Pancreatoblastoma managed by pancreatoduodenectomy and extended right lobectomy

Hamada, Y.; Sato, Masahito; Okamura, Shigeo; Sanada, Toshiaki; Tsuji, Masazumi; Kogata, Munehisa; Hioki, Koshiro

doi:10.1007/bf00182235

Cited by 2 publications

(4 citation statements)

References 7 publications

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“…As there are no reports of long-term survival in any patient who did not undergo resection, complete tumour removal is recommended [30,33,80,89] and is strongly supported by the results of the survival analyses undertaken in the present study. Complete resection was achieved in approximately two-thirds of the patients as reported in literature [77] and in 80% in the present study.…”

Section: Treatmentsupporting

confidence: 62%

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Diagnosis, treatment and outcome of pancreatoblastoma

et al. 2004

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Section: Treatmentsupporting

confidence: 62%

“…Obstructive jaundice as a presentation was reported in 12 (11%) patients [10,27,33,42,45,63,72,76,80,86,87] and diarrhoea in 16 (14%) [8,9,17,19,27,29,44,55,57,63,72,88,90] out of 112 patients. There were 17 (17%) [10,14,24,37,38,43,44,49,55,62,65,66,80,82] out of 101 patients who presented with metastatic disease.…”

Section: Mode Of Presentationmentioning

confidence: 99%

Diagnosis, treatment and outcome of pancreatoblastoma

et al. 2004

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“…Patients with metastatic disease have a less favorable prognosis, but they profit from chemotherapy and radiotherapy. Cisplatin, doxorubicin, etoposide, cyclophosphamide, vincristine, and adriamycin have proved to be effective chemotherapeutic agents [3,12,13,15]. A possible treatment regimen differentiating encapsulated and infiltrating tumors is presented in Figure 1.…”

Section: Pancreatoblastomamentioning

confidence: 99%

“…Tumor markers have been investigated in only a few cases in the literature, with AFP elevation in 50% of the patients [1,12,13]. Although AFP seems to be a suitable marker in some children, it might become normal during follow-up of still metastasizing tumors [14].…”

Section: Pancreatoblastomamentioning

confidence: 99%

Therapeutic Management of Rare Malignant Pancreatic Tumors in Children

1998

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Malignant pancreatic tumors in children are rare. The major problem for the clinician is a lack of experience and of accepted therapeutic strategies. Malignant pancreatic tumors in children show a pattern different from that in adults. In infants, especially pancreatoblastomas, solid cystic tumors of females, and endocrine carcinomas of the pancreas must be expected. We report our experience in three patients with malignant pancreatic tumors (one pancreatoblastoma and two malignant endocrine pancreatic carcinomas) and review the present literature with a focus on the typical clinical and biologic features and the presently recommended therapeutic strategies. Pancreatoblastomas and solid cystic tumors are mainly found in the head of the pancreas. Fibrotic capsules with rare, late metastases are characteristics of these tumors, indicating total resection to be an important therapeutic procedure. Pancreatoblastomas should additionally be treated with chemotherapy (ADM, IFO, cis-PL, VP16). Endocrine carcinomas of the pancreas (malignant gastrinomas and malignant insulinomas) should also primarily be treated with radical surgery, including extensive lymph node dissection. In case of distant metastases, local resection (liver) or somatostatin in combination with chemotherapy (streptozocin in the case of malignant insulinomas) may be used.

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Pancreatoblastoma managed by pancreatoduodenectomy and extended right lobectomy

Cited by 2 publications

References 7 publications

Diagnosis, treatment and outcome of pancreatoblastoma

Diagnosis, treatment and outcome of pancreatoblastoma

Therapeutic Management of Rare Malignant Pancreatic Tumors in Children

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