Oxidative stress in childhood steroid sensitive nephrotic syndrome and its correlation with DNA damage

Reddy, Priyanka; Sindgikar, Seema Pavaman; Shenoy, Rajgopal; Shenoy, Vijaya

doi:10.18203/2349-3291.ijcp20161853

Cited by 5 publications

(8 citation statements)

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“…This could be clarified via additional research. As reported by Reddy et al [37], in the present study, there was a significant increase in the antioxidant level when the pediatric NS were in remission; however, there remained a significant difference in the native thiol level and the disulphide/native thiol ratio between NS patients in remission and the controls. In contrast to the present findings, Karthikeyan et al [24] observed that there was not a difference in the plasma protein thiol level between controls and pediatric NS patients in remission after 8 weeks of prednisone therapy; the difference between the 2 studies might be due to differences is study design.…”

Section: Discussionsupporting

confidence: 70%

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Yazılıtaş

Öztek-Celebi

Erel

et al. 2019

Nephron

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Background: There is a growing body of evidence showing that there is an association between oxidative damage and kidney injury in patients with nephrotic syndrome (NS). Dynamic thiol/disulphide homeostasis (DTDH) is an important antioxidant system. The aim of this study was to determine if DTDH could be used as a biomarker of antioxidant status in pediatric NS patients using a novel automated method. Methods: The study included 39 patients with NS and 40 healthy controls. The DTDH level was measured using a calorimetric and automated method developed by Erel and Neselioglu. In the NS group, DTDH was measured during first-attack episode, relapse, and remission. Results: The native thiol, total thiol, and disulphide levels were significantly lower, the native thiol/total thiol ratio was significantly lower, and the disulphide/native thiol and disulphide/total thiol ratios were significantly higher in the NS patients during relapse and first-attack episode than during remission and in the controls. In addition, the native thiol and total thiol levels, and the native thiol/total thiol ratio were significantly lower, and the disulphide/native thiol and disulphide/total thiol ratios were significantly higher in the NS group during remission than those in the control group. Conclusions: The present findings show that DTDH shifted toward disulphide formation in the NS patients, even during remission. A clearer understanding of the mechanism of this disruption to homeostasis in NS patients might lead to the development of novel therapeutic strategies.

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Section: Discussionsupporting

confidence: 70%

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Yazılıtaş

Öztek-Celebi

Erel

et al. 2019

Nephron

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“…Our antioxidant and oxidant status results were well supported by a study done by the reddy's group in 2016. They found a significantly increased level of MDA and decreased the level of SOD activity and GSH in NS patients [8]. In contrast, another study found unaltered GSH concentrations and increased SOD concentration in children with NS [6,17].…”

Section: Discussionmentioning

confidence: 93%

“…The finding that reactive oxygen species (ROS) can act as mediators of glomerular injury advances our understanding of the disease's etiology significantly [7]. NS has also been related to increased oxidative stress in numerous studies [8,9]. MDA (Malondialdehyde), GSH (Glutathione), and SOD (Superoxide Dismutase) are all readily quantifiable markers of oxidative stress [8].…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Serum Albumin and Creatinine With Oxidative Stress Markers in Patients Having Nephrotic Syndrome

Parmar¹,

Mistry²,

Gang

2021

Int J Pharm Pharm Sci

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Objective: Children with nephrotic syndrome (NS) have a stressful condition, and oxidative damage may impair their treatment response. This study aims to gain a better understanding of the relationship between oxidative stress and NS to lay the basis for further research into improved diagnostic options, treatment, and prevention of the disease. Methods: We took a blood sample from 100 Indian patients aged 2-14 y. Each patient was tested for oxidative stress. The buege method was used to assess MDA levels in patients. The pyrogallol method was used to measure SOD activity in blood serum, and the jollow method was used to measure glutathione levels. Results: The levels of oxidative stress markers (MDA, SOD, and GSH) were compared between NS patients and the control. SOD and GSH concentrations were significantly decreased in the NS group when compared to the control. In contrast, MDA level was significantly higher in the NS group than in the control. In the correlation analysis, we found that the serum SOD activity was significantly positively correlated with serum albumin and creatinine level in patients with NS. Thus, oxidative stress in children with NS is indicated by reduced antioxidant potential because of low albumin. Therefore, it is thought that oxidative stress is implicated in the development of NS in Indian children. Conclusion: We concluded that oxidative stress was intensified in children with NS due to decreased antioxidant levels caused by hypoalbuminemia.

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“…Several studies have emphasized the pathophysiological importance of oxidative stress in patients with nephrotic syndrome and its influence on the response of these patients to therapy [ 29 – 31 ]. Antioxidants can neutralize the negative effects of free radicals and reactive oxygen species (ROS) and reduce the effects of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Selected salivary parameters in children with idiopathic nephrotic syndrome: a preliminary study

et al. 2021

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Background Disturbances in the levels of serum constituents occurring in chronic renal diseases can be reflected in the saliva composition. The aim of this study was to assess some selected salivary components in children suffering from idiopathic steroid-sensitive nephrotic syndrome (iNS). Methods A case–control study was performed on iNS and healthy participants. In unstimulated mixed saliva, pH, buffer capacity, total protein, α-amylase, peroxidase, calcium, magnesium, inorganic phosphate, fluoride, urea, uric acid and salivary flow rate were measured. Oral condition was assessed using dmft, DMFT, API and GI indices, usage of fluoride specimens and frequency of tooth brushing. Statistical analysis was performed by Shapiro–Wilk, Brown-Forsythe, Student’s t, ANOVA, Tukey’s and Pearson’s chi-square tests, Pearson’s and Spearman’s correlations, logistic regression and receiver operating characteristic (ROC) curve analysis. Results The study involved 94 participants of both genders aged 4–17 (47 cases in relapse or remission phase of iNS and 47 controls) who were treated in the clinic of pediatric nephrology or outpatient dental clinic. Neither group differed in the number of caries-affected primary and permanent teeth, gingival condition or use of fluoride specimens. The iNS group presented lower levels of magnesium (0.41 ± 0.34 vs. 0.60 ± 0.38 mg/dL, P < 0.05) and fluoride (0.15 ± 0.10 vs. 0.21 ± 0.10 ppm, P < 0.01) and higher contents of urea (35.19 ± 15.55 vs. 25.21 ± 10.78 mg/dL, P < 0.01) and uric acid (2.90 ± 1.23 vs. 2.34 ± 1.04 mg/dL, P < 0.05) than the controls. In the iNS participants with relapse, a higher peroxidase activity and lower magnesium content than in the remission phase were found. ROC analysis showed a weak discriminatory power of these salivary constituents for the differentiation of participants with and without disease (accuracy from 66.0 to 67.0%, area under the ROC curve (AUC) from 0.638 to 0.682) and the relapse and remission phases (accuracy 70.2% and 68.1% and AUC 0.717 and 0.675, respectively). Conclusions Levels of urea, uric acid, magnesium and fluoride in saliva can be associated with the course of iNS. Salivary levels of peroxidase and magnesium can be related to the phase of the disease. However, the measurements of these parameters cannot be useful as a noninvasive tool in diagnosing iNS and the phase of the disease.

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Oxidative stress in childhood steroid sensitive nephrotic syndrome and its correlation with DNA damage

Cited by 5 publications

References 0 publications

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Correlation of Serum Albumin and Creatinine With Oxidative Stress Markers in Patients Having Nephrotic Syndrome

Selected salivary parameters in children with idiopathic nephrotic syndrome: a preliminary study

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