Papillary thyroid carcinoma arising from ectopic thyroid tissue in a neck branchial cyst

Mremi, Alex; Nkya, Gilbert; Amsi, Patrick; Sadiq, Adnan; Lodhia, Jay; Pallangyo, Angela

doi:10.1177/2050313x231168555

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Lymphatic tissue is frequently visible in the histopathology of these lateral cysts [8], this presents a difficulty in distinguishing between cystic lymph nodes and branchial cysts. This cystic transformation and the subsequent development of carcinoma might elucidate the pathophysiology in our particular case, and similar cases have been reported [5,7].…”

Section: Discussionsupporting

confidence: 84%

“…To our current understanding, there have been only five documented instances of Papillary Thyroid Carcinoma (PTC) developing inside a branchial cyst without a thyroid primary [5][6][7][8]. There are some instances of PTC within lateral neck cysts, where either a primary thyroid tumor was later identified, or no thorough pathological examination of the thyroid was conducted.…”

Section: Discussionmentioning

confidence: 99%

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Papillary Thyroid Carcinoma Concealed Within a Branchial Cyst Without Primary Thyroid Involvement: Unveiling the Enigma

Khawaja,

Arshad,

Shafiq

et al. 2024

Cureus

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Branchial cleft cysts are congenital anomalies that form during fetal development and originate from the second branchial cleft. They typically manifest as painless masses on the side of the neck and can become symptomatic when infected. These cysts can create a cavity that may foster infection and, in rare instances, facilitate the spread of primary tumors. It is unusual to find ectopic thyroid tissue within a brachial cyst and it is even rarer to see papillary thyroid carcinoma developing from this tissue. Whenever physicians find a case of lateral neck cyst containing thyroid neoplasm without a known primary in the thyroid, there is always a confusion about whether it is a case of metastatic disease with an undetected primary tumor, or is a carcinoma originating from ectopic thyroid tissue. This is a case report of a papillary thyroid cancer that was unintentionally discovered inside a branchial cyst. So far, only five cases akin to this have been documented. There was no sign of an underlying primary thyroid tumor after the patient had a complete thyroidectomy and selected neck dissection, according to a comprehensive evaluation. This article touches on the development of thyroid tissue within branchial cysts and discusses the etiology of lateral neck tumors. The outcome for such patients appears to be favorable after cyst excision and total thyroidectomy. This article also emphasizes the importance of doing routine histopathological examinations on surgically removed samples that look benign.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Papillary Thyroid Carcinoma Concealed Within a Branchial Cyst Without Primary Thyroid Involvement: Unveiling the Enigma

Khawaja,

Arshad,

Shafiq

et al. 2024

Cureus

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Papillary carcinoma arising from de novo ectopic thyroid tissue within thyroglossal duct cyst: A rare case report

Pradhan,

Dutta,

Mondal

et al. 2024

JLP

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The most common congenital anomaly of thyroglossal duct is a thyroglossal duct cyst, but carcinoma arising from a thyroglossal duct cyst is a rare phenomenon. Carcinomas involving thyroglossal duct cysts are mostly papillary carcinomas. Definitive diagnosis of carcinomas involving thyroglossal duct cysts is done through surgical excision and subsequent histopathological examination. Most carcinomas arise de novo from ectopic thyroid tissue within thyroglossal duct cysts, but the direct spread of papillary carcinomas arising from the thyroid gland can also present themselves as carcinomas involving thyroglossal duct cysts in a minority of patients. Clinical presentation in most of the patients with carcinoma of thyroglossal duct cyst is quite similar to that of the patients with histopathologically diagnosed thyroglossal duct cyst, i.e., a painless anterior midline neck swelling with cosmetic concern and no other significant symptom(s). Careful clinical examination, imaging techniques, fine needle aspiration cytology, etc., can be helpful in indicating the presence of carcinoma preoperatively. Management of patients with thyroglossal duct cyst carcinoma involves only the Sistrunk procedure in the majority of cases. However, in a minority of patients, management by Sis trunk procedure with additional total thyroidectomy (with or without dissection of lymph nodes of the neck) and adjuvant chemo and radio-ablation therapies are needed. Here, we report a case of a 17-year-old female with papillary carcinoma involving thyroglossal duct cyst who presented with a submental swelling and was eventually managed by Sis trunk procedure, total thyroidectomy, and adjuvant therapies for optical cure. Decisions for the management of her cancer were taken through multidisciplinary interactions at tumor board meetings and by judging her surgical and therapeutic needs based on her clinical, radiological, and pathological findings.

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Papillary thyroid carcinoma arising from ectopic thyroid tissue in a neck branchial cyst

Cited by 2 publications

References 13 publications

Papillary Thyroid Carcinoma Concealed Within a Branchial Cyst Without Primary Thyroid Involvement: Unveiling the Enigma

Papillary Thyroid Carcinoma Concealed Within a Branchial Cyst Without Primary Thyroid Involvement: Unveiling the Enigma

Papillary carcinoma arising from de novo ectopic thyroid tissue within thyroglossal duct cyst: A rare case report

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