Oxymetazoline plus dexpanthenol in nasal congestion

Jagade, Mohan; Langade, Deepak; Pophale, Rupesh; Prabhu, Arun

doi:10.1007/s12070-008-0125-7

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…Given the mechanism of action, it cannot be easily explained why dexpanthenol not only reduces the sign of redness and the symptom of rhinorrhea but also the swelling of the mucosa, leading to a strong reduction of the feeling of nasal blockage in most patients within 3 days. This antiobstructive synergy with a nasal decongestant, which has already been described by Jagade, although not under double-blind, placebo-controlled conditions, needs further clarification [ 20 ].…”

Section: Discussionmentioning

confidence: 93%

“…While the effects of the use of nasal sprays containing decongestants alone mainly focus on the improvement of nasal obstruction, additional effects can be expected from adding a nurturing substance, such as dexpanthenol. These effects have been studied in two double-blind, active-controlled clinical trials comparing the monosubstance xylometazoline with the combination of dexpanthenol and xylometazoline [ 19 ], or oxymetazoline and dexpanthenol [ 20 ]. Kehrl et al showed that in patients suffering from acute rhinitis, the combined administration of xylometazoline and dexpanthenol was more effective than xylometazoline monotherapy in decreasing rhinorrhea, nasal obstruction, conchal swelling, and hyperemia of the nasal mucosa.…”

Section: Nasal Decongestants In Acute Rhinitismentioning

confidence: 99%

“…The authors speculated that the more pronounced effect of this combination on signs and symptoms of acute rhinitis was due to the protection of the epithelium by dexpanthenol. In their prospective, randomized, and blinded study involving 100 patients in two groups receiving either oxymetazoline 0.05% with dexpanthanol 5% (OD) or xylometazoline 0.1% (XO) nasal drops, Jagade et al found more pronounced relief from nasal congestion in the group receiving the combination treatment [ 20 ]. This difference reached statistical significance.…”

Section: Nasal Decongestants In Acute Rhinitismentioning

confidence: 99%

See 2 more Smart Citations

Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays

Mösges

Shah‐Hosseini

Hucke³

et al. 2017

Adv Ther

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Nasal blockage is the most bothersome symptom of acute rhinitis. Nasal decongestant sprays containing alpha-sympathomimetics, such as oxymetazoline and xylometazoline, have a rapid onset of action. However, this effect decreases with repeated application and, furthermore, the ciliary function of the nasal mucosa is practically paralyzed. Dexpanthenol promotes cell proliferation and protects the epithelium. Combining these two agents has demonstrated beneficial synergetic effects on the symptoms of acute rhinitis. In a post hoc analysis of a large-scale double-blind, active-controlled study including 152 patients, we could demonstrate that the benefit of added dexpanthenol appears as early as on the third day of the combined application of xylometazoline and dexpanthenol in terms of complete or near-to-complete freedom from symptoms. After 5 days, 47% of the patients were cured under the combined treatment compared with only 1% under xylometazoline monotherapy. These data show that the addition of dexpanthenol to an alpha-sympathomimetic nasal spray not only improves its tolerability but also further increases its effectiveness and leads to expedited cure.Funding: Klosterfrau Healthcare Group.

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Section: Discussionmentioning

confidence: 93%

Section: Nasal Decongestants In Acute Rhinitismentioning

confidence: 99%

Section: Nasal Decongestants In Acute Rhinitismentioning

confidence: 99%

See 1 more Smart Citation

Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays

Mösges

Shah‐Hosseini

Hucke³

et al. 2017

Adv Ther

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“…Решением для преодоления данного побочного действия является использование назальных сосудосуживающих препаратов без консер-вантов или добавление в препарат веществ, обладающих цилиопротективным эффектом [9,10]. Наилучшим реше-нием для уменьшения отрицательного воздействия деконгестанта и вспомогательных веществ, входящих в состав препарата, является использование комбиниро-ванных лекарственных средств с декспантенолом [11,12]. Еще одним возможным путем решения проблемы мест-ных побочных эффектов от применения назальных сосу-досуживающих препаратов является параллельное использование средств для ирригационно-элиминацион-ной терапии, в основном изотонических растворов сте-рильной морской воды [13].…”

unclassified

“…Консерванты, содержащиеся в составе большинства деконгестантов, будут усиливать уже существующую цилиарную дисфунк-цию, что обычно выражается в виде жалоб пациентов на жжение или сухость в полости носа после применения данных препаратов. Возможным решением данной про-блемы может стать применение назальных препаратов, не содержащих антисептиков, консервантов, или исполь-зование комбинированных лекарственных средств с декспантенолом [11,12].…”

