Oxytocin-augmented labor and risk for autism in males

Weisman, Omri; Agerbo, Esben; Carter, C. Sue; Harris, James C.; Uldbjerg, Niels; Henriksen, Tine Brink; Thygesen, Malene; Mortensen, Preben Bo; Leckman, James F.; Dalsgaard, Søren

doi:10.1016/j.bbr.2015.02.028

Cited by 70 publications

(56 citation statements)

References 50 publications

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“…International standards for presenting the results of literature review PRISMA (2017) were considered. Two of the inclusion criteria should be mentioned: 1) the search time frame was restricted to articles that were published in 2013 or later, and 2) only studies that demonstrated an association between the use of oxytocin and ASD by means of a multivariate analysis and appropriate consideration of the known and most relevant perinatal risk factors were included (Gregory, et al, 2013;Clark, et al, 2015;Weisman, et al, 2015;Oberg, et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Po pregledu izvlečkov smo izključili vse pregledne članke, pisma urednikom in članke, ki so opisovali raziskave na živalih. Pregledali smo celotno besedilo preostalih petih člankov in ocenili kakovost raziskav (Gregory, et al, 2013;Clark, et al, 2015;Weisman, et al, 2015;Oberg, et al 2016;Smallwood, et al, 2016). V končni pregled smo vključili štiri raziskave.…”

Section: Metode Pregledaunclassified

“…kakovosti, so opazovalne raziskave. Štiri od petih raziskav, ki smo jih ocenjevali, so bile retrospektivne kohortne raziskave, narejene na podlagi pregleda velikih epidemioloških baz podatkov z ustreznim upoštevanjem motečih dejavnikov, kot so spol otroka, način poroda (vaginalni porod vs. carski rez), starost matere, pariteta, fetalni distres med porodom, medenična vstava in nekateri zapleti v nosečnosti (preeklampsija, nosečnostna sladkorna bolezen in zastoj plodove rasti) (Gregory, et al, 2013;Clark, et al, 2015;Weisman, et al, 2015;Oberg, et al, 2016). Vsi našteti dejavniki so namreč znani perinatalni dejavniki tveganja za SAM, zato jih je potrebno upoštevati, kadar preučujemo morebitno povezavo med uporabo oksitocina med porodom in SAM (Hultman, et al, 2002;Glasson, et al, 2004;Larsson, et al, 2005;Durkin, et al, 2008;Williams, et al, 2008;Bilder, et al, 2009;Gardener, et al, 2009;Burstyn, et al, 2010).…”

Section: Ocena Kakovosti Pregleda In Opis Obdelave Podatkovunclassified

“…After reviewing abstracts we excluded all review articles, letters to editors and articles describing research conducted on animals. We reviewed the entire text of the other five articles and assessed the quality of research (Gregory, et al, 2013;Clark, et al, 2015;Weisman, et al, 2015;Oberg, et al 2016;Smallwood, et al, 2016). Four studies were included in the final review.…”

Section: Review Methodsmentioning

confidence: 99%

“…All the trials that were suitable for the assessment of suitability or quality were observational studies. Four of the five studies that we evaluated were retrospective cohort studies conducted on the basis of reviewing large epidemiological databases with relevant consideration of confounding factors like sex of the foetus, methods of childbirth (vaginal delivery vs. Caesarean section), mother's age, parity, foetal distress during labour, breech presentation and some complications during pregnancy (preeclampsia, gestational diabetes and growth retardation) (Gregory, et al, 2013;Clark, et al, 2015;Weisman, et al, 2015;Oberg, et al, 2016). All of the above-mentioned factors are well described perinatal risk factors for ASD, therefore they should be considered when studying the potential association between using oxytocin during labour and ASD (Hultman, et al, 2002;Glasson, et al, 2004;Larsson, et al, 2005;Durkin, et al, 2008;Williams, et al, 2008;Bilder, et al, 2009;Gardener, et al, 2009;Burstyn, et al, 2010).…”

Section: The Quality Assessment Of the Review And The Description Of mentioning

confidence: 99%

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Oxytocin for labour induction or augmentation as a risk factor for autism: systematic literature review

