Oxidative stress induction in woodworkers occupationally exposed to wood dust and formaldehyde

Abstract

Background Many workers are exposed to wood dust (WD) and formaldehyde (FA), whose carcinogenic activity is supposed to be oxidative stress-mediated. This study aims to assess to what extent the occupational exposure to WD and FA, albeit within regulatory limits, could result in OS induction in a woodworkers’ population. Methods The sample population consisted of 127 woodworkers from 4 factories and 111 unexposed controls. Individual exposure was assessed by personal air-samplers. Each participant enrolled in the study filled out a questionnaire and provided a urinary sample to quantify OS biomarkers, namely 15-F2t-IsoProstane (15-F2t-IsoP) and 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo). The main confounding factor for OS, i.e. tobacco smoking exposure, was assessed by measuring cotinine in urine samples. Results Woodworkers were exposed to significantly higher amounts of WD and FA as compared to controls (p < 0.001). Among OS biomarkers, 15-F2t-IsoP showed statistically significant higher values in woodworkers compared to controls (p = 0.004). A significant, positive correlation was observed between 15-F2t-IsoP and 8-oxo-dGuo (p = 0.005), cotinine (p = 0.05), FA (p < 0.001) and WD (p = 0.01); 8-oxo-dGuo was significantly correlated with cotinine (p = 0.001) and WD (p = 0.004). In addition, WD and FA were significantly correlated each other (p < 0.001). Conclusions The study confirms that WD and FA may induce OS in woodworkers, and highlights that even the compliance with occupational exposure limits can result in measurable biological outcomes.

Formaldehyde in Hospitals Induces Oxidative Stress: The Role of GSTT1 and GSTM1 Polymorphisms

“…Given the high variability in FA exposure according to the different tasks of the subjects enrolled, the individual exposure was quantified, for each subject, using a radial symmetry diffusive sampler (Radiello ® , ICS Maugeri SpA, Pavia, Italy) (https://radiello. com/, accessed on 8 June 2021), as described in previous studies [47,48]. The sampler was clipped near the volunteers' breathing zone during a whole working shift, in order to assess the FA concentration in the air inhaled by each worker.…”

Simple and fast microderivatization method for determining formaldehyde using narrow-bore liquid chromatography with UV detection

“…17,18 This cell and tissue damage may be due to the reactive oxygen species induced by formaldehyde, which result in oxidative stress. [19][20][21] Formaldehyde is ubiquitous in daily life and plays a pivotal role in coating materials, binders, resins, chemicals, textiles, anti-corrosion materials, and cosmetics. [22][23][24] In addition, it acts as a preservative in many household and personal care products.…”

Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden

“…Wood dust exposure is associated with different exposure scenarios and compounds depending on the industry sector, tasks and wood preservatives (e.g. formaldehyde, chromium, organochlorine compounds) (Ghelli et al 2021 ; Vallières et al 2015 ). Exposure to wood dust as well and formaldehyde have been shown to induce oxidative stress in occupationally exposed subjects even at levels below current occupational exposure limits (Ghelli et al 2021 ).…”

“…formaldehyde, chromium, organochlorine compounds) (Ghelli et al 2021 ; Vallières et al 2015 ). Exposure to wood dust as well and formaldehyde have been shown to induce oxidative stress in occupationally exposed subjects even at levels below current occupational exposure limits (Ghelli et al 2021 ). In experimental studies, several of these compounds have shown to induce oxidative stress in testicular tissue and germ cells (Duong et al 2011 ; Pereira et al 2021 ; Sujatha et al 2001 ).…”