Pancreatic Carcinoma With Dissemination to Umbilicus and Skin

Umbilical metastasis or Sister Mary Joseph's nodule

“…13,20,29,32,53 Most cases involved metastasis of adenocarcinoma (278/ 368). [7][8][9][10][11][12][13]15,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][32][33][34][35][36][37]41,42,[44][45][46][47][48][49][53][54][55][56][57][58][59][60][61][62][63][64] Fifteen cases of s...…”

“…In 152 cases (152/368), umbilical metastasis was discovered before the diagnosis of primary cancer; 7,8,35,39,41,42,44,46,47,[50][51][52][53][54][55][56][58][59][60][61][62][63] Sister Mary Joseph's nodule was the only initial presentation of internal malignancy in 97 of these 152 cases. 7,[11][12][13][14][15][16]18,19,[21][22][23][24][25][26][27][28][29][30][31][32][33]35,41,44,46,47,50,51,…”

“…,10,12,13,19,23,25,33,44,45,58,[60][61][62][63] They occurred mainly in men (22/37 cases),7,10,12,13,23,44,58,[60][61][62][63] with 14 women10,12,19,23,33,44,45 and one undetermined case 25. The histologic pattern was usually adenocarcinoma, except for one case of undifferentiated carcinoma 19.…”