P0405 Screening of Saudi Children With Short Stature for Celiac Disease

Saadah, Omar I.; Agha, Adnan; Albokhari, Shatha M.; Mughales, J. A. Al

doi:10.1097/00005176-200406001-00529

Cited by 4 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The included 16 studies were published between 2004 and 2018, covering a long period from 1990 until 2014, with 5 retrospective studies without year limitation 9-11,19,22…”

Section: Resultsmentioning

confidence: 99%

Celiac disease among at-risk individuals in Saudi Arabia

Safi

2019

SMJ

View full text Add to dashboard Cite

Objectives: To perform a meta-analysis for celiac diseases (CD) among at-risk populations in Kingdom of Saudi Arabia (KSA), as well as a comparison with our previously reported meta-analysis in the normal population. Methods: In March 2018, at King Abdulaziz University, Jeddah, KSA we commenced a retrospective comprehensive database and journal search for CD among at-risk populations in SA. Data from each of the relevant articles were analyzed using the Statistical Package for Social Science Version 20 (Armonk, NY: IBM Corp.). and the comprehensive meta-analysis program (CMA). The collected data were part of a retrospective literature review and analysis. Thus, a written ethical approval was not obtained before commencing the study. Results: Sixteen articles were found covering type-1 diabetes mellitus (DM), short stature (SS), and down syndrome (DS). Ages 1-50 years. The prevalence of seropositive-CD was 15.6% with high heterogeneity (I 2 =80.353), while prevalence of biopsy-proven CD was 10.6% with high heterogeneity (I 2 =73.359). Another article reported the CD prevalence in the at-risk population as 18.4% for the seroprevalence and 6.9% for the biopsy-proven CD. Anti-transglutaminase (anti-tTG) was used in 12 studies; in the remaining 4 studies (EMA in 2, ARA with AGA in one and no details given in one study). Conclusion: Both the prevalence of biopsy-proven CD (10.6%) and seroprevalence (15.6%) were higher than those we previously reported in the normal population (1.4% and 2.7%). The female-to-male ratio (1.9/1) of CD patients was the same in normal and at-risk populations in SA. Meta-analysis for prevalence of CD in DM, SS, and DS separately in SA is recommended.

show abstract

“…The included 16 studies were published between 2004 and 2018, covering a long period from 1990 until 2014, with 5 retrospective studies without year limitation 9-11,19,22…”

Section: Resultsmentioning

confidence: 99%

Celiac disease among at-risk individuals in Saudi Arabia

Safi

2019

SMJ

View full text Add to dashboard Cite

show abstract

“…The sum of the included articles were 74 references (see references). The 74 references (articles) comprised of two groups: 57 PubMed references and 17 non-PubMed references [78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94]. The 57 PubMed references comprised three subgroups: 32 references of "pediatric and adult (and/or adolescents)" , 23 references of "adult with adolescents" and 2 animal references [76,77].…”

Section: Results Of the Selection Process (Inclusion/exclusion) Of The Pertinent Studiesmentioning

confidence: 99%

“…The 57 PubMed references comprised three subgroups: 32 references of "pediatric and adult (and/or adolescents)" , 23 references of "adult with adolescents" and 2 animal references [76,77]. The 17 non-PubMed references comprised of three subgroups: 10 "pediatric with adults (and/or adolescents)" [78][79][80][81][82][83][84][85][86][87], 4 "adult with adolescents" [88][89][90][91] and three "pediatric" [92][93][94]. References in each subgroup were arranged (in the reference section) in a descending chronological order.…”

Section: Results Of the Selection Process (Inclusion/exclusion) Of The Pertinent Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Celiac Disease and its Serological Pattern in Saudi Arabia: A Systematic Review

