[P‐041]: MCI progressors and non‐progressors: Neuropsychological profiles fail to guarantee the prognosis

Chertkow, Howard; Bocti, Christian; Bergman, Howard; Whitehead, Victor; Verret, Louis; McKelvey, Roger

doi:10.1016/j.jalz.2005.06.103

Cited by 2 publications

(1 citation statement)

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“…4,5 According to several works, 6,7 cognitive training has been found to have a protective role in older adults and mainly those who are at risk of developing dementia. Moreover, Chertkow et al, (2006) 8 supported that structured intervention in MCI can reverse and prevent dementia onset through improvement of daily functionality.…”

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confidence: 99%

Longitudinal Cognitive and Physical Training Effectiveness in MCI, Based on the Experience of the Alzheimer’s Hellas Day Care Centre

Poptsi

Tsatali

Agogiatou

et al. 2021

J Geriatr Psychiatry Neurol

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This study assesses the effectiveness of a multicomponent Longitudinal Cognitive Training (CT) program plus physical exercise (PE) for people with Mild Cognitive Impairment (MCI). 155 people with MCI, completed a 3 years (3Y) CT+PE, whilst 133 were control. Neuropsychological assessment was performed at baseline and 3 years later, whilst CT+PE had additional annual assessments. According to the results, the 3Y CT+PE outperformed control in cognitive abilities ( p < 0.002), and Activities of Daily Living (ADL) ( p < 0.001), stabilized their functional performances between 1st and 2nd year, but worsened in working and verbal memory between 2nd and 3 rd year ( p < 0.002). Control deteriorated in cognitive functions ( p < 0.001) and ADL ( p < 0.001) after 3 years, whilst 1.33% of the experimental and 13.53% of the control group progressed to dementia ( p < 0.001). Longitudinal CT+PE improves cognitive performance and ADL in MCI and delay the progression to dementia.

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