Grosek¹,

Lučovnik

2017

Obzor Zdrav Neg

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Introduction: Some studies have shown a potential association between oxytocin use during labour and autism spectrum disorder (ASD) in children. We performed a systematic review of recent studies examining this association. Methods: Boolean operators (AND/OR) were used to search MEDLINE using the following search criteria: Autistic Disorder or Autism Spectrum Disorder or Autism and Labour Induction or Labour Augmentation. Articles published in English in 2013 or later were considered. Additional studies were identified by reviewing citations. Only studies conducted on people were included. Studies not accounting for potential confounding factors were excluded. Results: Four retrospective cohort studies met the inclusion criteria. One showed an association between labour induction and augmentation and ASD, one showed a weak association between labour augmentation in boys and ASD, and one showed no association between labour induction or augmentation and ASD. The largest study showed a weak association between labour induction and ASD, which was not significant when siblings were analyzed separately. Discussion and conclusion: Recently published studies do not support the hypothesis of a causal relationship between oxytocin use during labour and ASD. Benefits of medically indicated induction or augmentation of labour outweigh the theoretical risk of ASD. IZVLEČEKUvod: Raziskave so pokazale morebitno povezavo med uporabo oksitocina med porodom in avtizmom. Skozi sistematični pregled literature so bile preverjene novejše klinične raziskave s področja povezave med sprožitvijo ali pospeševanjem poroda z oksitocinom in avtizmom. Metode: Z Boolovima operatorjema (AND oz. OR) je bila pregledana bibliografska zbirka MEDLINE s ključnimi besedami avtistična motnja ali spekter avtističnih motenj ali avtizem in sprožitev poroda ali pospeševanje poroda. Vključeni so bili znanstveni članki v angleščini, objavljeni od leta 2013 dalje. Dodatne raziskave so bile identificirane s pregledom citatov. Vključene so bile le raziskave na ljudeh. Izključene so bile raziskave, ki so povezavo med oksitocinom in avtizmom preučevale brez ustreznega upoštevanja morebitnih motečih dejavnikov. Rezultati: Vključitvenim kriterijem so ustrezale štiri retrospektivne kohortne raziskave. Povezavo med uporabo oksitocina med porodom in avtizmom je ena raziskava pokazala pri sprožitvi ali pospeševanju poroda, ena samo pri pospeševanju poroda pri dečkih, ena povezave ni pokazala niti pri sprožitvi niti pri pospeševanju poroda, četrta, največja raziskava je pokazala morebitno šibko povezavo pri sprožitvi poroda, vendar ob analizi sorojencev le-ta ni bila več statistično pomembna. Diskusija in zaključek: Do danes objavljene raziskave niso pokazale klinično pomembne vzročne povezave med uporabo oksitocina med porodom in avtizmom. Dokazane koristi medicinsko indicirane uporabe oksitocina odtehtajo teoretično tveganje za nastanek avtizma.

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Section: Discussionmentioning

confidence: 99%

Section: Metode Pregledaunclassified

Section: Ocena Kakovosti Pregleda In Opis Obdelave Podatkovunclassified

Section: Review Methodsmentioning

confidence: 99%

Section: The Quality Assessment Of the Review And The Description Of mentioning

confidence: 99%

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Oxytocin for labour induction or augmentation as a risk factor for autism: systematic literature review

Grosek¹,

Lučovnik

2017

Obzor Zdrav Neg

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Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population

Xia

Xiao

et al. 2021

JAMA Netw Open

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IMPORTANCE Nonoptimal gestational durations could be associated with neurodevelopmental disabilities, yet evidence regarding finer classification of gestational age and rates of multiple major neuropsychiatric disorders beyond childhood is limited.OBJECTIVE To comprehensively evaluate associations between 6 gestational age groups and rates of 9 major types and 8 subtypes of childhood and adult-onset neuropsychiatric disorders.

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Incidence Rates and Cumulative Incidences of the Full Spectrum of Diagnosed Mental Disorders in Childhood and Adolescence

et al. 2020

Self Cite

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IMPORTANCE Knowledge about the epidemiology of mental disorders in children and adolescents is essential for research and planning of health services. Surveys can provide prevalence rates, whereas population-based registers are instrumental to obtain precise estimates of incidence rates and risks.OBJECTIVE To estimate age-and sex-specific incidence rates and risks of being diagnosed with any mental disorder during childhood and adolescence.

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Oxytocin-augmented labor and risk for autism in males

Cited by 70 publications

References 50 publications

Oxytocin for labour induction or augmentation as a risk factor for autism: systematic literature review

Oxytocin for labour induction or augmentation as a risk factor for autism: systematic literature review

Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population

Incidence Rates and Cumulative Incidences of the Full Spectrum of Diagnosed Mental Disorders in Childhood and Adolescence

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