Oxyresveratrol as the Potent Inhibitor on Dopa Oxidase Activity of Mushroom Tyrosinase

Shin, Nam Ho; Ryu, Shi Yong; Choi, Eun Ju; Kang, Seh Hoon; Chang, Il Moo; Min, Kyung Rak; Kim, Youngsoo

doi:10.1006/bbrc.1998.8169

Cited by 207 publications

(116 citation statements)

References 11 publications

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“…Origanum vulgare (whitening agent: origanoside, a glycosylated phenolic compound) and Scutelleria baicalensis (whitening agent: baicalein, a flavone) extracts, as well as Morus (containing chalcones and stilbenoids) and Citrus (containing flavones, flavanones, and flavanols) species extracts also display interesting whitening properties [12,14,15,19,[161][162][163][164][165][166][167]. It was proven that oral intake for one year of pro-anthocyanidin-rich extract from grape seeds (Vitis vinifera) reduced the hyperpigmentation of women suffering chloasma [43].…”

Section: State Of the Artmentioning

confidence: 99%

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

et al. 2016

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Abstract:With the public's growing interest in skin whitening, lightening ingredients only used under dermatological supervision until recently, are more and more frequently incorporated into cosmetic formulas. The active agents that lighten skin tone are either natural or synthetic substances, and may act at various levels of melanogenesis. They are used to treat various skin pigmentation disorders or simply to obtain a lighter skin tone as whiter skin may be synonymous of wealth, health, youth, and/or beauty in different cultures. However, recent studies demonstrated the adverse effects of some of these ingredients, leading to their interdiction or restricted use under the European Directive and several other international regulations. After an overview of skin whitening practices and the associated risks, this article provides insight into the mechanisms involved in melanin synthesis and the biological assays available to attest the lightening activity of individual ingredients. The legislation dealing with the use of skin lighteners is then discussed. As traditional depigmenting agents such as hydroquinone and corticosteroids are of safety concern, the potential of natural extracts has been investigated more and more; finally, a synthesis of three years of research in our laboratory for such plant extracts will be given.

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Section: State Of the Artmentioning

confidence: 99%

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

et al. 2016

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“…6 Resveratrol has a number of naturally occurring analogs such as pterostilbene, piceatannol and oxyresveratrol, which may have anti-inflammatory, anti-carcinogenic, cell cycle inhibitory and anti-oxidant effects. [35][36][37][38] Since wine contains higher levels of resveratrol than spirits and beer, it is plausible that wine may influence EOC risk independently of the alcohol that it contains. Some epidemiologic studies have shown that high levels of resveratrol found in wine may reduce the risk of EOC, 18,20,25 suggesting the strong protective effect of resveratrol in wine on the development of EOC.…”

Section: Discussionmentioning

confidence: 99%

Wine drinking and epithelial ovarian cancer risk: a meta-analysis

Kim

Shouten

et al. 2010

J Gynecol Oncol

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Objective: Wine has been the focus in the prevention of epithelial ovarian cancer (EOC) development because resveratrol abundant in wine has anti-carcinogenic properties. However, epidemiologic results have been heterogenous in the chemopreventive effect of wine on the development of EOC. Thus, we performed a meta-analysis for comparing EOC risk between wine and never drinkers using previous related studies. Methods: After extensive search of the literature between January 1986 and December 2008, we analyzed 10 studies (3 cohort and 7 case control studies) with 135,871 women, who included 65,578 of wine and 70,293 of never drinkers. Results: In all studies, there was no significant difference in EOC risk between wine and never drinkers (odds ratio [OR], 1.13; 95% confidence interval [CI], 0.92 to 1.38; random effects). When we performed re-analysis according to the study design, 3 cohort and 7 case control studies showed that there were also no significant differences in EOC risk between wine and never drinkers, respectively (OR, 1.44 and 1.04; 95% CI, 0.74 and 2.82 and 0.88 to 1.22; random effects). In sub-analyses using 2 case-control studies, EOC risk was not different between former and never drinkers (OR, 1.12; 95% CI, 0.87 to 1.44; fixed effect), and between current and former drinkers (OR, 0.74; 95% CI, 0.41 to 1.34; random effects). Conclusion: Although resveratrol, abundantly found in wine, is a promising naturally occurring compound with chemopreventive properties on EOC in preclinical studies, this meta-analysis suggests the epidemiologic evidence shows no association between wine drinking and EOC risk.

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“…잘 알려진 tyrosinase 억제 물질인 누룩곰팡이로부터 분리된 kojic acid [13], hydroquinone [15], oxyresveratrol [17], 그리고 p-hydroxybenzyl alcohol [14] (Fig. 1, 2 …”

Section: 서 론unclassified

Inhibitory Effects of Fucoidan on Melanin Synthesis and Tyrosinase Activity

2009

Journal of Life Science

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Korea -Melanogenesis is a physiological process that results in the synthesis of melanin pigments.Tyrosinase is a key enzyme for melanin biosynthesis, and hyperpigmentation disorders are associated with abnormal accumulation of melanin pigments, which can be improved by treatment with depigmenting agents. Among the possible melanin-reducing compounds, tyrosinase inhibitors are most promising for preventing and treating pigmentation disorder and are used as skin-whitening agents in the cosmetic industry. In the present study, the effects of fucoidan on melanogenesis and tyrosinase activity of B16F10 melanoma cells were investigated. Melanin synthesis and tyrosinase activity in B16F10 melanoma cells were decreased in a dose-dependent manner by fucoidan. Melanin production and tyrosinase activity in B16F10 melanoma cells stimulated by α-melanocyte stimulating hormone (α-MSH) were inhibited by fucoidan with a dose-dependent manner compared to control. Fucoidan inhibited tyrosinase activity of B16F10 melanoma cells with a dose-dependent manner as assessed by 3,4-dihydroxyphenylalanine (DOPA) staining. In conclusion, these findings indicate that fucoidan, which inhibit melanin synthesis and tyrosinase activity, is an effective skin-whitening agent.

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Oxyresveratrol as the Potent Inhibitor on Dopa Oxidase Activity of Mushroom Tyrosinase

Cited by 207 publications

References 11 publications

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

Wine drinking and epithelial ovarian cancer risk: a meta-analysis

Inhibitory Effects of Fucoidan on Melanin Synthesis and Tyrosinase Activity

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