Paragangliomas of the Head and Neck: A Practical Approach to Diagnosis and Review of Detailed Anatomy of Sites of Origin

Noujaim, Samir; Brown, Karen T.; Walker, D.T.; Hasbrook, C.

doi:10.3174/ng.1900045

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…The gold standard treatment for CBTs has been surgical excision, with high rates of complete resection reported in the previous series [3,7,9,11,[24][25][26]. However, resection of these tumors carries inherent risks of injury to the carotid arteries and cranial nerves due to its anatomic location.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group

González-Urquijo

Viteri-Pérez²,

Becerril-Gaitan

et al. 2022

World j. surg.

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Background This study's objective was to conduct a multinational registry of patients with carotid body tumors (CBTs) and to analyze patients' clinical characteristics, treatments, and outcomes. Methods Retrospective study from the Carotid Paraganglioma Cooperative International Registry involving eleven medical centers in Bolivia, Ecuador, Mexico, and Spain, of all patients with a CBT who underwent resection between 2009 and 2019. Results A total of 1432 patients with a CBT surgically treated were included. Median patient age was 54 years (range: 45-63 years), and 82.9% (1184) of the study cohort were female. While at low altitude, the proportion of female-to-male cases was 2:1, at high altitude, this proportion increased to 8:1, with statistically significant differences (p = .022). Median operative time was 139 min (range: 110-180 min), while median operative blood loss was 250 ml (range: 100-500 ml), with statistically significant difference in increased blood loss (p = .001) and operative time (p = .001) with a higher Shamblin classification. Eight (0.6%) patients suffered stroke. Univariate analysis analyzing for possible factors associated with increased odds of stroke revealed intraoperative vascular lesion to present an OR of 2.37 [CI 95%;] (p = 0.001). In 245 (17.1%), a cranial nerve injury was reported. Seven (0.5%) deaths were recorded. ConclusionThe most common CBT type on this cohort was hyperplasic, which might be partially explained by the high altitudes where these patients lived. Increased blood loss and operative time were associated with a higher Shamblin classification, and the risk of stroke was associated with patients presenting transoperative vascular lesions.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group

González-Urquijo

Viteri-Pérez²,

Becerril-Gaitan

et al. 2022

World j. surg.

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“…Most patients with SP were diagnosed in middle age (40-59 years, 38.70%) or adolescence (10-19 years, 22.58%). SP is predominantly seen in males (65.63%), with a male-to-female ratio of 1.9:1, contrasting with the female-predominant carotid, vagal, tympanic, and laryngeal paragangliomas [ 34 , 35 ]. SP tumors are lobulated, firm, and highly vascular, with or without a capsule [ 1 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Gamma Knife Radiosurgery: An Adjuvant Therapy for Primary Sellar Paraganglioma

Bajagain,

Fujio,

Kirishima

et al. 2024

Cureus

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Sellar paraganglioma (SP) is a rare benign tumor, usually treated by surgery. SPs are lobulated, firm, adherent, and highly vascular, allowing mostly partial resection. We present the case of a 52-year-old man diagnosed with primary SP, treated with a transcranial-transsphenoidal (TC-TS) surgical approach, followed by adjuvant Gamma Knife stereotactic radiosurgery (GKSR). The tumor has an extra-pituitary origin, with a sellar-suprasellar, right cavernous sinus extension that encroached the bilateral optic nerve and anterior cerebral artery. Histopathology confirmed SP with a Zellballen pattern. Despite postoperative tumor growth observed at four and 10 months, a stable residual tumor was noted at a follow-up two years after GKSR. SP is diagnosed mainly in middle age or in adolescent males. The TC-TS approach offers a bidirectional view that allows greater resection by minimizing blind spots, thus reducing complications. Similar to the paragangliomas of other sites, the efficacy of GKSR was observed for primary SP. SP is a rare differential diagnosis of pituitary diseases; however, it should be considered. After surgical resection of primary SP, GKSR is observed as an effective adjuvant therapy.

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Imaging of Petrous Apex Lesions

Potter

Siripurapu

2021

Neuroimaging Clinics of North America

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Paragangliomas of the Head and Neck: A Practical Approach to Diagnosis and Review of Detailed Anatomy of Sites of Origin

Cited by 3 publications

References 33 publications

Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group

Clinical Characteristics and Surgical Outcomes of Carotid Body Tumors: Data from the Carotid Paraganglioma Cooperative International Registry (CAPACITY) Group

Gamma Knife Radiosurgery: An Adjuvant Therapy for Primary Sellar Paraganglioma

Imaging of Petrous Apex Lesions

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