Pagetoid dyskeratosis: A selective keratinocytic response

Giant angiofibromas in tuberous sclerosis complex: A possible role for localized lymphedema in their pathogenesis

“…This feature is often seen in histopathologic specimens obtained from the intertriginous areas, the perianal zone, vulva, and penis and is considered to represent a reactive process in which a small part of the normal population of keratinocytes is induced to proliferate, possibly by friction. [42][43][44] Rubbing of the lesions because of their large size is a likely explanation in our case. J AM ACAD DERMATOL VOLUME 67, NUMBER 6 It is known that patients with TSC2 alterations manifest a more severe phenotype than patients with TSC1.…”

Comparative Study of Pagetoid Dyskeratosis Between Acrochordons and Soft Fibromas

“…Special stains such as mucicarmin, alcian blue, PAS, colloidal iron, or Fontana-Masson silver procedure yield negative results. 1 Immunohistochemically, PD cells react strongly positive with high weight cytokeratin in contrast to the surrounding keratinocytes. 1 Other antibodies against S100 protein, carcinoembrionic antigen, and human paillomavirus yield negative results.…”

“…1 Immunohistochemically, PD cells react strongly positive with high weight cytokeratin in contrast to the surrounding keratinocytes. 1 Other antibodies against S100 protein, carcinoembrionic antigen, and human paillomavirus yield negative results. For EMA and low weight cytokeratin, the reaction is similar to the surrounding keratinocytes.…”

“…7,8 According to our experience, PD is more frequent in soft fibromas than in acrochordons. Thus, the purpose of this study is to confirm this view by (1) comparing the presence of PD in acrochrodon and soft fibroma and (2) comparing PD positive soft fibromas and PD negative soft fibromas.…”

“…1 Although PD is found in other settings, it seems to be the unique pathological finding in a few cases of patchy discoloration of the dorsal aspect of the hand or tips of the fingers. 7,8 According to our experience, PD is more frequent in soft fibromas than in acrochordons.…”