Papillary carcinoma of the thyroid in a 2-year old: Case report with review of the literature

Papillary thyroid carcinoma in a 3-year-old child: Case report

“…This is best illustrated by the report from Memorial 276 S. Alkan et al Sloan-Kettering Cancer Center, New York, where out of 327 patients less than 21 years with differentiated thyroid cancer 83 had distant metastasis; 90% of this group had regional nodal metastasis and 48% had extrathyroidal extension and all had distant metastasis to the lung at presentation. However, despite the aggressive clinical characteristic of differentiated thyroid carcinoma in their series survival rate was 100% after 10 years [10]. The bilateral neck dissection specimen of our patient showed numerous papillary carcinoma metastases, however studies on the lung were negative for disease.…”

“…Srikumar et al [10] reported that their 2 year 8 months old patient with thyroid papillary carcinoma was the second patient in British islands under age 3 diagnosed with thyroid papillary carcinoma. The patient presented here was also 3 years old (3 years and 2 months), and had a cervical mass that was present for 6 months, and was the youngest child in Turkey diagnosed with papillary thyroid carcinoma.…”

“…Differentiated thyroid carcinoma constitutes 0, 5-3% of all pediatric malignancies [1,4,9,10]. These cancers are exceedingly rare at ages younger than 5 years and increase in frequency through adolescence, with 70% of cases presenting between the ages of 11 and 17 years [2,3].…”

Thyroid Papillary Carcinoma in a 3-year-old American Boy with a Family History of Thyroid Cancer

“…[1][2][3][4] The most common type of DTC encountered in children is papillary thyroid carcinoma, most of which are believed to be related to radiation exposure 5,6 and only approximately 5% of cases have a family history of papillary thyroid carcinoma. 7 DTC is exceptionally rare in children younger than 5 years old.…”

“…When compared with adults, pediatric DTCs show a more aggressive clinical course with 60% to 80% presenting with regional lymph node metastasis and 10% to 20% with pulmonary metastasis. 1,2,4,[7][8][9] In this case report, we present a 3year-old American boy diagnosed with papillary thyroid carcinoma who has a family history of thyroid cancer and thyroid disease but no known history of radiation exposure, followed by a literature review with discussion on the management and treatment of pediatric thyroid papillary carcinoma.…”