Oxytocin enhances presynaptic and postsynaptic glutamatergic transmission between rat olfactory bulb neurones in culture

Osako, Yoichi; Otsuka, Tomoko; Taniguchi, Masaru; Oka, Tatsuzo; Kaba, Hideto

doi:10.1016/s0304-3940(00)01779-1

Cited by 29 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…68 However, Oxt facilitates glutamatergic transmission in rat olfactory bulb neurons in culture. 69 We are not aware of similar studies within the CSPP, so future investigations on glutamatergic expression and transmission within the CSPP of OxtÀ/À mice seem warranted.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice

2008

View full text Add to dashboard Cite

It has been previously suggested that oxytocin (Oxt) may act as a natural antipsychotic. To test this hypothesis, we investigated whether disruption of the oxytocin gene (OxtÀ/À) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP). We examined drug-induced changes in the prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating deficits characteristic of several psychiatric and neurological disorders, including schizophrenia. We found that treatment with Amp, Apo and PCP all had effects on PPI. However, in OxtÀ/À mice, but not Oxt þ / þ mice, PCP treatment resulted in large PPI deficits. As PCP is a noncompetitive N-methyl-D-aspartic acid receptor antagonist, these findings suggest that the absence of Oxt alters the glutamatergic component of the PPI.

show abstract

Section: Discussionmentioning

confidence: 99%

Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice

2008

View full text Add to dashboard Cite

show abstract

“…While Yu et al (1996b) found clear indications that transport via the CSF played a role in the effects of paraventricular hypothalamic OT, icv manipulations turned out to be much less effective than direct bulbar administration (Yu et al, 1996a). Inside the olfactory bulb, both mitral and granule cells appear to be involved in the induction of short-and long -term potentiation (Fang et al, 2008;Osako et al, 2000Osako et al, , 2001Yu et al, 1996b). The mitral cells project directly to the supraoptic nucleus Yang, 1989, 1990;Meddle et al, 2007Meddle et al, , 2000 in addition to the more extensively explored projections to anterior olfactory nucleus, piriform cortex and medial and cortical amygdaloid nucei (Ghosh et al, 2011;Kang et al, 2011a,b;Miyamichi et al, 2011;Nagayama et al, 2010;Shipley, 1985;Sosulski et al, 2011).…”

Section: Brain Areas Involved In the Effects Of Otmentioning

confidence: 99%

Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Veening

Olivier

2013

Neuroscience & Biobehavioral Reviews

154

128

View full text Add to dashboard Cite

The intranasal (IN-) administration of substances is attracting attention from scientists as well as pharmaceutical companies. The effects are surprisingly fast and specific. The present review explores our current knowledge about the routes of access to the cranial cavity. 'Direct-access-pathways' from the nasal cavity have been described but many additional experiments are needed to answer a variety of open questions regarding anatomy and physiology. Among the IN-applied substances oxytocin (OT) has an extensive history. Originally applied in women for its physiological effects related to lactation and parturition, over the last decade most studies focused on their behavioral 'prosocial' effects: from social relations and 'trust' to treatment of 'autism'. Only very recently in a microdialysis study in rats and mice, the 'direct-nose-brain-pathways' of IN-OT have been investigated directly, implying that we are strongly dependent on results obtained from other IN-applied substances. Especially the possibility that IN-OT activates the 'intrinsic' OT-system in the hypothalamus as well needs further clarification. We conclude that IN-OT administration may be a promising approach to influence human communication but that the existing lack of information about the neural and physiological mechanisms involved is a serious problem for the proper understanding and interpretation of the observed effects.

show abstract

“…This change in the mother's responsiveness is governed by hormonal changes at parturition, and it is suggested that the oxytocin system participates primarily in this process. Pregnancy and parturition enhance the sensitivity and neural firing in the olfactory bulb in rats, and oxytocin infusion directly into the olfactory bulb increases the firing frequency and spontaneous excitatory postsynaptic currents in granule cells (Yu et al, 1996) via both pre- and postsynaptic mechanisms, a process integral to olfactory recognition memory (Engelmann et al, 1998; Dluzen et al, 2000; Osako et al, 2001). Similar to the responsiveness to pup odors, the response to pup USVs has also been shown to be far more pronounced in mothers than in naïve females (Koch and Ehret, 1989; Okabe et al, 2010); however, the neuroendocrine mechanisms responsible for this change in response to pup USVs has not been elucidated.…”

Section: Neuroendocrine Regulation Of Mother-pup Interactionsmentioning

confidence: 99%

Oxytocin and mutual communication in mother-infant bonding

Nagasawa¹,

Okabe²,

Mogi³

et al. 2012

Front. Hum. Neurosci.

161

View full text Add to dashboard Cite

Mother-infant bonding is universal to all mammalian species. In this review, we describe the manner in which reciprocal communication between the mother and infant leads to mother-infant bonding in rodents. In rats and mice, mother-infant bond formation is reinforced by various social stimuli, such as tactile stimuli and ultrasonic vocalizations (USVs) from the pups to the mother, and feeding and tactile stimulation from the mother to the pups. Some evidence suggests that mother and infant can develop a cross-modal sensory recognition of their counterpart during this bonding process. Neurochemically, oxytocin in the neural system plays a pivotal role in each side of the mother-infant bonding process, although the mechanisms underlying bond formation in the brains of infants has not yet been clarified. Impairment of mother-infant bonding, that is, deprivation of social stimuli from the mother, strongly influences offspring sociality, including maternal behavior toward their own offspring in their adulthood, implying a "non-genomic transmission of maternal environment," even in rodents. The comparative understanding of cognitive functions between mother and infants, and the biological mechanisms involved in mother-infant bonding may help us understand psychiatric disorders associated with mother-infant relationships.

show abstract

Oxytocin enhances presynaptic and postsynaptic glutamatergic transmission between rat olfactory bulb neurones in culture

Cited by 29 publications

References 15 publications

Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice

Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice

Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Oxytocin and mutual communication in mother-infant bonding

Contact Info

Product

Resources

About