PAMAM Dendrimer Based Macromolecules as Improved Contrast Agents

Venditto, Vincent J.; Regino, Celeste A.S.; Brechbiel, Martin W.

doi:10.1021/mp050019e

Cited by 151 publications

(131 citation statements)

References 56 publications

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“…Consequently, a plethora of various natural and synthetic organic and inorganic nanomaterials differing in size, shape, structure, chemistry and architecture have been explored for use as MRI contrast agents [36][37][38][39]. Among the different nanosystems established for MRI, dendrimers are of particular interest because of their welldefined molecular structure and multivalent cooperativity confined within a nanosize volume [36,37,[40][41][42]. Den-drimers have a unique dendritic architecture with regular cascade-branched repeating units emanating from a focal point and abundant terminal groups on the surface (Fig.…”

Section: Mri Contrast Agents Based On Dendrimer Nanotechnologymentioning

confidence: 99%

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Dendrimer-based magnetic resonance imaging agents for brain cancer

et al. 2018

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Brain cancer is one of the most lethal and difficult-to-treat cancers because of its physical location and biological barriers. The mainstay of brain cancer treatment is surgical resection, which demands precise imaging for tumor localization and delineation. Thanks to advances in bioimaging, brain cancer can be detected earlier and resected more reliably. Magnetic resonance imaging (MRI) is the most common and preferred method to delineate brain cancer, and a contrast agent is often required to enhance imaging contrast. Dendrimers, a special family of synthetic macromolecules, constitute a particularly appealing platform for constructing MRI contrast agents by virtue of their well-defined three-dimensional structure, tunable nanosize and abundant surface terminals, which allow the accommodation of high payloads and numerous functionalities. Tuning the dendrimer size, branching and surface composition in conjunction with conjugation of MRI functionalities and targeting moieties can alter the relaxivity for MRI, overcome the blood-brain barrier and enhance tumor-specific targeting, hence improving the imaging quality and safety profile for precise and accurate imaging of brain tumors. This short review highlights the recent progress, opportunities and challenges in developing dendrimer-based MRI contrast agents for brain tumor imaging.

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Section: Mri Contrast Agents Based On Dendrimer Nanotechnologymentioning

confidence: 99%

“…branching, generation and surface coating in conjunction with conjugation of contrast agents has led to different dendrimer-based MRI agents with altered relaxivities [36,37,40,41,67]. Gadomer®-17 ( Fig.…”

Section: Figurementioning

confidence: 99%

Dendrimer-based magnetic resonance imaging agents for brain cancer

et al. 2018

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“…The branching pattern of dendrimer molecules creates numerous functional groups that are readily available for chemical modification for numerous applications including binding of peptides, antibodies, specific ligands, and imaging agents. The branching pattern also provides ample interior space in the dendrimer molecule to carry therapeutic payloads [28,29]. Dendrimer-based contrast agents in medical imaging offer different advantages over conventional agents, including desirable blood pool properties with longer circulation and retention times and lymphatic retention [30].…”

