Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study

Abstract

Previous evidence supports the important role that oxidative stress (OxS) plays in metabolic syndrome (MetS)-related manifestations. We determined the relationship between the number of MetS components and the degree of OxS in MetS patients. In this comparative cross-sectional study from the LIPGENE cohort, a total of 91 MetS patients (43 men and 48 women; aged between 45 and 68 years) were divided into four groups based on the number of MetS components: subjects with 2, 3, 4 and 5 MetS components (n=20, 31, 28 and 12, respectively). We measured ischemic reactive hyperemia (IRH), plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), total nitrite, lipid peroxidation products (LPO), hydrogen peroxide (H2O2), superoxide dismutase (SOD) and glutathione peroxidase (GPx) plasma activities. sVCAM-1, H2O2 and LPO levels were lower in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. IRH and total nitrite levels were higher in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. SOD and GPx activities were lower in subjects with 2 MetS components than subjects with 4 or 5 MetS components. Waist circumference, weight, age, homeostatic model assessment-β, triglycerides (TGs), high-density lipoprotein and sVCAM-1 levels were significantly correlated with SOD activity. MetS subjects with more MetS components may have a higher OxS level. Furthermore, association between SOD activity and MetS components may indicate that this variable could be the most relevant OxS biomarker in patients suffering from MetS and could be used as a predictive tool to determine the degree of the underlying OxS in MetS.

Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study

“…Furthermore, systemic OxS is increased in subjects with MetS and is strongly associated with visceral fat accumulation (Fujita et al 2006;Yubero-Serrano et al 2013). In our study, we found that TG levels were higher and HOMAβ was lower in those people with shorter telomeres and increased OxS levels.…”

Advanced oxidation protein products are more related to metabolic syndrome components than biomarkers of lipid peroxidation

“…Although some studies have shown that AOPP levels increased progressively with the number of MetS components [4,7], we are not aware of any study that have reported the influence of the number of MetS components on protein oxidation and lipid peroxidation measured concomitantly. Bearing in mind the aforementioned reports, we hypothesized that protein oxidation would be more related to MetS and its components than lipid peroxidation.…”

“…The imbalance between prooxidant and antioxidant mechanisms has been considered one of the most important pathophysiological mechanisms of chronic diseases, and there is consistent evidence in the literature to support the hypothesis that oxidative stress could be considered an early event in MetS pathophysiology rather than merely a consequence [4,5]. Advanced oxidation protein products (AOPPs) have been reported as the most appropriate parameter for determination of oxidative stress in MetS patients [6,7].…”

A study of levels of oxidative protein modification markers AOPP and IMA with risk factors of metabolic syndrome

“…Insulin resistance triggers vasoconstriction, hypertriglyceridemia due to increased VLDL synthesis in liver, low HDL resulting in atherosclerosis [18]. Although main mechanism involved in metabolic alterations observed in MetS is insulin resistance, recent studies show that oxidative stress and chronic low level inflammation play important roles in MetS-related manifestations, including atherosclerosis, endothelial dysfunction and hypertension [19]. Moreover, data suggest that oxidative stress is not merely a consequence but it is an early event in the pathogenesis of chronic diseases.…”