Oxygen plasma induced hydrophilicity of Parylene-C thin films

Trantidou, Tatiana; Prodromakis, Themis; Toumazou, C.

doi:10.1016/j.apsusc.2012.06.112

Cited by 61 publications

(70 citation statements)

References 18 publications

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“…As shown before, the degree of alignment is a function of the oxygen plasma process conditions, 2 which further define the degree of the induced hydrophilicity and substrate microtopography. 21 While we have previously shown that Ca 2+ cycling of NRVM on micropatterned Parylene C films is significantly improved compared to unstructured cultures, 2 in this study, we did not observe any significant changes in the Ca 2+ transients of cells cultured on thin and thick micropatterned Parylene C substrates. Many studies have previously associated cellular alignment and sarcomeric organization with improved Ca 2+ physiology of NRVM on structured tissue substrates.…”

Section: Discussioncontrasting

confidence: 40%

“…We have previously demonstrated a thickness-dependent surface water affinity of Parylene C thin films ranging from 50 nm to 12 mm thickness. 21 In particular, average contact angles of a 10 mL droplet of DI water on Parylene C-coated glasses were 78.85°for 2 mmthick films and 88.30°for 10 mm-thick films.…”

Section: Discussionmentioning

confidence: 99%

“…We employed Parylene C films of two distinct thicknesses (2 and 10 mm), as we concluded that the surface hydrophobicity does not significantly change below 2 mm and above 10 mm-film thickness. 21 We selectively changed the material's hydrophobicity, creating sequential hydrophilic and hydrophobic lines of 10 mm width. This particular pattern was adopted based on previous experiments with different pattern layouts, because it induced the greatest cellular alignment and nuclear elongation.…”

Section: Discussionmentioning

confidence: 99%

“…18 In fact, we have previously demonstrated that Parylene C exhibits a thickness-dependent hydrophobicity, with thicker films being more hydrophobic than thinner films. 21 In this study, we hypothesize that certain morphological parameters of structured cardiac myocytes on micropatterned Parylene C films can be further manipulated by controlling the film thickness and thus the degree of surface hydrophobicity. To test the hypothesis, we cultured NRVM on glass substrates coated with 2 and 10 mm-thick Parylene C films, which were selectively plasma oxidized to create local hydrophilic areas for cell attachment.…”

Section: Introductionmentioning

confidence: 99%

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Surface Chemistry and Microtopography of Parylene C Films Control the Morphology and Microtubule Density of Cardiac Myocytes

Trantidou

Humphrey

Poulet

et al. 2016

Tissue Engineering Part C: Methods

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Cell micropatterning has certainly proved to improve the morphological and physiological properties of cardiomyocytes in vitro; however, there is little knowledge on the single cell-scaffold interactions that influence the cells' development and differentiation in culture. In this study, we employ hydrophobic/hydrophilic micropatterned Parylene C thin films (2-10 mm) as cell microscaffolds that can control the morphology and microtubule density of neonatal rat ventricular myocytes (NRVM) by regulating their adhesion area on Parylene through a thickness-dependent hydrophobicity. Structured NRVM on thin films tend to bridge across the hydrophobic areas, demonstrating a more spread-out shape and sparser microtubule organization, while cells on thicker films adopt a cylindrical (in vivo-like) shape (contact angles at the level of the nucleus are 64.51°and 84.73°, respectively) and a significantly ( p < 0.05) denser microtubule structure. Ion scanning microscopy on NRVM revealed that cells on thicker membranes were significantly ( p < 0.05) smaller in volume, but more elongated. The cylindrical shape and a significantly denser microtubule structure indicate the ability to influence cardiomyocyte phenotype using patterning and manipulation of hydrophilicity. These combined bioengineering strategies are promising tools in the generation of more representative cardiomyocytes in culture.

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Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surface Chemistry and Microtopography of Parylene C Films Control the Morphology and Microtubule Density of Cardiac Myocytes

Trantidou

Humphrey

Poulet

et al. 2016

Tissue Engineering Part C: Methods

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“…The effect of the electron beam through water vapor is therefore different from oxygen plasma treatment, which is well known to increase the hydrophilicity of parylene-C. [46][47][48][49] Furthermore, the effect of an oxygen plasma treatment tends to weaken in a few days as the parylene-C film recovers some of its hydrophobicity. [50] In our method the patterns retain superhydrophilicity even after a year, making the treatment practically permanent.…”

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confidence: 99%

Maskless, High‐Precision, Persistent, and Extreme Wetting‐Contrast Patterning in an Environmental Scanning Electron Microscope

