Oxidative stress in environmental-induced carcinogenesis

Mena, Salvador; Ortega, Ángel; Estrela, José M.

doi:10.1016/j.mrgentox.2008.09.017

Cited by 309 publications

(230 citation statements)

References 132 publications

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“…[109][110][111][112] The indirect mechanism of UV-induced damage involves oxidative stress caused by an imbalance between ROS production and ability of cells to scavenge the reactive intermediates involves ROS production which in turn induces DSBs. 61,113 Anti-cancer drugs such as DNA replication inhibitors, crosslinking agents and topoisomerase inhibitors are capable of inducing DSBs, which subsequently lead to gH2AX formation because of replication and transcriptional stresses. DNA replication inhibitors, such as hydroxyurea, inhibit DNA replication by affecting deoxynucleotide pools, causing stress at stalled replication forks, which induces DNA damage.…”

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confidence: 99%

γH2AX: a sensitive molecular marker of DNA damage and repair

2010

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Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming cH2AX, is an early cellular response to the induction of DNA double-strand breaks. Detection of this phosphorylation event has emerged as a highly specific and sensitive molecular marker for monitoring DNA damage initiation and resolution. Further, analysis of cH2AX foci has numerous other applications including, but not limited to, cancer and aging research. Quantitation of cH2AX foci has also been applied as a useful tool for the evaluation of the efficacy of various developmental drugs, particularly, radiation modifying compounds. This review focuses on the current status of cH2AX as a marker of DNA damage and repair in the context of ionizing radiation. Although the emphasis is on c-radiationinduced cH2AX foci, the effects of other genotoxic insults including exposure to ultraviolet rays, oxidative stress and chemical agents are also discussed.

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confidence: 99%

γH2AX: a sensitive molecular marker of DNA damage and repair

2010

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“…Extracts from H. fusiformis showed excellent ability to scavenge free radicals in prior published work, and our results support this antioxidant effect. It is had been reported that ROS eventually cause DNA damage, which plays a role in the development of carcinogenesis, whereby insufficient cellular repair mechanisms may contribute to premature aging and apoptosis (Mena et al, 2009). In the present study, both A+M and MeOH extracts were more effective that the fractions (n-hexane, 85% aqueous MeOH, n-BuOH and water) in reducing cellular ROS.…”

Section: Resultsmentioning

confidence: 99%

Effect of Hizikia fusiformis extracts on reactive oxygen species mediated oxidative damage

Baek¹,

Lim²

2017

Int. J. Adv. Res. Biol. Sci

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We investigated the effect of Hizikia fusiformis extracts on the production of cellular reactive oxygen species (ROS) in human fibroblast cell line HT-1080to evaluate their antioxidant activities. The H 2 O 2 -induced ROS generation was measured using a dichlorofluorescein-diacetate (DCFH-DA) assay. The acetone+methylene chloride (A+M)and methanol (MeOH) extracts dosedependently decreased the level of ROS production induced by H 2 O 2 in comparison with the levels observed in the control without the extracts. Treatments with A+M and MeOH extracts for 120 min reduced ROS generation by 86% and 77%, respectively. All tested fractions decreased ROS production in a concentration-dependent manner. Treatments with n-hexane,85% aqueous MeOH and n-butanol (BuOH) fractions resulted in54%, 54% and 31% ROS inhibition, respectively. These results indicate that both A+M and MeOH extracts of H. fusiformis had a stronger effect in reducing ROS production. This present preliminary study suggests that extracts from H. fusiformis have nutraceutical value with potent antioxidant activity that alleviates radical-induced damage.

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“…Oxidative stress is the imbalance between ROS production and a biological system's ability to detoxify these reactive intermediates. The oxidative stress is considered as a critical pathophysiological mechanism in cancererogenesis [53]. Reactive chemical species can reach DNA by diffusion and the resultant bimolecular reaction will damage the DNA [54].…”

Section: Pollution and Its Effect On The Skinmentioning

confidence: 99%

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Sawant¹

2018

Cosmetics

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Abstract:Pollution from air and sunlight has adverse effects on human health, particularly skin health. It creates oxidative stress, which results in skin diseases, including skin cancer and aging. Different types of antioxidants are used as preventative actives in skin-care products. However, they have some limitations as they also scavenge oxygen. Recently, spin traps are being explored to trap free radicals before these radicals generating more free radicals (cascading effect) and not the oxygen molecules. However, not all spin traps can be used in the topical cosmetic skin-care products due to their toxicity and regulatory issues. The present review focuses on the different pathways of reactive oxygen species (ROS) generation due to pollution and the potential use of spin traps in anti-pollution cosmetics to control ROS.

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Oxidative stress in environmental-induced carcinogenesis

Cited by 309 publications

References 132 publications

γH2AX: a sensitive molecular marker of DNA damage and repair

γH2AX: a sensitive molecular marker of DNA damage and repair

Effect of Hizikia fusiformis extracts on reactive oxygen species mediated oxidative damage

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

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