P3‐171: Characteristics of Early Onset Dementia in a Hospital Setting From Romania

Dumitru, M.M.; Chiriță, Vasile; Chiriță, Roxana

doi:10.1016/j.jalz.2014.05.1261

Cited by 2 publications

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“…Pharmacological therapies may be more beneficial for AD patients if they target mechanisms that become abnormal at the very beginning of the course of the disease when symptoms are minimal. A great challenge would be to identify standard practical biomarkers that can detect these early changes—biomarkers that could become available for current clinical practice and wider use [ 43 , 44 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…Indirect scientific evidence for this correlation was tested in different study designs when investigating the effects of vitamin D supplementation on cognitive outcomes in elderly individuals. There is no clear notion of when vitamin D (natural or administered as a supplement) is most effective in the pathogenesis of cognitive decline, particularly in AD; the pre-existing neurological insult could have been the reason for the failure of introducing such therapy too late or in insufficient doses [ 32 , 51 , 54 , 59 ]. Overall, conflicting evidence is provided by studies, which found that vitamin D supplementation neither improved cognitive outcomes nor reduced the risk of dementia or MCI compared to the controls.…”

Section: Discussionmentioning

confidence: 99%

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Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia

et al. 2022

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(1) Background: As dementia is an incurable, multifactorial neurodegenerative disease, we gathered and analyzed a number of patient characteristics, assessing possible correlations that may support early diagnosis and a more accurate prognosis for cognitively impaired patients. (2) Methods: We used standard clinical parameters (cognitive and functional status, comorbidities, and plasma vitamin D levels) in a study group of 162 patients aged above 55 years old. (3) Results: We reported a higher incidence of cardiovascular and metabolic comorbidities in patients with severe or moderate cognitive impairment; a validated correlation between functional status, cognitive status, and serum vitamin D levels; and a more frequently associated profile of neurologic comorbidities in patients with a more significant cognitive deficiency. (4) Conclusions: The present research adds data on the significant correlations of cognitive deficits with cardiovascular, metabolic, and neurologic diseases (and the lack of correlation with osteoarticular illness). Clinicians should make the best use of the current screening and assessment tools (such as the functional scoring of daily activities, cognitive evaluation, and the screening of risk factors). Our data may offer starting points for future in-depth analysis of dementia-modifiable risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia

et al. 2022

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An Integrative Literature Review on the Nomenclature and Definition of Dementia at a Young Age

Veen

Bakker

Peetoom

et al. 2021

JAD

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Background: There has been growing interest in young people living with dementia. Future research requires consensus on the terminology and operational definition of this group. Objective: The purpose of this integrative review was to explore and include all operational definitions used to define dementia at a young age. Methods: On August 14, 2020, the PubMed, Embase, Cinahl, and PsycInfo databases were searched for empirical and theoretical literature using Google. Various terms to describe and define ‘dementia’ and ‘at a young age’ were used to collect literature concerning terminology; age-related aspects, including cut-off ages and criteria; and etiologies of dementia at a young age. Results: The search yielded 6,891 empirical and 4,660 theoretical publications, resulting in the inclusion of 89 publications, including 36 publications containing an explicit discussion and 53 publications as confirmation. ‘Young-onset dementia’ was the most commonly used term of seven identified terms, in the last two decades. The age of 65 years at symptom onset was used most frequently when considering a total of six upper age limits and four criteria to define a cut-off age. Eight lower age limits and an option for subdivision based on age were included. We identified 251 different etiologies and 27 categories of etiologies. Conclusion: Despite relative consensus on the term young-onset dementia and an age at symptom onset being used as a cut-off criterion, much is still unclear concerning possible etiologies of dementia at a young age. In the current study, controversies were detected for discussion in an international consensus study.

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P3‐171: Characteristics of Early Onset Dementia in a Hospital Setting From Romania

Cited by 2 publications

References 0 publications

Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia

Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia

An Integrative Literature Review on the Nomenclature and Definition of Dementia at a Young Age

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