Oxygen-mediated myocardial damage during ischameia and reperfusion: Role of the cellular defences against oxygen toxicity

Ferrari, Roberto; Ceconi, Claudio; Curello, Salvatore; Guarnieri, Carlo; Caldarera, Claudio Marcello; Albertini, Alberto; Visioli, O

doi:10.1016/s0022-2828(85)80074-2

Cited by 352 publications

(113 citation statements)

References 31 publications

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“…Ischaemia induces metabolic alterations capable of reducing the defense mechanisms of heart against oxygen toxicity, depending on the severity of ischaemic damage. Ischaemia shifts the redox state of cell towards oxidation, GSH and protein-SH content being significantly reduced (32) .The significantly decreased levels in our study could be secondary to increased oxidative stress. Other eminent authors also reported a significantly decreased activity of SOD in CAD patients (7,29,33).…”

Section: Resultsmentioning

confidence: 42%

Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease

Kaur

Bedi²,

Kaur³

et al. 2008

Indian J Clin Biochem

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Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Traditional risk factors account for only half of the morbidity and mortality from coronary artery disease. There is substantial evidence that oxidative stress plays the major role in the atherosclerotic process. The present study was undertaken to evaluate the level of lipid peroxidation (by measuring malondialdehyde) and antioxidant enzymes (ceruloplasmin, glutathione, superoxide dismutase) in coronary artery disease. Serum malondialdehyde levels and serum ceruloplasmin levels were significantly raised in all the subgroups of study group as compared to control group (p<0.001). Whole blood glutathione levels and hemolysate superoxide dismutase activity was significantly decreased in all the subgroups of study group as compared to control group (p<0.001). Above results suggests that the patients of coronary artery disease show increased oxidative stress and decreased levels of antioxidant enzymes. So it is recommended that the management protocol for coronary artery disease patients should include antioxidant supplementation along with simultaneous lowering of lipid peroxidation.

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Section: Resultsmentioning

confidence: 42%

Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease

Kaur

Bedi²,

Kaur³

et al. 2008

Indian J Clin Biochem

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“…Ischaemia shifts the redox state of cell towards oxidation, GSH and protein-SH content being significantly reduced. [73] The significantly decreased levels in our study could be secondary to increased oxidative stress. In the present study, the decreased activity or level of antioxidant molecules measured could have resulted from increased free radical generation.…”

Section: Discussionmentioning

confidence: 54%

Lipid peroxidation the levels of antioxidant enzymes in hypertension

Amanullah

Zaman

Rahman³

et al. 2012

Free Radicals and Antioxidants

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“…Glutathione reductase is a flavoprotein that permits the conversion of oxidized glutathione (GSSG) to reduced Glutathione (GSH) by the oxidation pf NADPH to NADP + 39 . Glutathione, the first line defense against ROS, is a readily available source of endogenous sulfhydryl (-SH) groups 40 . Inactivation of glutathione reductase in the heart leads to the accumulation of GSSG and increases the susceptibility of myocardial membrane to reactive oxygen metabolites and lipoperoxidation necrotic damage [41][42][43] .…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Potential of Methanol Extract of <i>Costus Afer</i> Leaf on Carbon Tetrachloride-Induced Cardiotoxicity in Albino Rats

Njoku

Nwodo

Ogugofor

2017

AJPRHC

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Costus afer leaf extract is one of the native heritages of folklore medicine in Nigeria, used for the treatment of various disease conditions. Therefore this study was undertaken to evaluate the cardioprotective potential of the methanol extract of Costus afer leaves on CCl 4 -induced cardiotoxicity in albino rats. Twenty-eight (28) albino rats were divided into four main groups: normal control (normal saline only), CCl 4 control (saline and CCl 4 ), aspirin treated (1.2 mg/kg b.w aspirin and CCl 4 ) and Costus afer extract treated (extract and CCl 4 ) groups. Costus afer extract was administered in four doses; 100, 200, 300, and 400 mg/kg b.w. p.o for 7 days. On day 7, CCl 4 (2.5 ml) cardiotoxicity was induced in animals of CCl 4 control, aspirin treated and extract pre-treatment groups. The parameters studied in this respect were cardiac biomarker enzymes; Creatine Kinase (CK), Aspartate Transaminases (AST) and Lactate Dehydrogenase (LDH), serum lipid profile; Triacylglycerol (TAG), Total Cholesterol (TC), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and artherogenic index (AR), lipid peroxidation; malondialdehyde (MDA) level and enzymatic antioxidant levels of cardiac tissue homogenate; Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Reductase (GR). CCl 4 intoxication produced significant (p < 0.05) increases in cardiac biomarker enzymes, serum lipid profile (TAG, TC, and LDL) along with enhanced lipid peroxidation in heart, while significant (p < 0.05) decreases in enzymatic antioxidant activities and HDL contents were also observed when compared to normal control. Costus afer leaf extract protected against CCl 4 cardiotoxic effect by restoring the cardiac functions alterations, augmenting antioxidant activities, reducing lipid peroxidation and improving lipid profile levels near normal. From the results, Costus afer leaves expressed cardioprotective potential and could be helpful in the management of cardiac dysfunction.

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Oxygen-mediated myocardial damage during ischameia and reperfusion: Role of the cellular defences against oxygen toxicity

Cited by 352 publications

References 31 publications

Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease

Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease

Lipid peroxidation the levels of antioxidant enzymes in hypertension

Cardioprotective Potential of Methanol Extract of <i>Costus Afer</i> Leaf on Carbon Tetrachloride-Induced Cardiotoxicity in Albino Rats

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