Paper-Based Microfluidic Devices: Emerging Themes and Applications

Yang, Yuanyuan; Noviana, Eka; Nguyen, Michael P.; Geiss, Brian J.; Dandy, David S.; Henry, Charles S.

doi:10.1021/acs.analchem.6b04581

Cited by 454 publications

(291 citation statements)

References 211 publications

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“…Our device opens up for sample preparation applications in paper fluidics based diagnostics. 39,40 The limitations and challenges introduced by working with open devices on the other hand include the risk for evaporation, contamination and biohazard. 41 These issues can be mitigated through a cover that is positioned in close proximity, yet not in contact with the actual device.…”

Section: Resultsmentioning

confidence: 99%

Open channel deterministic lateral displacement for particle and cell sorting

Tran

Beech

et al. 2017

Lab Chip

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A simple, low-cost and robust approach was developed for sorting complex samples using open-architecture fluidics. The liquid flow was driven by a paper capillary pump that doubles as a reservoir for collection of the sorted fractions.Open channel deterministic lateral displacement for particle and rsc.li/locLab on a Chip We present the use of capillary driven flow over patterned surfaces to achieve cheap and simple, but powerful separation of biologically relevant particle systems. The wide use of microfluidics is often hampered by the propensity for devices to clog due to the small channel sizes and the inability to access the interior of devices for cleaning. Often the devices can only be used for a limited duration and most frequently only once. In addition the cost and power requirements of flow control equipment limits the wider spread of the devices. We address these issues by presenting a simple particle-and cell-sorting scheme based on controlled fluid flow on a patterned surface. The open architecture makes it highly robust and easy to use. If clogging occurs it is straightforward to rinse the device and reuse it. Instead of external mechanical pumps, paper is used as a capillary pump. The different fractions are deposited in the paper and can subsequently be handled independently by simply cutting the paper for downstream processing and analyses. The sorting, based on deterministic lateral displacement, performs equivalently well in comparison with standard covered devices. We demonstrate successful separation of cancer cells and parasites from blood with good viability and with relevance for diagnostics and sample preparation. Sorting a mixture of soil and blood, we show the potential for forensic applications.

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Section: Resultsmentioning

confidence: 99%

Open channel deterministic lateral displacement for particle and cell sorting

Tran

Beech

et al. 2017

Lab Chip

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“…Recently, microfluidic paper-based analytical devices (μPADs) have attracted a lot of attention and have been actively developed due to being simple, inexpensive, user-friendly, and disposable. [12][13][14][15][16] To date, μPADs have been used as elegant analytical tools for a variety of applications, including medical diagnosis, [17][18][19][20][21] food testing, 22 and environmental monitoring. [23][24][25][26][27][28][29] A lot of detection methods have been used for μPADs.…”

Section: Crmentioning

confidence: 99%

Microfluidic Paper-based Analytical Device for the Determination of Hexavalent Chromium by Photolithographic Fabrication Using a Photomask Printed with 3D Printer

Asano

Shiraishi

2018

ANAL. SCI.

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This article describes a simple and inexpensive microfluidic paper-based analytical device (μPAD) for the determination of hexavalent chromium (Cr VI ) in water samples. The μPADs were fabricated on paper by photolithography using a photomask printed with a 3D printer and functionalized with reagents for a colorimetric assay. In the μPAD, Cr VI reacts with 1,5-diphenylcarbazide to form a violet-colored complex. Images of μPADs were captured with a digital camera; then the red, green, and blue color intensity of each detection zone were measured using images processing software. The green intensity analysis was the best sensitive among the RGB color. A linear working range (40 -400 ppm; R 2 = 0.981) between the Cr VI and green intensity was obtained with a detection limit of 30 ppm. All of the recoveries were between 94 and 109% in recovery studies on water samples, and good results were obtained.

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“…1 For these reasons, μPADs are to be popular alternative devices to conventional ones for food safety analysis, 2,3 environmental monitoring, 4,5 and pointof-care diagnosis. [6][7][8][9] μPADs have been fabricated by a variety of methods, including (1) photolithography, [10][11][12] (2) wax printing, [12][13][14] (3) inkjet printing, [15][16][17][18] (4) screen printing, [19][20][21][22] and (5) craft cutting.…”

Section: Introductionmentioning

confidence: 99%