Palladium(II) Pyridinecarboxaldimine Complexes Derived from Unsaturated Amines

Zhang, Haiwen; Enman, Jennifer E.; Conrad, Maren L.; Manning, Marcy J.; Turner, Courtney S.; Wheaton, Susan L.; Vogels, Christopher M.; Westcott, Stephen A.; Decken, Andreas; Baerlocher, Felix J.

doi:10.1007/s11243-005-6319-x

Cited by 8 publications

(1 citation statement)

References 41 publications

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“…[97] Compound 176 acts as a substrate for secondary reactivity and was also evaluated for antifungal potentials against A. niger, A. flavus, C. albicans and S. cerevisiae, where it was found to be prominent antifungal agent (Amphotericin B was used as standard in the study). [98] A series of nine lipophilic Pd complexes with iminopyridine derivatives were synthesized and tested for antimicrobial efficiency. [99] Most of the compounds were inactive against the tested strains, mechanistic study of these compounds is needed to know abot the reason of inefficiency, so that further research line is clarified.…”

Section: Coordination Compounds For Biological Applicationsmentioning

confidence: 99%

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Khan

2021

ChemistrySelect

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Pyridine (py) is an important heterocyclic compound and is an integral part of various natural products. There are various medicines containing py ring system being available in the market to combat different human ailments. Observing the medicine market, Omeprazole, a widely used py-based drug in medicinal market since 1998. Netupitant (an antiemitic drug, since 2014) is used in combination with another drug to prevent acute and delayed vomiting and nausea associated with cancer chemotherapy led the run towards development of anticancer drugs. Several drugs have been approved by FDA for the treatment of cancer in recent years such as, Abemaciclib (2015), Lorlatinib (2018), Apalutamide (2018) and Ivosidenib (2019). Research on py on the bases of these advancements is an evergreen field and associated with greater hopes to address several disease related issues. Several compounds are in the process of clinical trials and are expected to serve various purposes in days to come. This review article deals with recent findings in py chemistry and its coordination complexes. The medicinal efficiency has been argued for organic and inorganic derivatives. Selected biological applications are hereby discussed as follow up study of our report in 2015. Suitable literature prior to 2015 has also been incorporated in appropriate places in order to cover the scope in broader sense.

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Section: Coordination Compounds For Biological Applicationsmentioning

confidence: 99%