Safi¹,

Safi²

2018

Glob Vaccines Immunol

View full text Add to dashboard Cite

Aim:To analyze the status of Celiac Disease (CD) and its Serological Pattern in Saudi Arabia (SA).Methods: Using a retrospective systematic literature review, the status of CD in SA was analyzed from various aspects. The related articles (74) were retrieved by database and journal search. Data were analyzed using the statistical package for social science (SPSS Inc). Results:The retrieved studies mostly represent multi heterogeneity in terms of journals (42 journal), centers (23 center), mode (12 type), fields (21 discipline). Most publications were found in: Saudi Medical Journal (12 articles), King Saud University, Riyadh (21), cross sectional (18), retrospective (18), Case report (18), Diabetes mellitus(T1DM) (8); while down syndrome (DS), short status (SS), skeletal health and CD prevalence had 3, 5, 6 and 7 articles respectively. Female to male ratio was 1.95/1. Histological evaluation was introduced early1980s followed by serology in 1990s. Biopsy showed the highest usage (in 57 studies), endomysial-antibody (EMA) (34), tissue-transglutaminase-antibodies (tTG-Ab) (29), anti-gluten-antibodies (AGA) ( 18), anti-reticulin-antibodies (ARA) (10). Publications started in 1990 with stable annual number (1-3) until it peaked (10 articles), in 2012, 2016 and 2017. Conclusion:The current study represents the first and only Systematic Review concerning the status of CD in SA and its serological pattern. We found one review evaluating skeletal health in CD in SA and one Meta-analysis concerning polymorphism association with CD, but no meta-analysis were found concerning the relationship between CD and other conditions such as T1DM, SS, DS and CD prevalence in SA, which will be our plan for separate publications.

show abstract

“…Of the five included studies in the above review, only one study was included in our review 29 . Three of the studies were excluded as the number of patients subjected to the screening of CeD was unclear, 46–48 and one study was only an abstract 53 . Also, no quality assessment of the included studies was performed.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Singh

Farooqui

et al. 2020

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and AimShort stature is a common extraintestinal manifestation of celiac disease (CeD). We conducted a systematic review and meta‐analysis to assess the global prevalence of CeD in patients presenting with short stature.MethodsWe searched Medline and EMBASE databases for the keywords “celiac disease, coeliac disease, anti‐gliadin, tissue transglutaminase antibody, anti‐endomysial antibody, short stature and growth retardation.” All the studies published from January 1991 to May 2020 were included. Patients without any prior evaluation for short stature were classified as all‐cause short stature, while prior evaluated patients, where no cause was found for short stature, were classified as idiopathic short stature. The diagnosis of CeD was based on the European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines. A random‐effects model was used to pool the data.ResultsSeventeen studies screening 3759 patients (1582 with all‐cause short stature and 2177 with idiopathic short stature) were included. The pooled seroprevalence of CeD based on positive anti‐tissue transglutaminase antibody and anti‐endomysial antibody was 11.2% (95% CI 4.0–21.2%; I2 = 86%) and 9.7% (95% CI 2.7–20.2%; I2 = 95%) for all‐cause and idiopathic short stature, respectively. Similarly, pooled prevalence of biopsy‐confirmed CeD was 7.4% (95% CI 4.7–10.6%; I2 = 76%) and 11.6% (95% CI 4.1–22.2%; I2 = 97%), for all‐cause and idiopathic short stature, respectively. There was an overall severe risk of selection bias and significant heterogeneity in the pooled results.ConclusionsApproximately one in 14 patients with all‐cause short stature and one in nine patients with idiopathic short stature had biopsy‐confirmed CeD. Therefore, evaluation for CeD may be prudent in all patients with short stature.

show abstract

P0405 Screening of Saudi Children With Short Stature for Celiac Disease

Cited by 4 publications

References 0 publications

Celiac disease among at-risk individuals in Saudi Arabia

Celiac disease among at-risk individuals in Saudi Arabia

Celiac Disease and its Serological Pattern in Saudi Arabia: A Systematic Review

Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Contact Info

Product

Resources

About