Oxygen-Derived Free Radicals as Mediators of Varicose Vein Wall Damage

Farbiszewski, R; Głowiński, Jerzy; Makarewicz-Plonska, Marzena; Chwiecko, M.; Ostapowicz, Roman; Głowiński, S

doi:10.1177/153857449603000109

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…Concentration of thiol groups were significantly lower compared to controls. 24 In this study, we did not find significant changes in the concentration of GSH in the plasma and in the VV wall of patients with VV compared to control.…”

Section: Discussioncontrasting

confidence: 55%

Antioxidative mechanism in the course of varicose veins

et al. 2017

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Objective Our objective was to evaluate the state of oxidative stress in the great saphenous varicose vein wall and blood of varicose vein patients taken from the antecubital vein. Methods The superoxide dismutase, reduced glutathione (GSH) and total antioxidant status were measured with commercially available colorimetric kits in erythrocytes, plasma and varicose vein wall of 65 patients (second degree of clinical state classification, etiology, anatomy and pathophysiology) aged 22-70 (49 women, 16 men) in comparison to normal great saphenous vein walls collected from 10 patients who underwent coronary artery bypass graft and blood collected from 20 healthy individuals. Results A statistically significant decrease (p < 0.001) in superoxide dismutase activity in erythrocytes and the increase (p < 0.05) in superoxide dismutase activity in varicose vein has been observed. There have been no significant changes in the concentration of GSH in plasma and in varicose vein. The decreased concentration of total antioxidant status in plasma (p < 0.001) and in varicose vein wall (p < 0.05) in comparison to the control has been noticed. Conclusion The varicose vein patients are affected by oxidative stress. Our results indicate impaired antioxidant defense mechanism in the blood of varicose vein patients. In contrast to the blood, an increased process of antioxidant defense in the varicose vein wall was noticed.

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Section: Discussioncontrasting

confidence: 55%

Antioxidative mechanism in the course of varicose veins

et al. 2017

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“…On the basis of experimental and clinical evidence collected for the past decade, it is possible to suggest that the cause of dilatation of the varicose vein is in the vascular wall [ 12 , 13 ]. The “valvular” theory, suggesting valvular incompetence, has been criticized in a number of biochemical and morphological studies [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Potential Risk Factors for Varicose Veins with Superficial Venous Reflux

Kapısız¹,

Kulaoğlu²,

Fen³

et al. 2014

International Journal of Vascular Medicine

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The objective of the study is to evaluate a range of potential risk factors in the etiology of varicose veins with superficial venous reflux. Forty-nine patients attending a cardiovascular surgery clinic for the management of varicose disease between 2009 and 2010 were enrolled for the study. The age range of the patient group was 44,04 ± 15,05 years and female/male (F/M) ratio was 30/19. Twenty-six normal, healthy volunteers with the age of 40,94 ± 13,60 years and with the female/male ratio of 15/11 acted as control subjects. We investigated several parameters including body mass index, age, birth number > 1, standing for a long time (standing for 8 or more hours without taking a break), systemic diseases, family history, venous Doppler fındings, the levels of homocysteine, ferritin, vitamin B12, and hemoglobin, sedimentation rate, mean corpuscular volume, low density lipoprotein, and rheumatoid factor of the patient group and the control group. We also determined the contribution of the methylene tetrahydrofolate reductase 677 C>T and 1298 A>C gene polymorphisms and FV Leiden in both groups. In this small study, there appears to be no association between varicose veins and body mass index, smoking, type 2 DM, hypertension, family history, and birth number. A history of increased standing duration period (>8 hours) and rheumatoid factor positivity have association with varicose veins with superficial venous reflux.

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“…On the other hand, healing effects attributed to the seed extract of Aesculus hippocastanum, i.e. in venous and inflammatory disorders, are known to be closely related with its potential against the oxidative stress in the body (Farbiszewski et al, 1996;Rathee et al, 2009). Moreover, regulation of antioxidant defense systems is critically important to avoid from the possible toxicity of the medicines in the body.…”

Section: Treatmentmentioning

confidence: 98%