Liimatainen

Shah

Johansson

et al. 2016

Small

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1 This is the pre-peer reviewed version of the following article:Liimatainen, V., Shah, A., Johansson, L.-S., Houbenov, N. and Zhou, Q. (2016), Maskless, High-Precision, Persistent, and Extreme Wetting-Contrast Patterning in an Environmental Scanning Electron Microscope. Small. doi:10.1002/smll.201503127, which Since the past decade, micro-and nanopatterns with high wetting contrast for water have been reported on natural [1,2] and man-made [3,4] surfaces. Such patterns have found uses in a diverse set of applications, including water collection from humid air mimicking desert beetles; [5] enhancing boiling heat transfer; [6] microelectromechanical systems (MEMS) assembly using surface tension-driven self-alignment; [7] arranging nanostructures in ordered arrays [8] for 2 nanophotonic devices e.g. antennas, filters and optical processing circuits; [9] transport of both droplets [10] and liquid flows [11] for lab-on-a-chip devices; and solving cross-contamination and cell migration problems in ultrahigh-density living cell microarrays. [12] Many highly successful methods utilizing well-developed technologies have been employed to produce those micro and nanoscale wetting features, from conventional photolithographic methods, laser interference lithography, [13,14] electron beam lithography (EBL), [15,16] to near-field scanning optical microscopy (NSOM), [17,18] microcontact printing (µCP) [19,20] and pulsed laser beams; [21,22] however, these techniques also have their limitations. For example, in conventional photolithography, sub-µm resolution requires expensive equipment and the wet processing steps may damage the often delicate surface structure of superhydrophobic substrates; laser interference lithography can only produce features in the shape of a few types of interference patterns; microcontact printing techniques use a stamping process that is challenging to apply on rough surfaces; [23] focused, pulsed laser beams have a resolution of few µm, limited by the beam spot size; and specific, photo-or electron sensitive materials are required for NSOM and EBL. The pursuit for an effective method of fabricating highresolution wetting patterns with extreme wetting contrast is still ongoing.One potential solution is direct electron beam writing, where the beam modifies the surface directly without any pattern-transferring layer or further processing steps. In previous works, the effect of electron beams on surface wetting properties has been studied; e.g. high-energy electron beams (> 500 keV) can tune the wettability of poly(ethylene terephthalate) (PET) films, [24] poly-l-lactic acid (PLLA), [25] rubber [26] and textile fabrics, [27] where the maximum changes in water contact angles varied from 15° to 32°; and low-energy electron beams (< 0.5 keV) [28,29] can increase the water contact angle by 71° on a silicon dioxide surface, and by 25° on a zinc oxide nanomaterial. In the aforementioned works, electron beam has not been controlled to produce wetting patterns in specific shapes on the surface. 3In this p...

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Vapor‐Phase Synthesis of Poly(para‐xylylene): From Coatings to Porous and Hierarchical Materials

Hu,

Lee,

Ramli

et al. 2024

Adv Funct Materials

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Poly(para‐xylylene) (PPX) is a robust and biocompatible coating material that is widely used in various applications, including electronics, aerospace and defense materials, automotive materials, and biomaterials. In this progress report, recent developments in PPX technology ranging from the advancement of physical chemistry properties and structural properties for device integration to the transformation of 3D monolith materials of PPX with controls in outer and inner structures at the micro‐ and nanometer scales are highlighted. Based on emerging chemistry studies on [2.2]paracyclophanes, which are primarily used precursors to synthesize PPX via vapor deposition polymerization, functionalization, and the creation of a wide variety of functional PPX derivatives are demonstrated without resistance. Widely used as an interface coating material, PPX is processed to form integrated structural materials and has already been found to be useful in the market as part of electronic and medical implant products. Using a newly innovated transformation to fabricate PPX through templates (metal‐organic frameworks, liquid crystal, ice crystal), 3D monoliths, nanoscale particles, hierarchical and gradient interior structures, and dynamically transformable shapes at the nanoscale are demonstrated. A vast landscape of novel applications and device products is expected based on the already established R&D and market maturity of PPX.

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Oxygen plasma induced hydrophilicity of Parylene-C thin films

Cited by 61 publications

References 18 publications

Surface Chemistry and Microtopography of Parylene C Films Control the Morphology and Microtubule Density of Cardiac Myocytes

Surface Chemistry and Microtopography of Parylene C Films Control the Morphology and Microtubule Density of Cardiac Myocytes

Maskless, High‐Precision, Persistent, and Extreme Wetting‐Contrast Patterning in an Environmental Scanning Electron Microscope

Vapor‐Phase Synthesis of Poly(para‐xylylene): From Coatings to Porous and Hierarchical Materials

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