P(BA-co-HBA) Coated Fe₃O₄@ZnO Nanoparticles as Photo-Responsive Multifunctional Drug Delivery Systems for Safer Cancer Therapy

Abstract

Amphipathic polymer coated magnetic nanoparticles which are loaded with docetaxel as photoresponsive multifunctional drug delivery systems for safer cancer therapy have been fabricated. Such kind of drug delivery system not only possesses favorable magnetic response property, but also could realize docetaxel-release and EGF-adsorption simultaneously simulated by UV and dark control, which can signi¯cantly boost the e®ectiveness of chemotherapy.

Progress and prospects of magnetic iron oxide nanoparticles in biomedical applications: A review

“…In general, natural polymer coatings help to avoid aggregation, and enhancing the hydrophilicity, stability, and biocompatibility, which lead to increased blood circulation time—thus improving bioavailability. The synthetic polymers affect the physicochemical properties and impart new characteristics such as thermosensitivity when using polymethylmethacrylate (PMMA) 87–91 …”

“…The synthetic polymers affect the physicochemical properties and impart new characteristics such as thermosensitivity when using polymethylmethacrylate (PMMA). [87][88][89][90][91] It is well recognized that surface charge, size and coating materials influence the characteristics of the protein absorption on the surface of SPIONs. Sakulkhu et al applied two different polymers-polyvinyl alcohol (PVA) and dextranfor coating the SPIONs with different surface charges.…”

UVA-Triggered Drug Release and Photo-Protection of Skin

“…Upon stimulation with UV irradiation, the chemical structure of ZnO was rearranged to release docetaxel and EGF, resulting in obstruction of the growth of cancer cells (Huang et al, 2015 ). In further research, they designed a photo-responsive multifunctional drug delivery by combining Fe 3 O 4 @ZnO core-shell and amphipathic polymer of P(BA-co-HBA)-loaded docetaxel which was able to boost chemotherapy effects by UV stimulation to trigger the ZnO hydrophilic / hydrophobic transition to release the drug and to prompt the amphipathic polymer to adsorb and encapsulate EGF (Huang et al, 2016 ). Later, Kong et al ( 2017 ) used the same multifunctional DDS to decrease the growth of skin cancer by giving a low dose of UV to release docetaxel and absorb EGF.…”

“…Later, Kong et al ( 2017 ) used the same multifunctional DDS to decrease the growth of skin cancer by giving a low dose of UV to release docetaxel and absorb EGF. A study from Huang et al ( 2016 ) also demonstrated that UV-mediated drug release would be able to control docetaxol release with simultaneous EGF adsorption resulting in reduced proliferation and metastasis of cancer cells.…”