P.332 Detection and characterization of hepatitis E virus RNA in three fulminant hepatic failure cases in children in Argentina

Munné, María Silvina; Vladimirsky, Sara; Otegui, Lucio; Brajterman, Leonardo; Castro, Raúl; Soto, Solange; Moreiro, Rita; Ciocca, Mirta; Cuarterolo, Miriam; Sasbón, Jorge S.; Buamscha, Daniel; Giannivelli, Silvina; Schlauder, George G.; González, Jorge

doi:10.1016/s1386-6532(06)80506-8

Cited by 5 publications

(8 citation statements)

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“…Genotype 1 extensively circulates in Asia (including India, 75 – 78 Pakistan, 79 Nepal, 80 , 81 Bangladesh, 82 China, 49 , 83 – 85 Kyrgyzstan, 86 and Uzbekistan 87 and Africa (including Egypt, 88 Algeria, 89 Morocco, 87 Namibia, 90 Sudan, 91 and Chad 91 , 92 ), whereas genotype 2 has been isolated only in Mexico 93 and in some African countries (Nigeria, 94 Namibia, 95 Chad, 91 and Sudan 91 . Genotype 3 has been detected worldwide (America, 13 , 26 , 32 , 33 , 96 – 99 Europe, 9 , 10 , 12 , 15 , 16 , 18 , 20 , 21 , 27 , 34 , 35 , 100 – 102 Asia, 25 , 33 , 37 , 39 , 40 , 103 – 111 Australia, 69 and New Zealand 11 with the exception of Africa, whereas genotype 4 is restricted to India 112 , 113 and East Asia. 39 , 84 , 103 , 114 – 118 …”

Section: Epidemiologymentioning

confidence: 99%

“… 164 , 239 , 246 – 249 In this setting, HEV adversely affects both pregnant women and foetal outcome, with high mortality rate, increased frequency of abortions, preterm delivery, stillbirth, and neonatal death. 23 , 99 , 148 , 150 , 239 , 250 …”

Section: Clinical Featuresmentioning

confidence: 99%

“… 119 In Argentina, a country not endemic for hepatitis E, fulminant hepatitis has been recently diagnosed in three children infected with HEV genotype 3. 99 …”

Section: Clinical Featuresmentioning

confidence: 99%

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Hepatitis E: a complex and global disease

Pelosi

Clarke

2008

EHTJ

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Thirty years after its discovery, the hepatitis E virus (HEV) continues to represent a major public health problem in developing countries. In developed countries, it has emerged as a significant cause of non-travel-associated acute hepatitis. HEV infects a wide range of mammalian species and a key reservoir worldwide appears to be swine. Genomic sequence similarity between some human HEV genotypes and swine HEV strains has been identified and we know that humans can acquire HEV infection from animals. Although for the most part the clinical course of HEV infection is asymptomatic or mild, significant risk of serious disease exists in pregnant women and those with chronic liver disease. In addition, there are data on the threat of chronic infections in immunocompromised patients. Beyond management of exposure by public health measures, recent data support that active immunisation can prevent hepatitis E, highlighting the need for vaccination programmes. Here we review the current knowledge on HEV, its epidemiology, and the management and prevention of human disease.

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Section: Epidemiologymentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

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Hepatitis E: a complex and global disease

Pelosi

Clarke

2008

EHTJ

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“…Kumar et al [2006] described co-infection with multiple viruses in 30 (24.6%) children up to 15 years old with acute viral hepatitis being co-infection HAV/ HEV in 24 (80%). Also, HEV have been reported as etiological agent associated with acute liver failure in children [Munné et al, 2006].…”

Section: Discussionmentioning

confidence: 99%

Dual infection with hepatitis A and E viruses in outbreaks and in sporadic clinical cases: Cuba 1998–2003

Lay

Quintana

Villalba

et al. 2008

Journal of Medical Virology

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Viral hepatitis ranks as the fifth cause of morbidity for infectious diseases in Cuba. Epidemics are observed frequently in the population, the hepatitis A virus being the main agent responsible for such epidemics. Previous reports also confirmed the circulation of the hepatitis E virus. From 1998 to 2003, 258 serum samples were collected by the Reference Laboratory on Viral Hepatitis during 33 outbreaks of acute viral hepatitis as well as from 39 sporadic clinical cases. Sera were tested for anti-HAV and anti-HEV IgM by EIA. Overall of the 33 outbreaks studied sera from 12 (36.4%) were positive for anti-HAV IgM only, from 7 (21.2%) were positive for anti-HEV IgM only, and from 14 (42.4%) were positive for antibodies to both viruses. Individually of the 258 sera collected, 137 (53.1%) were positives for anti-HAV IgM, 20 (7.8%) were positives for anti-HEV IgM, 33 (12.8%) were positives for both markers and 68 (26.4%) were negative to both. Of the clinical cases, 4 (10.3%) were positives for anti-HAV IgM, 13 (33.3%) were positives for anti-HEV IgM and 5 (12.8%) were positives for both markers. Seventeen (43.6%) sera were negatives for all viral hepatitis markers available (A-E). A high positivity for HEV was found in outbreaks tested with the kit produced by CIGB. In particular HEV seems to infect individuals of all ages. The results demonstrate the co-circulation of and co-infection with two enterically transmitted viruses; however a higher positivity was observed for anti-HAV than to anti-HEV (53.1% vs. 7.8%) in outbreaks.

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“…The clinical features include jaundice, fever, flu-like symptoms, abdominal pain, vomiting, anorexia, and hepatomegaly (1,15,17). A minority of children may develop ALF, especially those with pre-existing chronic liver disease (36)(37)(38)(39). Two large pediatric series from India, in which genotype 1 is highly endemic, reported HEV or hepatitis A virus and HEV coinfection as the main causes of ALF or acute decompensation of underlying chronic liver disease (36,37).…”

Section: How and When Should Children Be Tested For Evidence Of Hev I...mentioning

confidence: 99%