P3.91. Reassessment of risk factors for oral cancer

Gangane, Nitin; Grover, Sahil; Gupta, Anupama; Gupta, Sahil

doi:10.1016/j.oos.2009.06.617

Cited by 21 publications

(34 citation statements)

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“…However, Gangane et al (2007) and Saraswathi et al (2006) reported majority of oral malignancies in the 50 to 59 years age group and 40 to 61 years age group respectively. 6,16 Thus, proving OSCC to be common in older adults.…”

Section: 14mentioning

confidence: 99%

“…However, recently the incidence of oral cancer in younger age group is increasing due to easy availability of gutkas and pan masalas which are packed appealingly to the present generation. 6,7 Various classification systems have been proposed to categorize OSCC and the treatment planning is based on them. Treatment is usually in the form of surgery, chemotherapy and radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Demographics and Histopathological Patterns of Oral Squamous Cell Carcinoma at a Tertiary Level Referral Hospital in Hyderabad, India: A 5-Year Retrospective Study

Grover¹,

Shyam²,

Rao³

et al. 2012

JOFR

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Section: 14mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Demographics and Histopathological Patterns of Oral Squamous Cell Carcinoma at a Tertiary Level Referral Hospital in Hyderabad, India: A 5-Year Retrospective Study

Grover¹,

Shyam²,

Rao³

et al. 2012

JOFR

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“…Squamous cell carcinomas (SCCs) comprise 90% of head-and-neck cancers (2). High consumption of alcohol and/or tobacco (3,4) and viral infections [e.g., human papilloma virus (HPV)] (5,6) represent two major risk factors for the development of head-and-neck SCC. Although the appropriate primary prevention measures, such as change of lifestyle or vaccination against HPV, already exist, not all cases of SCC can be prevented (7,8).…”

Section: Introductionmentioning

confidence: 99%

Expression patterns of CD168 correlate with the stage and grade of squamous cell carcinoma of head and neck

Jöhrens

Anagnostopoulos

Dommerich

et al. 2017

Molecular and Clinical Oncology

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Abstract. The receptor for hyaluronan-mediated motility CD168 is associated with the processes of oncogenesis and metastasis. The objective of the present study was to determine the possible association between the expression and distribution of CD168 and the tumor stage of head-and-neck squamous cell carcinoma (SCC). Formalin-fixed and paraffinembedded tumor samples obtained from 100 patients during primary resection of SCC from the oral cavity, oropharynx, hypopharynx or larynx were included in the present study. The patients were divided into two risk groups: Low risk, representing the early stage of completely resected SCCs with good-to-moderate differentiation, and the high-risk group, representing the advanced stage SCCs with positive resection margins, vascular invasion or locoregional metastasis. All specimens were stained with a monoclonal antibody against CD168. Percentage and staining intensity of CD168-positive cells were scored, and their spatial distribution within the tumor nests was noted. The results obtained were correlated with the tumor stage. The quantification of CD168 expression revealed significant differences between the two risk groups (t-test, P=0.002), with higher scores in tumors resected from the highrisk SSC group compared with those from the low-risk group. In addition, in the high-risk group, the CD168-positive cells were present predominantly in the periphery (70.4%) of tumor nests, whereas in the low-risk group, only 56.6% were located there; however, this trend did not reach the level of statistical significance. Taken together, the results from the present study suggested that CD168 expression patterns could potentially be used as a predictor of tumor aggressiveness, and therefore they may be a prognostic factor in head-and-neck SCC.

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“…In experimental models, the ingredients from the quids have demonstrated induction of cellular and molecular changes, including the generation of reactive oxygen species (ROS) and DNA damage in the hamster pouch model [3,4]. In a study conducted on 140 patients, with age-and sex-matched controls, with oral cancers from Central India, tobacco use, smoking and alcohol consumption emerged as contributing factors that act in a synergistic fashion in the induction of oral neoplasia [5]. Furthermore, multi-step oral epithelial carcinogenesis models induced in the laboratory employing systematic genetic alterations clearly indicated that in addition to changes in cyclin D1 and p53, c-Myc expression along with the acquisition of telomerase activity was pivotal for neoplastic transformation of these tumours [6].…”

Section: Introductionmentioning

confidence: 99%

Over-expression of c-Myc oncoprotein in oral squamous cell carcinoma

Pai¹,

Pai²,

Lalitha³

et al. 2009

ecancer

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Oral neoplasm constitutes a predominant class of cancer that is encountered in South India. This is in large part due to the elevated risk of oncogenesis as a result of the habit of chewing of quids containing betel leaves, areca nut and smokeless tobacco. An array of molecular events are induced during the transformation of the buccal epithelium, among them the over-expression of oncogene products plays a key role. The c-Myc protein, a regulator of a number of key cellular signalling pathways, plays a pivotal role in a number of malignancies. The present study was undertaken to evaluate expression of the c-Myc protein in tumours of the oral cavity from the South Indian population, predominantly oral squamous cell carcinoma (OSCC). The c-Myc protein was over-expressed in 80% of the cases studied. Taking into account the pivotal role demonstrated for c-Myc in tumourigenesis, our observations suggest a key role for Myc oncoprotein in the genesis of OSCC as well as its potential as a therapeutic target in this population.

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P3.91. Reassessment of risk factors for oral cancer

Cited by 21 publications

References 0 publications

Demographics and Histopathological Patterns of Oral Squamous Cell Carcinoma at a Tertiary Level Referral Hospital in Hyderabad, India: A 5-Year Retrospective Study

Demographics and Histopathological Patterns of Oral Squamous Cell Carcinoma at a Tertiary Level Referral Hospital in Hyderabad, India: A 5-Year Retrospective Study

Expression patterns of CD168 correlate with the stage and grade of squamous cell carcinoma of head and neck

Over-expression of c-Myc oncoprotein in oral squamous cell carcinoma

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