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Current Aspects of Use of Nasal Vasoconstrictors and Adjunctive Agents in Pediatric Practice

Тулупов¹,

Fedotov²,

Карпова³

et al. 2018

Med. sov.

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Examining the effect ofWithania somniferasupplementation on muscle strength and recovery: a randomized controlled trial

Wankhede¹,

Langade

Joshi³

et al. 2015

Journal of the International Society of Sports Nutrition

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BackgroundWithania somnifera (ashwagandha) is a prominent herb in Ayurveda. This study was conducted to examine the possible effects of ashwagandha root extract consumption on muscle mass and strength in healthy young men engaged in resistance training.MethodsIn this 8-week, randomized, prospective, double-blind, placebo-controlled clinical study, 57 young male subjects (18–50 years old) with little experience in resistance training were randomized into treatment (29 subjects) and placebo (28 subjects) groups. Subjects in the treatment group consumed 300 mg of ashwagandha root extract twice daily, while the control group consumed starch placebos. Following baseline measurements, both groups of subjects underwent resistance training for 8 weeks and measurements were repeated at the end of week 8. The primary efficacy measure was muscle strength. The secondary efficacy measures were muscle size, body composition, serum testosterone levels and muscle recovery. Muscle strength was evaluated using the 1-RM load for the bench press and leg extension exercises. Muscle recovery was evaluated by using serum creatine kinase level as a marker of muscle injury from the effects of exercise.ResultsCompared to the placebo subjects, the group treated with ashwagandha had significantly greater increases in muscle strength on the bench-press exercise (Placebo: 26.4 kg, 95 % CI, 19.5, 33.3 vs. Ashwagandha: 46.0 kg, 95 % CI 36.6, 55.5; p = 0.001) and the leg-extension exercise (Placebo: 9.8 kg, 95 % CI, 7.2,12.3 vs. Ashwagandha: 14.5 kg, 95 % CI, 10.8,18.2; p = 0.04), and significantly greater muscle size increase at the arms (Placebo: 5.3 cm2, 95 % CI, 3.3,7.2 vs. Ashwagandha: 8.6 cm2, 95 % CI, 6.9,10.8; p = 0.01) and chest (Placebo: 1.4 cm, 95 % CI, 0.8, 2.0 vs. Ashwagandha: 3.3 cm, 95 % CI, 2.6, 4.1; p < 0.001). Compared to the placebo subjects, the subjects receiving ashwagandha also had significantly greater reduction of exercise-induced muscle damage as indicated by the stabilization of serum creatine kinase (Placebo: 1307.5 U/L, 95 % CI, 1202.8, 1412.1, vs. Ashwagandha: 1462.6 U/L, 95 % CI, 1366.2, 1559.1; p = 0.03), significantly greater increase in testosterone level (Placebo: 18.0 ng/dL, 95 % CI, -15.8, 51.8 vs. Ashwagandha: 96.2 ng/dL, 95 % CI, 54.7, 137.5; p = 0.004), and a significantly greater decrease in body fat percentage (Placebo: 1.5 %, 95 % CI, 0.4 %, 2.6 % vs. Ashwagandha: 3.5 %, 95 % CI, 2.0 %, 4.9 %; p = 0.03).ConclusionThis study reports that ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program.

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Oxymetazoline plus dexpanthenol in nasal congestion

Abstract: Oxymetazoline and dexpanthenol combination has a better efficacy, shorter recovery time, causes lesser rebound congestion and has better tolerability than xylometazoline.

Cited by 4 publications

References 8 publications

Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays

Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays

Current Aspects of Use of Nasal Vasoconstrictors and Adjunctive Agents in Pediatric Practice

Examining the effect ofWithania somniferasupplementation on muscle strength and recovery: a randomized controlled trial

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