Pancreatic cancer: Incidence, clinical profile, and frequency of associated factors in Kuwait

Al-Majed, Hana T; Elbasmi, A; Al-Mohannadi, S.; Govindan, Rogini; Rajakumari, Glory B.

doi:10.1016/j.ajme.2012.06.004

Cited by 7 publications

(7 citation statements)

References 37 publications

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“…The mean age of our patients was 61.24 years, which is similar to that observed in other studies. [22][23][24][25][26][27][28] However, other literature data reported higher average age (67-77 years). [29][30][31][32] In accordance with the results of other studies, the patients were predominantly males.…”

Section: Discussionmentioning

confidence: 78%

“…27,36,37 Present study showed that the tumor was located to the pancreatic head in the majority of cases (71.6%), This was in accordance with the results reported in the literature. 22,25,28 As for many other cancers in Morocco, we noted that the majority of our patients presented with locally advanced or metastatic disease. This confirms the late presentation of PDAC and agrees with the finding of other studies.…”

Section: Discussionmentioning

confidence: 93%

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Pancreatic ductal adenocarcinoma in a Moroccan population: analysis of six years experience

et al. 2018

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Background: Few studies have been done to investigate pancreatic cancer in Morocco. Therefore, the aim of our study was to describe the epidemiological, clinical and therapeutic features of pancreatic ductal adenocarcinoma in Moroccan population.Methods: Author retrospectively reviewed the medical data of pancreatic ductal adenocarcinoma patients presented to the Medical Oncology Department of the Military Hospital Moulay Ismail in Meknes, Morocco, from January 2011 to December 2016.Results: The study included 67 cases of pancreatic ductal adenocarcinoma. The mean age of patients was 61.24±10.35 years. Male/female ratio was 3.2/1. 20.9% of patients were cigarette smokers, 10.5% alcoholics. 23.9% diabetics, 3.0% with a positive family history of pancreatic cancer and 25.4% with a family history of diabetes mellitus. The main symptoms for consultation were weight loss (68.6%), abdominal pain (64.2%), jaundice (53.7%) and vomiting (25.4%). The tumour was located to the pancreatic head in 71.6% of cases. Stage IV disease was the most common stage representing 47.8% of patients. Biliary and duodenal stent placements were respectively performed in 10.4% and 3.0% of patients. 23.9% of patients underwent curative surgery, 7.5% had palliative surgery and 86.6% received chemotherapy. The median overall survival for the entire cohort was 9.3 months (95% CI 7.2-12.1 months) with a median follow-up of 9.7 months (2-63 months).Conclusions: The data on pancreatic ductal adenocarcinoma in Moroccan population are similar to the epidemiologic literature data. With multimodality treatments, the results in terms of survival benefit seem to be similar to those in Asian and Caucasian populations.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 93%

Pancreatic ductal adenocarcinoma in a Moroccan population: analysis of six years experience

et al. 2018

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“…The risk of pancreatic cancer increases with age, with 80% of cases diagnosed at age 60-80. 32 Only about 10% of patients have pancreatic cancer under 50 years old, and pancreatic cancer is a rare condition at the age of under 25. 32 In the United States, 81.4% of patients are diagnosed with pancreatic cancer over 60 years old.…”

Section: Discussionmentioning

confidence: 99%

“… 32 Only about 10% of patients have pancreatic cancer under 50 years old, and pancreatic cancer is a rare condition at the age of under 25. 32 In the United States, 81.4% of patients are diagnosed with pancreatic cancer over 60 years old. In the past 6 decades, only 1 in every 100,000 Americans aged 20-29 had pancreatic cancer; however, at the age of over 80, this figure reached 87.2 in every 100,000 people.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of Pancreatic Cancer in Vietnam: A Matched Case–Control Hospital-Based Study

et al. 2021

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Background: Data about the risk factors and pancreatic cancer in developing countries remain limited. We investigated for the first time the role of a number of risk factors (family cancer history, smoking, alcohol consumption, diabetes, inflammation disease, HBV infection) associated with pancreatic cancer among Vietnamese patients. Methods: We included all patients hospitalized at 4 Northern Vietnamese hospitals (Vietnam National Cancer Hospital, Bach Mai, Viet Duc, Thai Nguyen) and diagnosed with pancreatic cancer during the period from 2017 to 2019. Risk factors of eligible patients were collected and assessed the associations using a matched control study and logistic regression model analysis. Results: We identified 196 patients with diagnosis of pancreatic cancer of which 114 males and 82 females. The average age of the patient at the time of diagnosis was 58.28 years (standard deviation of 12.94, ranging from 25 to 87). Most of patients were diagnosed at advanced stage (85%). Smoking, diabetes, inflammation disease significantly increased the cancer risks (OR and 95% CI were 2.42 (1.38-4.37), 3.09 (1.54-6.68), 2.21 (1.42-3.45), respectively). HBV infection demonstrated a significant link with pancreatic cancer in univariate model (OR = 2.94 (1.08-9.36)), but not in multivariate model. However, cancer family history and alcohol drinkers did not show any significantly increased risk related to pancreatic cancer. Conclusions: Our finding showed smoking, diabetes, inflammation disease significantly increased the risk of pancreatic cancer in Vietnam.

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“…Pancreatic cancer is an uncommon tumor, but because the mortality rate approaches 100%, this form of cancer has now become a common cause of cancer mortality [1]. The poor prognosis of pancreatic cancer has been attributed to its late diagnosis, aggressive local invasion, and early metastases [2].…”

Section: Introductionmentioning

confidence: 99%

Finding a Potential Bruceine D Inhibitor for Apoptotic Resistance Protein Pancreatic Cancer Based on Molecular Docking

Wulanawati

Noviardi²,

Ibrohim

2018

Indones. J. Chem.

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Pancreatic cancer: Incidence, clinical profile, and frequency of associated factors in Kuwait

Cited by 7 publications

References 37 publications

Pancreatic ductal adenocarcinoma in a Moroccan population: analysis of six years experience

Pancreatic ductal adenocarcinoma in a Moroccan population: analysis of six years experience

Risk factors of Pancreatic Cancer in Vietnam: A Matched Case–Control Hospital-Based Study

Finding a Potential Bruceine D Inhibitor for Apoptotic Resistance Protein Pancreatic Cancer Based on Molecular Docking

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