P4‐034: Stress as a Risk Factor in Induction and Progression of Alzheimer’s Disease: Impact on the Possible Protection Using Epigallocatechin‐3‐Gallate and/or Diazepam

Ali, Azza A.; Ahmed, Hebatalla I.; Zaky, Heba S.

doi:10.1016/j.jalz.2016.06.2123

Cited by 4 publications

(6 citation statements)

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“…This study was supported by Said and Rabo (2017) that Al can cause hemorrhagic and congestion of blood vessels in the cerebral cortex. The research was also supported by Ali et al (2016) that Al can cause hemorrhagic with edema in the meninges, which is related to congestion of blood vessels in the cerebral cortex. In this study that congestion and haemorrhage on the cerebral cortex of mice at the Al-treatment group one month, two months and three months of aged, it is suspected that the accumulation of Al affects the permeability of blood vessels, changing them from being semipermeable to permeable against Al.…”

Section: Methods Resultsmentioning

confidence: 77%

Effect of aluminum chloride against changes of the histological structure of the cerebral cortex of mice (swiss webster)

Irnidayanti

Aprilyanti

2021

Berkala Penelitian Hayati

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The toxicity of metal to living organisms, including human beings, was discovered a long time ago. In the present time, aluminum exposure is widely used for wrapping food to keep it taste and smell. However it will affect to human health security, specially the brain. This study aimed to investigate the changes of histological Structure on the cerebral cortex caused by aluminum chloride. The mice were injected intraperitoneally with AlCl3 200 mg per kg body weight, once every 3 days, totalizing 10 administrations. Control only was administration distilled water. Histological observations were carried out using the paraffin method. The results of this study show that aluminum chloride cause disorganization of the laminated cerebral cortex, vacuolization, karyolysis, congestion, and hemorrhage. The mice of one and two-months of age group were more susceptible to aluminum chloride than the mice of the three-months of age group. This research can apply for an assessment of the exposure risk to heavy metal. Increasing Al contamination can occur naturally or by anthropogenic activities. The accumulation of the heavy metal in the organism can occur by biomagnification, by which heavy metal is passed from one trophic level to the next within a food web. Therefore communities that live in urban areas potentially exposed to metals aluminum and should be more concerned related to understanding health risks. Further studies are needed to examine the

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Section: Methods Resultsmentioning

confidence: 77%

Effect of aluminum chloride against changes of the histological structure of the cerebral cortex of mice (swiss webster)

Irnidayanti

Aprilyanti

2021

Berkala Penelitian Hayati

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“…Cognitive engagement, physical activities [62], reduce stress [23], quitting or reducing smoking, avoid excessive alcohol consumption have been associated with decreased risk of AD. Healthy food as well as dietary supplementation of antioxidants, B vitamins, polyphenols, polyunsaturated fatty acids, Zinc and moderate coffee drinking can reduce AD incidence and provide protection.…”

Section: Resultsmentioning

confidence: 99%

“…These strategies include the use of the combined treatments or the protective agents together with socialization as well as programs of both physical and mental activities. In animal experimental models, multi-target directed strategies showed promising results and provided protection especially in the presence of different risk factors as stress, isolation and protein malnutrition [23,24,61]. For example, EGCG is effective in minimizing the hazards of aluminum-induced AD in rats; however the combined therapy of Epigallocatechin-3-gallate (EGCG) and coenzyme Q10 (CoQ10) or EGCG and vitamin E and selenium has more pronounced protective effects than EGCG alone [4, 24,63].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, coadministration of moderate doses of both caffeine and nicotine can reduce the risk of neuronal degeneration and attenuate the impairment of memory than each of them alone [64]. In addition, the deleterious effect of stress on the brain can be also counteracted by using EGCG together with Diazepam [23].…”

Section: Resultsmentioning

confidence: 99%

“…The exact cause for this relationship is unknown but it is postulated that formation of more synaptic connections is considered as a synaptic reserve in the brain and occurs in people with higher education level, thus enabling them to compensate the loss of neurons as the AD progresses [22]. Exposure to stress represents a risk factor in induction of AD especially in the developed countries, while protein malnutrition (PM) which increases the severity and progression of AD represents socioeconomic problem in the third world and developing countries [23,24]. On the other hand, researchers believe that depression is a risk factor, whereas others believe it may be an early symptom of the disease.…”

Section: Resultsmentioning

confidence: 99%

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Risk Factors in Induction and Progression of Alzheimer’s Disease: Impacton Protection and Disease-Modifying Factors

Ali¹

2017

Brain Disord Ther

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to memory loss and nerve cell death throughout the brain. It is the most common cause of dementia and represents the most important problem in elderly. Dementia characterized mainly by decline in memory, cognitive skills and ability to perform everyday activities as well as behavioral dysfunction. The decline occurs because neurons involved in cognitive function have been destroyed and affected other parts of the brain involved in different basic bodily functions.

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HPLC-PDA-MS/MS profiling of secondary metabolites from Opuntia ficus-indica cladode, peel and fruit pulp extracts and their antioxidant, neuroprotective effect in rats with aluminum chloride induced neurotoxicity

El‐Hawary

Sobeh

Badr

et al. 2020

Saudi Journal of Biological Sciences

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Opuntia ficus-indica (L.) Mill. (OFI), also known as Indian fig Opuntia or prickly pear, is a member of the family Cactaceae that produces edible, nutritionally rich sweet fruits. It has been traditionally used to treat several health disorders and is considered to possess various therapeutic properties. In this work, we have characterized 37 secondary metabolites using HPLC-MS/MS, identified the polysaccharide from the fruits and cladodes pulp , and estimated the neuroprotective activity . All tested extracts exhibited substantial antioxidant activities in-vitro and neuroprotective potential in AlCl 3 induced Alzheimer’s condition. Administration of OFI extracts attenuated AlCl 3 induced learning and memory impairment as confirmed from passive avoidance test and counteracted the oxidative stress as manifested from decreasein the elevated MDA level, increased TAC, GSH, SOD and CAT levels. OFI extracts significantly decreased the elevated brain levels of proinflammatory cytokines (NF-κβ and TNF-α), increased anti-inflammatory cytokine (IL-10), and monoamine neurotransmitters (NE, DA, 5-HT) as compared to positive control group. The extracts showed a significant decrease in acetylcholinesterase level (AChE) as compared with AlCl 3. Furthermore, molecular docking was performed to investigate the ability of the major constituents of OFI extracts to interact with acetylcholinesterase (AChE) and serotonin transporter (SERT). Among the tested extracts, cladodes contain highest phenolic content and exhibited the highest antioxidant, anti-inflammatory and neuroprotective activities, which could be attributed to presence of several polyphenols, which could function as AChE and SERT inhibitors. Opuntia ficus-indica might be promising candidate for treating Alzheimer disease, which makes it a subject for more detailed studies.

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P4‐034: Stress as a Risk Factor in Induction and Progression of Alzheimer’s Disease: Impact on the Possible Protection Using Epigallocatechin‐3‐Gallate and/or Diazepam

Cited by 4 publications

References 0 publications

Effect of aluminum chloride against changes of the histological structure of the cerebral cortex of mice (swiss webster)

Effect of aluminum chloride against changes of the histological structure of the cerebral cortex of mice (swiss webster)

Risk Factors in Induction and Progression of Alzheimer’s Disease: Impacton Protection and Disease-Modifying Factors

HPLC-PDA-MS/MS profiling of secondary metabolites from Opuntia ficus-indica cladode, peel and fruit pulp extracts and their antioxidant, neuroprotective effect in rats with aluminum chloride induced neurotoxicity

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