Pancreatic endocrine tumor coexistent with serous microcystic adenoma: report of a case and review of the literature

Alasio, Teresa M.; Vine, Anthony; Sanchez, Miguel A.; Dardik, Herbert

doi:10.1016/j.anndiagpath.2005.03.006

Cited by 16 publications

(11 citation statements)

References 9 publications

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“…1 Synchronous primary pancreatic tumors are rare and reports of various combinations of benign and malignant tumors of the exocrine or endocrine pancreas have been published. [2][3][4][5] Autopsy studies have reported an association between neoplastic cystic lesions or pancreatic adenocarcinoma and endocrine tumors of the pancreas. 4,6 Due to the relatively small number of cases, however, pathogenic pathways have not been yet elucidated and in most cases the coexistence of multiple pancreatic tumors is thought to represent a distinct and possibly unrelated tumor growth.…”

Section: Introductionmentioning

confidence: 99%

Synchronous primary epithelial tumors of the pancreas

Karidis

Paraskeva

Mantas

2012

International Journal of Surgery Case Reports

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Section: Introductionmentioning

confidence: 99%

Synchronous primary epithelial tumors of the pancreas

Karidis

Paraskeva

Mantas

2012

International Journal of Surgery Case Reports

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“…SCNs associated with other neoplasms as collision tumors are very unusual. On this topic, the most frequent combination is SCNs with pancreatic endocrine neoplasms [2]. Occasionally, SCNs are associated with ductal or intraductal papillary-mucionus tumors of the pancreas, but in these cases both tumors are localized in different areas.…”

Section: Sirmentioning

confidence: 99%

“…The most important and largest group is that of the epithelial neoplasms, which includes the most common cystic neoplasms: serous cystic neoplasms (SCNs), mucinous cystic neoplasms (MCNs), intraductal papillary-mucinous neoplasms, and solid pseudopapillary neoplasms, but also ductal adenocarcinomas and endocrine tumors with cystic features [6]. In general, SCNs are benign tumors that usually neither relapse nor metastasize and are composed of clear, glycogen-rich cells [2,6,7]. Nevertheless, MCNs are a more complex histological group comprising benign and borderline neoplasms and in situ and invasive carcinoma.…”

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A malignant mucinous cystic neoplasm arising within a mycrocystic adenoma of the pancreas

2006

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Sir:Cystic tumors of the pancreas are a heterogeneous group of neoplasms that includes epithelial tumors (benign, borderline, and malignant) and mesenchymal tumors (benign and malignant). These cystic neoplasms should be differentiated from cystic nontumoral lesions such as pancreatitis-associated pseudocysts, lymphoepithelial cysts, and other cystic lesions [6]. The most important and largest group is that of the epithelial neoplasms, which includes the most common cystic neoplasms: serous cystic neoplasms (SCNs), mucinous cystic neoplasms (MCNs), intraductal papillary-mucinous neoplasms, and solid pseudopapillary neoplasms, but also ductal adenocarcinomas and endocrine tumors with cystic features [6]. In general, SCNs are benign tumors that usually neither relapse nor metastasize and are composed of clear, glycogen-rich cells [2,6,7]. Nevertheless, MCNs are a more complex histological group comprising benign and borderline neoplasms and in situ and invasive carcinoma. In some cases of MCN, several patterns of growing or grades of malignancy may be simultaneously found, but irrespective of the histologic appearance of the epithelial component, with or without stromal invasion, pancreatic MCNs should all be considered as mucinous cystadenoma of lowgrade malignant potential [6,9].Combined cystic pancreatic neoplasms of serous-mucinous type are very infrequent, with few cases described in the English literature [1,8]. In this article we report one case of SCN, type serous microcystic adenoma (SMA), combined and intermingled with a MCN, that showed several growth patterns, and foci of invasive adenocarcinoma. We present the case of an 81-year-old woman who came to our hospital because of epigastralgia and dysphagia for the past 3 months. At the serum studies, a light increased level of cancer antigen (CEA) was present (20.2 ngr/mL) and the scanner showed a mass localized in the tail of the pancreas, with radiological features of MA. The ultrasonography and the scanner did not show diffuse or segmental cystic ectasia of the main and secondary pancreatic ducts.In July 2005, a resection of the body and tail of the pancreas was performed. The patient died 3 months thereafter due to a severe peripancreatic hemorrhage. During this time, she had been operated on again and local relapse and metastases were not found. An autopsy was not performed.The specimen of pancreatectomy showed a welldelimited mass measuring 9×7×5 cm in size with numerous tiny cysts ranging from 0.1 to 1 cm in diameter. The cysts were filled of serous fluid and surrounded by thin fibrous septa. At the periphery there was a localized, wedge-shaped stromal thickening of cicatricial appearance. The tumor was not related to the main pancreatic duct (Fig. 1). Microscopically, 70% of the tumor corresponded to a typical SMA with cysts of different sizes lined by a single layer of cuboidal or flattened epithelial cells with clear cytoplasms and central, round to oval nuclei with inconspicuous nucleoli. The stroma in between was acellular and collagenous with f...

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“…To date, six cases have been reported in the literature. [1][2][3][4][5][6] Another case of pancreatic cystadenoma associated with a neuroendocrine tumour was reported by Persaud and Walrond in 1971, 7 but the pathological findings described in that paper suggest that the cystadenoma was mucinous in type.…”

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confidence: 99%

“…The first case was published in 1993 by Heresbach et al, 1 and was a pancreatic serous cystadenoma associated with a cystadenocarcinoma and a nonfunctioning endocrine tumour in a 70-year-old patient. From 1996 2 to 2005, 6 four other cases of serous cystadenoma associated with endocrine tumour were reported.…”

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Three cases of pancreatic serous cystadenoma and endocrine tumour

et al. 2006

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Aims: To report three cases of serous cystadenoma and endocrine tumour in the same pancreas, to review the literature and to evaluate the clinicopathological features of the tumours. Cases: Three women (71, 57 and 31 years old) were admitted to hospital, two for diseases unrelated to the pancreas and the third for increasing obstructive jaundice in von Hippel-Lindau disease. Preoperative examination showed two distinct lesions in the first patient and only cystic lesions in the other two. Results: Histological examination of the pancreas showed one serous oligocystic adenoma associated with a benign, well-differentiated endocrine tumour, one serous oligocystic adenoma associated with an endocrine microadenoma, and a von Hippel-Lindau-related cystic neoplasm with a well-differentiated endocrine carcinoma. Conclusions: Serous cystadenoma associated with endocrine tumour shows some clinicopathological differences with respect to the two tumours considered separately, and with respect to von Hippel-Lindaurelated cases, although there is no convincing evidence at present to justify considering this association as a separate entity.

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Pancreatic endocrine tumor coexistent with serous microcystic adenoma: report of a case and review of the literature

Cited by 16 publications

References 9 publications

Synchronous primary epithelial tumors of the pancreas

Synchronous primary epithelial tumors of the pancreas

A malignant mucinous cystic neoplasm arising within a mycrocystic adenoma of the pancreas

Three cases of pancreatic serous cystadenoma and endocrine tumour

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