P181 Effects of autologous platelet-rich plasma on the metabolism of human articular chondrocytes

Nakagawa, Keisuke; Sasho, Takahisa; Arai, Michitsugu; Kitahara, S; Ogino, S.; Wada, Yoh; Moriya, H.

doi:10.1016/s1063-4584(07)61536-2

Cited by 18 publications

(8 citation statements)

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“…Nakagawa et al 45 reported the in vitro efficacy of autologous PRP in stimulating the proliferation and collagen synthesis of human chondrocytes, suggesting the use of this method in the treatment of cartilage defects.…”

Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis

et al. 2012

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Background:With increasing frequency, platelet-rich plasma (PRP) preparations have been used to treat cartilage lesions to regenerate tissue homeostasis and retard the progression of knee osteoarthritis (OA).Purpose:To determine the effectiveness of intra-articular PRP injections in active patients with knee OA and to evaluate clinical outcomes in patients with and without previous surgical treatment for cartilage lesions.Study Design:Case series.Materials and Methods:Fifty patients with knee OA were followed for a minimum of 12 months. All were treated with 2 intra-articular injections of autologous PRP. Twenty-five patients had undergone a previous operative intervention for cartilage lesions, whereas 25 had not. Operated patients had undergone either cartilage shaving or microfracture. Multiple evaluative scores were collected at pretreatment and at 6 and 12 months posttreatment. The required sample of patients was determined beforehand by using statistical power analysis; International Knee Documentation Committee (subjective) score was defined as the primary parameter. A P value of less than 0.05 was considered statistically significant. General linear model–repeated measure test evaluated within-time improvement for each variable for all patients. Post hoc test with Bonferroni adjustment for multiple comparisons was performed to investigate the significance in improvement within time evaluations for each variable for the total sample. The differences in improvement between operated and nonoperated patients were also investigated, as were those between sexes.Results:All patients showed significant improvement in all scores at 6 and 12 months (P < 0.01) and returned to previous activities. No significant difference in improvement was found between the evaluated subgroups (P < 0.01).Conclusions:The PRP treatment showed positive effects in patients with knee OA. Operated and nonoperated patients showed significant improvement by means of diminishing pain and improved symptoms and quality of life.Clinical Relevance:There are only a few studies of PRP treatment for cartilage on osteoarthritic knees. Different PRP products might be more or less appropriate to treat different types of tissues and pathologies. The clinical efficacy of PRP remains under debate, and a standardized protocol has not yet been established.

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Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis

et al. 2012

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“…Nakagawa et al in their in-vitro study showed the efficacy of autologous PRP in cell proliferation and collagen synthesis of human chondrocytes and suggested a new method of osteoarthritis treatment and use of this method in the treatment of cartilage defects in human (27).…”

Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Injection for Symptomatic Knee Osteoarthritis

et al. 2015

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Background: Platelet-rich plasma (PRP) is plasma of enriched platelets with high concentration of platelet granules and growth factors. The platelet growth factors have a great potential of wound and connective tissue healing used to treat cartilage lesions and retarding the progression of knee osteoarthritis. Objectives: This study was designed to evaluate PRP injection results in knee osteoarthritis. Patients and Methods:This was a case-series study of 39 patients and all of them had three injections of PRP for the involved knee (every two weeks) and they were followed up at two weeks, two months and six months post-injection of PRP. All included patients filled the WOMAC (western Ontario and Mcmaster universities arthritis index) standardized and translated to our national language and culture. We analyzed the collected scores of before initiation of PRP injections, the second week, the second month and the sixth month after injections into the knees. Results: Thirty-nine patients with a mean age of 55.24 ± 9.27 years (ranged 40 to 83) were evaluated in this study. Six patients (15.4%) were male and 33 patients (84.6%) female. There were significant differences in WOMAC score of patients in two months and six months after injection of PRP compared to before injection. Conclusions: PRP had a great clinical improvement in short-term follow-up for early stages of knee osteoarthritis.

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“…In vitro study, Nakagawa et al . 50 demonstrated increased chondrocytes proliferation and synthesis of collagen.…”

Section: Clinical Use Of Platelet-rich Plasmamentioning

confidence: 99%

Use of intraarticular injections of platelet-rich plasma in the treatment of knee osteoarthritis: A review article

Baloch¹,

Hasan²,

Baig³

et al. 2019

Orthop Rev (Pavia)

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Osteoarthritis is one of the most common degenerative conditions affecting knee joint. As our understanding in the disease pathogenesis is evolving, so do the treatment modalities. One of the postulated mechanisms suggests the production of inflammatory cytokines secondary to repeated micro trauma than in turn lead to cartilage damage overtime. Cartilage being avascular structure has limited potential for repair. Based on this, recent studies have been focusing on stimulating cartilage-healing process by growth factors. This is where platelet-rich plasma comes in to light. Literature is showing promising results of platelet-rich plasma in treating knee osteoarthritis. In this review we have discussed the preparation, composition, classification, uses of platelet-rich plasma as well as evidence for its efficacy and complications.

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P181 Effects of autologous platelet-rich plasma on the metabolism of human articular chondrocytes

Cited by 18 publications

References 0 publications

Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis

Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis

Platelet-Rich Plasma Injection for Symptomatic Knee Osteoarthritis

Use of intraarticular injections of platelet-rich plasma in the treatment of knee osteoarthritis: A review article

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