Panosialins, Inhibitors of Enoyl-ACP Reductase from Streptomyces sp. AN1761

Kwon, Yun Ju; Sohn, Mi Jin; Oh, Tae-Ho; Cho, Sang Nae; Kim, Chang‐Jin; Kim, Won Gon

doi:10.4014/jmb.1209.09038

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…In 2013, the same team isolated four acyl-benzenediol sulphate metabolites, panosialins A , B , wA and wB ( Figure 41 ), from Streptomyces sp. AN1761 [ 170 ]. These four molecules were active against Sa FabI and Sp FabK with IC 50 values in the range of 1.3–5.5 µM.…”

Section: Fas-ii Enzymes and Their Corresponding Inhibitorsmentioning

confidence: 99%

A Review of Fatty Acid Biosynthesis Enzyme Inhibitors as Promising Antimicrobial Drugs

et al. 2023

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Resistance to antimicrobial drugs is currently a serious threat to human health. Consequently, we are facing an urgent need for new antimicrobial drugs acting with original modes of action. The ubiquitous and widely conserved microbial fatty acid biosynthesis pathway, called FAS‑II system, represents a potential target to tackle antimicrobial resistance. This pathway has been extensively studied, and eleven proteins have been described. FabI (or InhA, its homologue in mycobacteria) was considered as a prime target by many teams and is currently the only enzyme with commercial inhibitor drugs: triclosan and isoniazid. Furthermore, afabicin and CG400549, two promising compounds which also target FabI, are in clinical assays to treat Staphylococcus aureus. However, most of the other enzymes are still underexploited targets. This review, after presenting the FAS-II system and its enzymes in Escherichia coli, highlights the reported inhibitors of the system. Their biological activities, main interactions formed with their targets and structure–activity relationships are presented as far as possible.

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Section: Fas-ii Enzymes and Their Corresponding Inhibitorsmentioning

confidence: 99%

A Review of Fatty Acid Biosynthesis Enzyme Inhibitors as Promising Antimicrobial Drugs

et al. 2023

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“…Research on algal lipids found that loliolide, a ubiquitous monoterpenoid lactone isolated from C. tomentosum, may be used as a neuroprotective agent (Silva et al 2021). The properties of oleamide, an amide derived from the fatty acid oleic acid of Codium, have been reviewed (Kwon et al 2001;Moon et al 2018b). Chemical structure of lipid derivated compounds from Codium species is shown in Fig.…”

Section: Bioactivitiesmentioning

confidence: 99%

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

2022

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The genus Codium is one of the most important genera of marine green macroalgae. Its distribution is widespread worldwide and it has a high degree of diversity in species and characteristics. This genus plays an important ecological role in marine ecosystems as it is a primary producer. However, some species in the genus Codium are invasive species and may disturb the functioning of the ecosystem. Economically, Codium has promising potential as a source of diverse nutritional and pharmacological compounds. Codium is edible, has a high nutrient value, and is rich in bioactive compounds. Hence, some species of Codium have been consumed as food and used as herbal medicines in some Asian countries. In recent decades, studies of the bioactivity and pharmacological properties of the genus Codium have attracted the attention of scientists. This review aims to identify gaps in studies analyzing Codium that have been conducted in the past three decades by assessing published research articles on its bioactivity and pharmacological properties. Compounds obtained from Codium have demonstrated significant biological activities, such as immunostimulatory, anticoagulant, anticancer, anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal, antitumor, anti-angiogenic, osteoprotective, and anti-obesity activities. This review provides information that can be used as a future guideline for sustainably utilizing the genus Codium.

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Recent Advances in Inhibitors of Bacterial Fatty Acid Synthesis Type II (FASII) System Enzymes as Potential Antibacterial Agents

Wang

2013

ChemMedChem

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Bacterial infections are a constant and serious threat to human health. With the increase of multidrug resistance of clinically pathogenic bacteria, common antibiotic therapies have been less effective. Fatty acid synthesis type II (FASII) system enzymes are essential for bacterial membrane lipid biosynthesis and represent increasingly promising targets for the discovery of antibacterial agents with new mechanisms of action. This review highlights recent advances in inhibitors of bacterial FASII as potential antibacterial agents, paying special attention to the activities, mechanisms, and structure-activity relationships of those inhibitors that mainly target β-ketoacyl-ACP synthase, β-ketoacyl-ACP reductase, β-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase. Although inhibitors with low nanomolar and selective activity against various bacterial FASII have entered clinical trials, further research is needed to expand upon both available and yet unknown scaffolds to identify new FASII inhibitors that may have antibacterial potential, particularly against resistant bacterial strains.

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Panosialins, Inhibitors of Enoyl-ACP Reductase from Streptomyces sp. AN1761

Cited by 5 publications

References 12 publications

A Review of Fatty Acid Biosynthesis Enzyme Inhibitors as Promising Antimicrobial Drugs

A Review of Fatty Acid Biosynthesis Enzyme Inhibitors as Promising Antimicrobial Drugs

A concise review of the bioactivity and pharmacological properties of the genus Codium (Bryopsidales, Chlorophyta)

Recent Advances in Inhibitors of Bacterial Fatty Acid Synthesis Type II (FASII) System Enzymes as Potential Antibacterial Agents

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