Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis

Kruk, Joanna; Aboul‐Enein, Hassan Y.; Kładna, Aleksandra; Bowser, J.E.

doi:10.1080/10715762.2019.1612059

Cited by 195 publications

(160 citation statements)

References 211 publications

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“…Ibuprofen, a commonly used anti-inflammatory drug, is recommended for the long-term treatment of airway inflammation in cystic fibrosis lung disease (Flume, O'Sullivan, Robinson, Goss, Mogayzel, Willey-Courand, Bujan, Finder, Lester, Quittell, Rosenblatt, Vender, Hazle, Sabadosa, Hernandes, Xu & Griendling, 2018). When the balance is broken by inflammatory factors, the body will produce an oxidative stress response, leading to cell oxidative damage and development of multi-system diseases (Kruk, Aboul-Enein, Kladna & Bowser, 2019;Sies, 2015). Oxidative stress in turn activates multiple signaling pathways to induce inflammation, such as activation of NF-κB and NOD-like receptor protein 3 (NLRP3), further promoting the maturation of pro-inflammatory factors (Ahmad & Ahsan, 2020).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

Cao

et al. 2020

Carbohydrate Polymers

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Highlights: COVID-19 has become a Public Health Emergency of International Concern (PHEIC) and a worldwide pandemic  The Lung Cleansing and Detoxifying Decoction has shown definite therapeutic effects on COVID-19 patients  Bioactive polysaccharides in the decoction appear to involve immunomodulatory activity, antiinflammatory activity, anti-oxidative activity and regulation of gut microbiota balance  Producing COVID-19 vaccines with polysaccharides as the adjuvants is an innovative strategy Abstract J o u r n a l P r e -p r o o f 2The new coronavirus pneumonia, named COVID-19 by the World Health Organization, has become a pandemic. It is highly pathogenic and reproduces quickly. There are currently no specific drugs to prevent the reproduction and spread of COVID-19. Some traditional Chinese medicines, especially the Lung Cleansing and Detoxifying Decoction (Qing Fei Pai Du Tang), have shown therapeutic effects on mild and ordinary COVID-19 patients. Polysaccharides are important ingredients in this decoction. This review summarizes the potential pharmacological activities of polysaccharides isolated by hot water extraction from Lung Cleansing and Detoxifying Decoction, which is consistent with its production method, to provide the theoretical basis for ongoing research on its application.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

Cao

et al. 2020

Carbohydrate Polymers

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“…It has been reported to have an excellent inhibitory effect on high temperature and pressure-resistant bacterial spores [10] in addition to its promising effect against large categories of bacterial strains [11]. As per documented reports, zinc ions can inhibit proliferative and metastatic cancer cells by interacting with altered cell metabolism [12]. Cellular abnormalities or even cell death is a normal consequence resulting from disruption of redox (reduction-oxidation) balance in a cancer cell [13].…”

Section: Introductionmentioning

confidence: 93%

“…The degree of damage to the bacterial cells, post-treatment, by the green synthesized ZnONPs was analysed by SEM. Samples subjected to SEM study were prepared following overnight incubation of both the treated and control bacterial cells at 37°C [12]. Centrifugation (4 min, 4000 rpm) of 1 ml of these incubated cultures (both control and treated) was performed to obtain the pellet.…”

Section: Study Of Bacterial Cells By Sem (Scanning Electron Microscope)mentioning

confidence: 99%

Green cardamom mediated phytosynthesis of ZnONPs and validation of its antibacterial and anticancerous potential

Pal

Mukherjee

et al. 2020

Mater. Res. Express

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Different conventional methods for synthesizing zinc oxide nano-particles (ZnONPs) significantly involves physical and chemical routes. But, often these synthesis processes are quite expensive and also involve the profuse use of many hazardous reagents. To overcome these problems, we have employed a convenient single step phytochemical synthesis of ZnONPs by using abundantly available bioresource, green cardamom. Aqueous extract of green cardamom served the purpose of reducing agent in the formation of ZnONPs, as the extract contains a high amount of flavonoids which hold great reducing properties. Various characterization analyses such as XRD, UV-vis, FTIR, SEM has been done to confirm the formation of ZnONPs and their size and shape. Antibacterial activity of the green ZnONPs was identified against Gram-positive as well as Gram-negative bacterial strains. Significant growth inhibition was found against all. The further anti-cancerous potential of synthesized nanoparticles was also studied on hepatocellular cell lines showing its potential to be a trustworthy anti-cancerous agent.

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“…Extensive scientific studies have shown that oxidative stress is involved in several acute and chronic diseases including cancer. 1,2 Elevated levels of Reactive Oxygen Species (ROS) causes overproduction of malondialdehyde (MDA), a final product of polyunsaturated fatty acids peroxidation in the cells. Hence, MDA is commonly considered as one of the key markers of oxidative stress and antioxidant status in cancerous patients.…”

Section: Introductionmentioning

confidence: 99%

“…3 Increased levels of ROS and cell damage is linked with the pathogenesis of cancer. 1 Antioxidants are substances that may protect tissues and organs from the damage caused by free radicals. Antioxidants neutralize free radicals by donating one of their own electrons and ending the electron ''stealing" reaction.…”

Section: Introductionmentioning

confidence: 99%

Antioxidants with Multivitamin and Mineral Supplementation Attenuates Chemotherapy or Radiotherapy-induced Oxidative Stress in Cancer Patients

Patil¹,

More²

2020

IJPER

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Aim:The present study was planned to evaluate the combined effects of antioxidant multivitamin and minerals (AMM) in reducing cancer and cancer therapy-induced oxidative stress. In addition cell viability of human malignant melanoma and normal mouse fibroblast cell lines after treatment with different concentrations of AMM and methotrexate were also estimated. Methods: Amongst the 120 cancer patients recruited for the study, 60 patients each were treated with radiotherapy and chemotherapy. In both radiotherapy and chemotherapy, 30 patients each were supplemented with AMM for 30 days. Thirty healthy human volunteers were recruited for comparison. On day 31, blood samples were collected for estimation of oxidative stress markers (MDA and nitrite), endogenous (SOD and GPx) and exogenous (Vitamin C and Vitamin E) antioxidants and essential trace elements (zinc, copper and selenium). In addition, cell viability of human malignant melanoma and normal mouse fibroblast cell lines were estimated after treatment with different concentrations of AMM and methotrexate. Results: Supplementation of AMM during cancer therapy minimized the burden of free reactive radicals and restored the endogenous and exogenous antioxidants and essential trace element levels. In addition, AMM has no cytotoxic effect on normal mouse fibroblast cell lines. But AMM imparts suppression of cell proliferation in human malignant melanoma. Conclusion: Supplementation of antioxidants with multivitamin and mineral during cancer therapy is found to be beneficial as they minimize the burden of free reactive radicals and restores the endogenous and exogenous antioxidants and essential trace element levels.

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Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis

Cited by 195 publications

References 211 publications

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

Green cardamom mediated phytosynthesis of ZnONPs and validation of its antibacterial and anticancerous potential

Antioxidants with Multivitamin and Mineral Supplementation Attenuates Chemotherapy or Radiotherapy-induced Oxidative Stress in Cancer Patients

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