after the Hebei Spirit oil spill

Cited by 52 publications

References 48 publications

Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003–2008

Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003–2008

Exposure to phenanthrene and depuration: Changes on gene transcription, enzymatic activity and lipid peroxidation in gill of scallops Nodipecten nodosus

The management in response to marine oil spill from ships in China: A systematic review

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