Section: Liposomes and Micellementioning

confidence: 99%

Approaches in the Chemoprevention of Breast Cancer

Kelly¹

2013

J Cancer Sci Ther

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Nanotechnology in bioscience and therapeutics has advanced tremendously in this decade. Many nanoparticle formulations as well as passive and active targeted agents have been developed and proved effective preclinically in proof-of-concept models of different cancers.Many of these formulations use polymer nanoparticles, liposomes, bubkyballs, fullerenes, carbon nanotubes, dendrimers, isotope tags, and PEG compounds. In effect, nanoparticle formulations have become the norm in chemoprevention. In this paper we review nanoformulations of bioactive compounds that have been tested for their potential mechanistic antiproliferative activity in breast cancer. We also discuss the possibility of enhancing the activity of these compounds using different innovative bioconjugation methods. Citation: Dileep KV, Kelly M, Hardin E, Sadasivan C, Nair HB (2013) Approaches in the Chemoprevention of Breast Cancer. J Cancer Sci Ther 5: 282-288. doi:10.4172/1948-5956.1000217 Volume 5 number of bound reporter metal atoms per vesicle and decrease dosage without compromising signal intensity. Adding specific targeted moieties to the liposomes also could improve the targeting of contrast agents designed for breast cancer imaging. Another research group has recently reported monoclonal antibody to 2C5 (mAb2C5) that can specifically detect tumor cells, leaving the normal cells behind [9]. It is claimed that these liposomes are capable of specifically delivering diagnostic moieties to various tumors with short image acquisition time. Another group has showed PEGylated immunoliposomes labeled with 99 Tc, surface conjugated with F fragment of GAH mAb, could target human gastric cancer in a murine model [10]. Some other studies investigating immunotargeted liposomes for MR imaging enhanced their contrast using gadopentetate dimeglumine (Gd-complex) [11]. MRI signal amplification is also achieved by combining PAP and Gd moietiesin mAb2C5-modified antibodies [12]. Superior in vivo tumor accumulation of mAb2C5 in mouse models of murine Lewis lung carcinoma has been achieved by modified PAP-containing pegylated liposomes, enabling faster detection of the solid tumors [13]. Use of primary and secondary antibodies for increasing the contrast has also been tested. Typically in this inverse imaging technique, patients will receive first antitumor antibody systemically for tumor imaging. This is followed by a second antibody, encapsulated in liposomes directed against the first antibody, which enhances reticuloendothelial (RES) clearance of the first antibody, enabling distinction between normal and tumor tissues [14]. This technology has stability issues with its secondary antibody and needs to be further refined for clinical diagnostic use. Approaches in the Chemoprevention of Breast Cancer Journal ofQuantum dots: Quantum dots (QD) became powerful tools to improve molecular imaging and diagnostics as a result of their unique photophysical properties [15][16][17]. The unique features of QD are resistance to photo bleaching high signal ...

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“…Since dendrimers have unique chemical structures, molecular weight and molecular size which can provide special type of functionality, they receive privileged attention in developing fields of materials science [15]- [18]. Considering large number of terminal groups on the exterior of the molecule and interior voids, dendrimers introduce as an attractive platform for metal ion celates [19]. Indeed, dendrimer-entraped inorganic nanoparticles (DENP) include a nanostructure where one or more inorganic nanoparticles with the diameter of less than 5 nm are entrapped within an individual dendrimer molecule.…”

Section: Introductionmentioning

confidence: 99%

Imaging and Therapeutic Applications of Optical and Thermal Response of SPION-Based Third Generation Plasmonic Nanodendrimers

Tajabadi¹,

Khosroshahi²,

Bonakdar³

2015

OPJ

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In this study, 9 nm superparamagnetic iron oxide nanoparticles (SPION) were functionalized by polyamidoamine (PAMAM) dendrimer. Using tetracholoroauric acid (HAuCl 4 ), magnetodendrimer (MD) samples were conjugated by gold nanoparticles (Au-NPs). Two different reducing agents, i.e. sodium borohydride and hydrazine sulfate, and pre-synthesized 10-nm Au-NP were used to evaluate the efficiency of conjugation method. The samples were characterized using X-ray diffractometry (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, UV-visible spectroscopy and fluorescence spectroscopy. The results confirmed that AuNPs produced by sodium borohydrate and the pre-synthesized 10-nm Au-NPs were capped by MDs whereas the Au-NP prepared by hydrazine sulfate as a reducing agent was entrapped by MDs. Optical properties of the MDs were studied by laser-induced fluorescence spectroscopy (LIF) within a wide range of visible spectrum. Also, based on the thermal analysis, all synthesized nanostructures exhibited a temperature increase using 488 nm and 514 nm wavelengths of a tunable argon laser. The new iron oxide-dendrimer-Au NPs synthesized by sodium borohydrate (IDANaBH4) produced the highest temperature increase at 488 nm whereas the other nanostructures particularly pure Au-NPs produced more heating effect at 514 nm. These findings suggest the potential application of these nanocomposites in the field of bioimaging, targeted drug delivery and controlled hyperthermia. M. Tajabadi et al.213

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PAMAM Dendrimer Based Macromolecules as Improved Contrast Agents

Cited by 151 publications

References 56 publications

Dendrimer-based magnetic resonance imaging agents for brain cancer

Dendrimer-based magnetic resonance imaging agents for brain cancer

Approaches in the Chemoprevention of Breast Cancer

Imaging and Therapeutic Applications of Optical and Thermal Response of SPION-Based Third Generation Plasmonic Nanodendrimers

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