Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition

Li, Baoe; Xia, Xiaomei; Chen, Jiatian; Xia, Dan; Xu, Rui; Zou, Xianrui; Wang, Hongshui; Liang, Chunyong

doi:10.1088/1361-6528/abb55a

Cited by 32 publications

(18 citation statements)

References 42 publications

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“…The characteristic peak at 1424 cm − 1 corresponds to the bending vibration peak of -CH 2 , and 1142 and 851 cm − 1 are the characteristic peaks caused by C-C stretching vibration [ 27 , 28 ]. It can be seen that the characteristic peak of Van cannot be observed in PVA/Van, which may be due to the successful encapsulation of Van into the interior of fibers [ 29 ]. In the infrared peak of PVA/ZIF-8 and PVA/V@Z membranes, the characteristic absorption peaks of ZIF-8 at 1180, 752 and 684 cm − 1 can be observed, indicating the encapsulation of ZIF-8 and V@Z particles in them.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Vancomycin@ZIF-8 Loaded PVA Nanofiber Membrane for Infected Bone Repair

Zhao

Wang

Zou

et al. 2022

IJMS

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Bone substitutes with strong antibacterial properties and bone regeneration effects have an inherent potential in the treatment of severe bone tissue infections, such as osteomyelitis. In this study, vancomycin (Van) was loaded into zeolitic imidazolate framework-8 (ZIF-8) to prepare composite particles, which is abbreviated as V@Z. As a pH-responsive particle, ZIF-8 can be cleaved in the weak acid environment caused by bacterial infection to realize the effective release of drugs. Then, V@Z was loaded into polyvinyl alcohol (PVA) fiber by electrospinning to prepare PVA/V@Z composite bone filler. The drug-loading rate of V@Z was about 6.735%. The membranes exhibited super hydrophilicity, water absorption and pH-controlled Van release behavior. The properties of anti E. coli and S. aureus were studied under the pH conditions of normal physiological tissues and infected tissues (pH 7.4 and pH 6.5, respectively). It was found that the material had good surface antibacterial adhesion and antibacterial property. The PVA/V@Z membrane had the more prominent bacteria-killing effect compared with the same amount of single antibacterial agent containing membrane such as ZIF-8 or Van loaded PVA, and the antibacterial rate was up to 99%. The electrospun membrane had good biocompatibility and can promote MC3T3-E1 cell spreading on it.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Vancomycin@ZIF-8 Loaded PVA Nanofiber Membrane for Infected Bone Repair

Zhao

Wang

Zou

et al. 2022

IJMS

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“…Despite the extensive use of lignin-loaded nanodrug carriers alone, drug-loaded LNPs can also be encapsulated into nanofibers for efficient cervical cancer-cell inhibition, as suggested by Li et al [ 87 ]. In particular, the authors first loaded paclitaxel (model drug) into lignin nanoparticles and, subsequently, encapsulated, using the electrospinning technique, the paclitaxel-LNPs into a composite and biocompatible nanofibrous membrane that was composed of poly(vinyl alcohol)/polyvinyl pyrrolidone for drug-carrier purposes.…”

Section: Examples Of Lignin-based Nanoparticles For Drug Deliverymentioning

confidence: 99%

Lignin as a Natural Carrier for the Efficient Delivery of Bioactive Compounds: From Waste to Health

et al. 2022

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Lignin is a fascinating aromatic biopolymer with high valorization potentiality. Besides its extensive value in the biorefinery context, as a renewable source of aromatics lignin is currently under evaluation for its huge potential in biomedical applications. Besides the specific antioxidant and antimicrobial activities of lignin, that depend on its source and isolation procedure, remarkable progress has been made, over the last five years, in the isolation, functionalization and modification of lignin and lignin-derived compounds to use as carriers for biologically active substances. The aim of this review is to summarize the current state of the art in the field of lignin-based carrier systems, highlighting the most important results. Furthermore, the possibilities and constraints related to the physico–chemical properties of the lignin source will be reviewed herein as well as the modifications and processing required to make lignin suitable for the loading and release of active compounds.

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“…Cervical cancer has become a very serious problem, especially in developing countries, with incidence and mortality rates accounting for large proportions of the global cancer rate. 1 2 3 4 …”

Section: Introductionmentioning

confidence: 99%

Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors

et al. 2021

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Purpose Indocyanine green (ICG) is a promising agent for intraoperative visualization of tumor tissues and sentinel lymph nodes in early-stage gynecological cancer. However, it has some limitations, including a short half-life and poor solubility in aqueous solutions. This study aimed to enhance the efficacy of near-infrared (NIR) fluorescence imaging by overcoming the shortcomings of ICG using a nano-drug delivery system and improve target specificity in cervical cancer. Materials and Methods ICG and poly(lactic-co-glycolic acid) (PLGA) conjugated with polyethylenimine (PEI) were assembled to enhance stability. Hyaluronic acid (HA) was coated on PEI-PLGA-ICG nanoparticles to target CD44-positive cancer cells. The manufactured HA-ICG-PLGA nanoparticles (HINPs) were evaluated in vitro and in vivo on cervical cancer cells (SiHa; CD44+) and human dermal cells (ccd986sk; CD44-), respectively, using NIR imaging to compare intracellular uptake and to quantify the fluorescence intensities of cells and tumors. Results HINPs were confirmed to have a mean size of 200 nm and a zeta-potential of 33 mV using dynamic light scattering. The stability of the HINPs was confirmed at pH 5.0–8.0. Cytotoxicity assays, intracellular uptake assays, and cervical cancer xenograft models revealed that, compared to free ICG, the HINPs had significantly higher internalization by cervical cancer cells than normal cells ( p <0.001) and significantly higher accumulation in tumors ( p <0.001) via CD44 receptor-mediated endocytosis. Conclusion This study demonstrated the successful application of HINPs as nanocarriers for delivering ICG to CD44-positive cervical cancer, with improved efficacy in NIR fluorescence imaging.

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Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition

Cited by 32 publications

References 42 publications

Antibacterial Vancomycin@ZIF-8 Loaded PVA Nanofiber Membrane for Infected Bone Repair

Antibacterial Vancomycin@ZIF-8 Loaded PVA Nanofiber Membrane for Infected Bone Repair

Lignin as a Natural Carrier for the Efficient Delivery of Bioactive Compounds: From Waste to Health

Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors

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