Panax ginseng and Eleuthrococcus senticosus extracts - in vitro studies on binding to steroid receptors.

Pearce, P.; Zois, I; Wynne, K.N.; Funder, J. W.

doi:10.1507/endocrj1954.29.567

Cited by 33 publications

(17 citation statements)

References 11 publications

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“…This phenomenon has been described previously with saponin hemolytic activity (Pearce et al, 1982). In this way, ginsenosides may exert a synergistic effect with other plant constituents, which in turn influences their physiological effects.…”

Section: Discussionsupporting

confidence: 65%

Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: Differential effects on postprandial glycemia in healthy individuals

Souza

Jenkins

Sievenpiper

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 65%

Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: Differential effects on postprandial glycemia in healthy individuals

Souza

Jenkins

Sievenpiper

et al. 2011

Journal of Ethnopharmacology

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“…There is evidence that E 2 interferes with P 4 action in human spermatozoa, including an inhibition of P 4 -stimulated calcium flux [66], [67]. Pearce et al [105] showed that ginseng extract bound the P 4 receptor in rat uterine tissue. By contrast, α-zearalenol proved to be a powerful chromatin decondensation agent with P 4 , perhaps compromising the disulfide bonds required for chromatin condensation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Panax ginseng, zearalenol, and estradiol on sperm function

Gray

Lackey

Boone

2016

Journal of Ginseng Research

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BackgroundEstrogen signaling pathways are modulated by exogenous factors. Panax ginseng exerts multiple activities in biological systems and is classified as an adaptogen. Zearalenol is a potent mycoestrogen that may be present in herbs and crops arising from contamination or endophytic association. The goal of this study was to investigate the impact of P. ginseng, zearalenol and estradiol in tests on spermatozoal function.MethodsThe affinity of these compounds for estrogen receptor (ER)—alpha and beta (ERα and ERβ)—was assessed in receptor binding assays. Functional tests on boar spermatozoa motility, movement and kinematic parameters were conducted using a computer-assisted sperm analyzer. Tests for capacitation, acrosome reaction (AR), and chromatin decondensation in spermatozoa were performed using microscopic analysis.ResultsZearalenol—but not estradiol (E2)- or ginseng-treated spermatozoa—decreased the percentage of overall, progressive, and rapid motile cells. Zearalenol also decreased spontaneous AR and increased chromatin decondensation. Ginseng decreased chromatin decondensation in response to calcium ionophore and decreased AR in response to progesterone (P4) and ionophore.ConclusionZearalenol has adverse effects on sperm motility and function by targeting multiple signaling cascades, including P4, E2, and calcium pathways. Ginseng protects against chromatin damage and thus may be beneficial to reproductive fitness.

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“…It seems to have corticosteroid-like actions and hypoglycemic activity and also affects neurotransmitter activity (58). A ginsenoside extract from P. ginseng demonstrated affinity for progestin, mineralocorticoid, and glucocorticoid receptors in vitro (82). In rats, ginseng saponins increase adrenocorticotropic hormone and corticosterone secretion (83).…”

Section: Ginseng (Panax Ginseng and Others)mentioning

confidence: 99%

Diagnostic and Statistical Manual of Mental Disorders

Luyten¹

2018

The SAGE Encyclopedia of Educational Research, Measurement, And Evaluation

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Alternative therapies are widely used by consumers. A number of herbs and dietary supplements have demonstrable effects on mood, memory, and insomnia. There is a significant amount of evidence supporting the use of Hypericum perforatum (St. John's wort) for depression and Ginkgo biloba for dementia. Results of randomized, controlled trials also support the use of kava for anxiety and valerian for insomnia. Although evidence for the use of vitamins and amino acids as sole agents for psychiatric symptoms is not strong, there is intriguing preliminary evidence for the use of folate, tryptophan, and phenylalanine as adjuncts to enhance the effectiveness of conventional antidepressants. S-adenosylmethionine seems to have antidepressant effects, and omega-3 polyunsaturated fatty acids, particularly docosahexaenoic acid, may have mood-stabilizing effects. More research should be conducted on these and other natural products for the prevention and treatment of various psychiatric disorders.

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Panax ginseng and Eleuthrococcus senticosus extracts - in vitro studies on binding to steroid receptors.

Cited by 33 publications

References 11 publications

Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: Differential effects on postprandial glycemia in healthy individuals

Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: Differential effects on postprandial glycemia in healthy individuals

Effects of Panax ginseng, zearalenol, and estradiol on sperm function

Diagnostic and Statistical Manual of Mental Disorders

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