P61 Long-Lasting Analgesic Effect of Intra-Articular Injection of Cross-Linked Hyaluronate Gel (Gel-200) on Arthritic Pain

A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee

“…In comparison with PBS, a single injection of Gel-200 significantly decreased articular cartilage degeneration at 9 weeks after ACL transection and was more effective than five injections of non-cross-linked HA in the rabbit model. In rats with arthritis pain induced by bradykinin and silver nitrate, pain scores with Gel-200 administration were lower than those administered PBS or non-cross-linked HA 5,9,15 . Additionally, Gel-200 exhibited a longer analgesic effect compared with PBS in a monosodium urate induced joint inflammation model in dogs 16 .…”

“…Gel-200 is a sterile, transparent, viscoelastic hydrogel composed of cross-linked hyaluronate 8 , a derivative of a highly purified sodium hyaluronate product extracted from chicken combs. Noncross-linked HA diffuses out of the synovial fluid rapidly after administration into the knee joint, while injected Gel-200 was found to persist in synovial fluid for up to 7 days and synovium for as long as 28 days in rabbits without IA inflammation 9 . The effects of a single injection of Gel-200 have been compared with phosphate buffered saline (PBS) in an established experimental animal model of OA: unilateral transection of the anterior cruciate ligament (ACL) in rabbits 10À14 .…”