Painful digital infarction in a male smoker treated as Buerger's disease

Foley, Susan M.; Gibbs, Harry; Muir, James

doi:10.1111/j.1440-0960.2008.00432.x

Cited by 8 publications

(6 citation statements)

References 12 publications

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“…[1][2][3] The confusing etiopathogenesis of this disorder often makes it difficult to diagnose and treat. 3 The obstructed vessels with thrombi can be detected in microscopic scans, and thrombotic findings can be revealed in pathological examinations of the affected vessel sites. 4,5 Platelet activation and thrombotic events at affected sites of the vascular system are known to play a crucial role in cardiovascular disorders.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of mean platelet volume in thromboangiitis obliterans

et al. 2013

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Thromboangiitis obliterans (TAO) affects small- and medium-sized vessels of the extremities via a non-atherosclerotic inflammatory process in the elderly. Although diagnostic criteria have been determined, only a few studies have been described in the laboratory features. Diagnostic biomarkers are important for reducing disruptions caused by TAO. The diagnostic importance of mean platelet volume (MPV) was investigated in TAO patients. Forty-four patients diagnosed with TAO (study group) and 45 healthy individuals (control group) were included in the study. The age, gender and complete blood parameters obtained via peripheral venous blood samples were compared between the two groups. A receiver operating characteristic (ROC) curve was used for determining the diagnostic accuracy of the MPV variable. All the variables were statistically similar in each group except MPV and platelet counts. MPV was significantly higher and platelet count was significantly lower in the TAO group (P< 0.05). In addition, diagnostic accuracy was measured by the area under the ROC curve (Figure 1), and MPV differs significantly (P< 0.001), with a value of 0.783 (95% CI: 0.711-0.854). This study indicates that MPV is probably an important diagnostic predictor in TAO patients. Detection of blood parameters such as platelet properties is important for meticulous care of these patients.

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Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of mean platelet volume in thromboangiitis obliterans

et al. 2013

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“…Additionally 29 (97%) subjects had smoking history in TAO group and 22 (73%) in control group. TAO is diagnosed and treated with difficulty because of elusive etiology (10]. There is no sufficient knowledge about the other risk factors and predisposing conditions in the literature [11,12].…”

Section: Discussionmentioning

confidence: 99%

Association of the plasminogen activator inhibitor-1(PAI-1) gene 4G/5G promoter polymorphism in Buerger's disease (Tromboangiitis obliterans)

Manduz¹,

Katrancioglu²,

Karahan³

et al. 2010

Health

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Thromboangiitis obliterans (TAO) is an unusual tobacco-associated vasculopathy that is a non- atherosclerotic inflammatory disorder of unkn- own etiology that affects small and medium- sized vessels of the extremities. The single guanosine nucleotide deletion/insertion polym- orphism (4G/5G) at -675 bp in promoter region of the PAI-1 gene is the major genetic determi- nant of PAI-1 expression. Plasma PAI-1 level is higher in people with the homozygous 4G genotype than in those with the 5G/5G genotype and renders higher transcription activity. The aim of this study was to determine the status and the role of PAI-1 gene 4G/5G promoter polymorphism in patients with Buerger's disease (Thromboangiitis obliterans—TAO). The current case-control study included 30 consecutive pat- ients with Buerger's disease (mean age 42.9 ± 14.3 years, 28 men and 2 women), and 30 healthy volunteers (mean age 40.9 ± 4.79 years, 27 men and 3 women) between January 2006 and September 2009. Patients and control cases were genotyped for the 4G/5G polymorphism using the multiplex PCR based stripassay reverse hybridisation technique. It was found that heterozygote PAI-1 gene polymorphisms (p < 0.05) was significantly more frequent in patients with TAO in the current results. There was a significant difference in genotype distribution between the two groups (P < 0.001). The 4G allele occurred more frequently in the patient group of heavy smokers (P = 0.05). The current study shows the higher prevalence of of 4G allele in TAO patients in Sivas population means gene may predispose to TAO

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“…However, TAO patients may not benefit from Iloprost without also quitting smoking. [64][65][66] Cigarette smoking activates P-selectin expression by platelets and stimulates the CD40-CD40L pathway. CD40L of platelets interacts with endothelial CD40 and then mediates an array of proinflammatory effects, including the expression of cytokines, chemokines and adhesion molecules.…”

Section: Smoking and Plateletsmentioning

confidence: 99%

“…PGI2 analogs decrease arteriole spasm, endothelial selectin and vWF concentrations and inhibit platelet aggregation. [64][65][66] They also activate fibrinolysis and decrease reactive oxygen species (ROS) production. 119,120 Several clinical trial studies demonstrated that Iloprost administration is more effective than sympathectomy.…”

Section: Taos and Drug Targetsmentioning

confidence: 99%

A review on thromboangiitis obliterans pathophysiology: thrombosis and angiitis, which is to blame?

Fazeli¹,

Rezaee

2011

Vascular

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A century has passed since thromboangiitis obliterans (TAO), or Buerger's disease, was first described, but the etiology remains unclear. It is still uncertain as to whether thrombosis or vascular inflammation is the first event. TAO is an episodic inflammatory and thrombotic-occlusive vascular disease of unknown origin. The involvement of the distal vessels and nerves within the neuro-vascular bundles occurs almost always in legs and occasionally in arms. The cumulative data demonstrate that at the cellular and molecular levels, at least four main components of inflammatory reactions, including endothelial cells, platelets, leukocytes and sensory neurons, might be involved in TAO pathogenesis. The interactions among these cells in an altered microenvironment of small- and medium-sized vessels may also orchestrate the onset of TAO events. In this review, the factors that may promote thrombosis and angiitis are reconsidered at three levels: (1) host characteristics such as male gender and genetic background; (2) probable triggers including cigarette smoking and infectious agents; and (3) environmental factors such as chronic anxiety and mental stress as a consequence of low socioeconomic status. At each level, the interactions among vascular endothelium, platelets, leukocytes and sensory neurons are discussed.

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Painful digital infarction in a male smoker treated as Buerger's disease

Cited by 8 publications

References 12 publications

Diagnostic accuracy of mean platelet volume in thromboangiitis obliterans

Diagnostic accuracy of mean platelet volume in thromboangiitis obliterans

Association of the plasminogen activator inhibitor-1(PAI-1) gene 4G/5G promoter polymorphism in Buerger's disease (Tromboangiitis obliterans)

A review on thromboangiitis obliterans pathophysiology: thrombosis and angiitis, which is to blame?

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